Viral Shedding of COVID-19 in Pregnant Women

Wu, Yanting; Liu, Chen; Dong, Liang; Zhang, Chenjie; Yang, Chen; Li, Jun; Zhang, Chen; Duan, Cai-Wen; Zhang, Hanqiu; Mol, Ben Willem; Dennis, Cindy-Lee; Yin, Tailang; Yang, Jing; Huang, He‐Feng

doi:10.2139/ssrn.3562059

Cited by 20 publications

(27 citation statements)

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“…The single milk sample that was supposedly positive for SARS‐CoV‐2 (Wu et al, 2020) is clearly anomalous to the larger body of evidence. Importantly, since no methodologies were provided and the study has not been published in a refereed journal, any interpretation of this result must be made with extreme caution.…”

Section: Discussionmentioning

confidence: 99%

“…As such, it is possible that the presence of MERS‐CoV in camel milk could be due to contamination from the milker, the calf or the environment, rather than milk representing an endogenous source of the virus. This is likely an issue with all the studies on SARS‐CoV‐2, where only one reported cleaning of the breast prior to sample collection (Wu et al, 2020). However, the limited data available on all three of these viruses (and human coronaviruses, in general) leave many questions unanswered with respect to the role, if any, of human milk in vertical transmission of coronaviruses.…”

Section: Discussionmentioning

confidence: 99%

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SARS‐CoV‐2 and human milk: What is the evidence?

Lackey

Pace

Williams

et al. 2020

Maternal & Child Nutrition

127

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The novel coronavirus SARS‐CoV‐2 has emerged as one of the most compelling and concerning public health challenges of our time. To address the myriad issues generated by this pandemic, an interdisciplinary breadth of research, clinical and public health communities has rapidly engaged to collectively find answers and solutions. One area of active inquiry is understanding the mode(s) of SARS‐CoV‐2 transmission. Although respiratory droplets are a known mechanism of transmission, other mechanisms are likely. Of particular importance to global health is the possibility of vertical transmission from infected mothers to infants through breastfeeding or consumption of human milk. However, there is limited published literature related to vertical transmission of any human coronaviruses (including SARS‐CoV‐2) via human milk and/or breastfeeding. Results of the literature search reported here (finalized on 17 April 2020) revealed a single study providing some evidence of vertical transmission of human coronavirus 229E; a single study evaluating presence of SARS‐CoV in human milk (it was negative); and no published data on MERS‐CoV and human milk. We identified 13 studies reporting human milk tested for SARS‐CoV‐2; one study (a non‐peer‐reviewed preprint) detected the virus in one milk sample, and another study detected SARS‐CoV‐2 specific IgG in milk. Importantly, none of the studies on coronaviruses and human milk report validation of their collection and analytical methods for use in human milk. These reports are evaluated here, and their implications related to the possibility of vertical transmission of coronaviruses (in particular, SARS‐CoV‐2) during breastfeeding are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

SARS‐CoV‐2 and human milk: What is the evidence?

Lackey

Pace

Williams

et al. 2020

Maternal & Child Nutrition

127

View full text Add to dashboard Cite

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“…A study has observed negative viral test results in vaginal secretion specimens, suggesting that a vaginal delivery may be a safe delivery option. 24 In the same study, neonatal throat swabs were also negative. Taken together, these findings suggest that the risk of vertical transmission from pregnant women to newborn delivered by caesarean section is low.…”

Section: Management In a Pregnant Womanmentioning

confidence: 78%

“…40 Paradoxically, delaying chemotherapy or surgery worsens prognosis, but both modalities cause immunosuppression, thereby increasing the risk of COVID-19 infection. 33,24,41 Aerosol generating procedures during surgery such as intubation for general anaesthesia further increases the risk of transmission of the virus. 42,43 In patients with pre-invasive lesions or slow growing cancers, postponement of surgery may be considered.…”

Section: Impact Of Covid-19 On Gynaecologic Oncologymentioning

confidence: 99%

Obstetrics and gynaecology in the era of COVID-19

George

Manoj

Ramani

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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The World Health Organization has declared the outbreak of COVID-19 as a global pandemic. The alarming levels of spread and severity of the viral disease has resulted in significant morbidity and mortality. Women often face the highest risk of suffering devastating losses from the pandemic. Historically, women’s health has always been inadequately represented in responses to global outbreaks. Resources are often funnelled away from women’s health services towards targets perceived to be more important. Pregnant women with suspected, probable or confirmed COVID-19, should have access to obstetric and foetal medicine, neonatal care as well as mental health and psychosocial support, at facilities ready to tackle maternal and neonatal complications. In this article, we attempt to look at the challenges faced by gynaecologists because of this pandemic, and provide an overview on the current protocols in antenatal care, foetal care, childbirth, and oncological care.

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“…Indeed, the biological plausibility of perinatal infection has been underscored by the presence of the SARS-CoV-2 receptor, angiotensin-converting enzyme-2, in the placenta 50 and detection of the virus in amniotic fluid, placenta and breastmilk. 4,43,47,[51][52][53][54] After the early postnatal period, lateonset infections of SARS-CoV-2 have also been increasingly reported in infants, as a result of household and community transmission. 53,55,56 Therefore, management during delivery and the postnatal period have the potential to have a significant impact on the risk of infection for newborn infants born to mothers with COVID-19.…”

Section: Discussionmentioning

confidence: 99%