Viral Pneumonias

Human Nonspecific Effector Leukocytes: Possible Function in Herpes simplex Virus Infection

“…Some of them ob served preferential killing of HSV-infected cells versus uninfected cells [61,[88][89][90][91][92][93][94][95][96], but others did not [97], Some investigators found the increased lysis of HSV-1-infected cells only in individuals with evidence of a previous HSV infection [61,[88][89][90][91], MollerLarsen et al [70] suggested that these effects might be caused by anti-HSV cytophilic anti body, and found that the increased cytotoxicactivity of the effector cells from patients with previous HSV infection could be re duced by repeated washing of the cells. In other words, these authors thought that the enhanced killing seen in patients with recur rent infections is due not to better intrinsic effector cell activity but rather to the pres ence of anti-HSV antibodies on the effector cells.…”

Pulmonary Viral Infections in the Immunocompromised Host

“…The lungs are the primary site involved in life-threatening infections and several investigators have reviewed the general approach to diagnosis and management of pulmonary infections in the immunocompromised host. [1][2][3][4][5][6][7] Despite the large number of human respiratory viruses and frequent viral respiratory infections in normal hosts, there are relatively few viruses that have caused pulmonary disease in immunocompromised patients. The viruses involved are primarily those of the herpes group: cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella-zoster virus (VZV).…”