Viral Related Tools against SARS-CoV-2

Fernández-García, Laura; Pacios, Olga; González-Bardanca, Mónica; Blasco, Lucía; Bleriot, Inés; Ambroa, Antón; Lopez, Maria Claudia Negret; Bou, Germán; Tomás, María

doi:10.3390/v12101172

Cited by 3 publications

(4 citation statements)

References 136 publications

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“…COVID-19 began in China on December 19 and has since claimed many lives and is responsible for the largest global recession. is is due to the virus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1,2]. e spread of this virus can be reduced by using personal protective equipment and physical distance.…”

Section: Introductionmentioning

confidence: 99%

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The Study about Relationship of Direct Form of Topological Indices via M-Polynomial and Computational Analysis of Dexamethasone

Hussain

Afzal

et al. 2022

Journal of Chemistry

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Nowadays, all scientists are in the race to find a cure for COVID-19. This is a viral disease that is due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Different antiviral drugs are under investigation. Dexamethasone is being used for the treatment of COVID-19. In this article, the chemical structure of dexamethasone is explored using computational techniques such as topological indices. Proofs of a few closed formulas that describe the degree-dependent topological indices calculated from the M-polynomial of the graphs are also given in this article.

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Section: Introductionmentioning

confidence: 99%

“…By counting edges that have the same end-degrees in the chemical graph, then we can rewrite equation (1) as…”

Section: Introductionmentioning

confidence: 99%

The Study about Relationship of Direct Form of Topological Indices via M-Polynomial and Computational Analysis of Dexamethasone

Hussain

Afzal

et al. 2022

Journal of Chemistry

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“…Since 2012, MERS-CoV resulted in 2494 confirmed cases and 858 deaths with a mortality rate of 34.4%, higher than that of SARS-CoV (~10%) [15,16]. The latest outbreak of coronavirus emerged at the end of 2019 in Wuhan, China from a causative agent closely related to SARS-CoV, namely SARS-CoV-2, while the disease it causes was named COVID-19 (coronavirus disease) [17]. The COVID-19 outbreak spread internationally rapidly and was declared a pandemic by the WHO in March 2020 due to the alarming levels of spread, severity, and governments' inaction [18,19].…”

Section: Introductionmentioning

confidence: 99%

Discovery of Antivirals Using Phage Display

Sokullu

Gauthier

Coulombe

2021

Viruses

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The latest coronavirus disease outbreak, COVID-19, has brought attention to viral infections which have posed serious health threats to humankind throughout history. The rapid global spread of COVID-19 is attributed to the increased human mobility of today’s world, yet the threat of viral infections to global public health is expected to increase continuously in part due to increasing human–animal interface. Development of antiviral agents is crucial to combat both existing and novel viral infections. Recently, there is a growing interest in peptide/protein-based drug molecules. Antibodies are becoming especially predominant in the drug market. Indeed, in a remarkably short period, four antibody therapeutics were authorized for emergency use in COVID-19 treatment in the US, Russia, and India as of November 2020. Phage display has been one of the most widely used screening methods for peptide/antibody drug discovery. Several phage display-derived biologics are already in the market, and the expiration of intellectual property rights of phage-display antibody discovery platforms suggests an increment in antibody drugs in the near future. This review summarizes the most common phage display libraries used in antiviral discovery, highlights the approaches employed to enhance the antiviral potency of selected peptides/antibody fragments, and finally provides a discussion about the present status of the developed antivirals in clinic.

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“…In the review by Lundstrom (2020), the advantages of using viral particles and RNA replicons and DNA replicon vectors of RNA viruses for vaccine development are presented, with a special emphasis on COVID-19 viral-based vaccines [ 21 ]. The review by Fernandez-Garcia et al (2020) summarizes the recent research on viruses for therapy and diagnosis of COVID-19, namely viral-vector vaccines, bacteriophages to find SARS-CoV-2 antibodies, and their use as a treatment [ 22 ].…”

Section: Special Issue Overviewmentioning

confidence: 99%

An Overview of the Application of Viruses to Biotechnology

Varanda

Félix

Campos

et al. 2021

Viruses

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Viruses may cause devastating diseases in several organisms; however, they are simple systems that can be manipulated to be beneficial and useful for many purposes in different areas. In medicine, viruses have been used for a long time in vaccines and are now being used as vectors to carry materials for the treatment of diseases, such as cancer, being able to target specific cells. In agriculture, viruses are being studied to introduce desirable characteristics in plants or render resistance to biotic and abiotic stresses. Viruses have been exploited in nanotechnology for the deposition of specific metals and have been shown to be of great benefit to nanomaterial production. They can also be used for different applications in pharmacology, cosmetics, electronics, and other industries. Thus, viruses are no longer only seen as enemies. They have shown enormous potential, covering several important areas in our lives, and they are making our lives easier and better. Although viruses have already proven their potential, there is still a long road ahead. This prompt us to propose this theme in the Special Issue “The application of viruses to biotechnology”. We believe that the articles gathered here highlight recent significant advances in the use of viruses in several fields, contributing to the current knowledge on virus applications.

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Viral Related Tools against SARS-CoV-2

Cited by 3 publications

References 136 publications

The Study about Relationship of Direct Form of Topological Indices via M-Polynomial and Computational Analysis of Dexamethasone

The Study about Relationship of Direct Form of Topological Indices via M-Polynomial and Computational Analysis of Dexamethasone

Discovery of Antivirals Using Phage Display

An Overview of the Application of Viruses to Biotechnology

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