Viral oncolysates in patients with advanced ovarian cancer

Freedman, Ralph S.; Edwards, Creighton L.; Bowen, James M.; Lotzová, Eva; Katz, Ruth L.; Lewis, Errol; Atkinson, Neely; Carsetti, Rita

doi:10.1016/0090-8258(88)90233-8

Cited by 35 publications

(14 citation statements)

References 20 publications

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“…Viral lysates (called oncolysate) have been used in the past to vaccinate human against cancer (45). Those few trials have shown some degrees of success, but results have been ambiguous (39,46,47). Remarkably, treatment with viral oncolysates showed better overall survival than radio-and chemotherapy, probably because of the harmful effects that these conventional therapies have on the immune system (48).…”

Section: Discussionmentioning

confidence: 99%

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Oncolytic poliovirus therapy and immunization with poliovirus-infected cell lysate induces potent antitumor immunity against neuroblastoma in vivo

Toyoda

Wimmer²,

Cello³

2010

Int J Oncol

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Abstract. In a previous study, we demonstrated that neuroblastoma subcutaneously implanted in immuno-competent mice is eliminated by intratumoral administration of neuroattenuated poliovirus (PV). Our results also suggested that the in vivo destruction of neuroblastoma cells by virotherapy lead to a robust antitumor immune response. In this work, splenocytes harvested from neuroblastoma-bearing animals treated with neuroattenuated PV exhibited significantly higher lytic activity against tumor target cells than did those from splenocytes derived from control mice. In vitro T-cell depletion experiments indicated that CD8 + T cells were essential for the cytotoxic antitumor activity of splenocytes. Moreover, adoptive transfer of splenocytes obtained from mice cured of neuroblastoma by PV virotherapy markedly delayed the tumor growth of previously established neuroblastomas in recipient naïve mice. These results confirmed that treatment with a neuroattenuated oncolytic PV strain induces antitumor immunity against neuroblastoma that is mainly mediated by cytotoxic CD8 + T cells. Immunocompetent mice, on the other hand, were immunized with PV-infected neuroblastoma cell lysate prior intravenous challenge with neuroblastoma cells. As a control, mice were vaccinated with either non-infected neuroblastoma cell lysate alone or mixed with PV, or with PBS prior tumor cell injection. Results showed that survival is significantly prolonged only in mice immunized with PV-infected tumor lysate. This finding clearly suggested that in vitro poliovirus infection of neuroblastoma cells turns these cells into a potent tumor immunogen. Further studies in oncolytic treatment of neuroblastoma using attenuated PV alone or in combination with immunotherapy with PV oncolysate should improve the probability for successful translation in the clinic.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oncolytic poliovirus therapy and immunization with poliovirus-infected cell lysate induces potent antitumor immunity against neuroblastoma in vivo

Toyoda

Wimmer²,

Cello³

2010

Int J Oncol

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show abstract

“…Preclinical data suggest that influenza virus has significant oncolytic activity, 155 but neurologic toxicity complicates the possibility of using this virus as a systemic therapeutic. 156 Thus, clinical investigation of influenza virus has focused on ex vivo use in which the virus is exposed to malignant cells in order to induce oncolysis.…”

Section: Influenza Virusmentioning

confidence: 99%

Selectively replicating viral vectors

Nemunaitis

Edelman

2002

Cancer Gene Ther

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“…Viral lysates (called oncolysate) have been used in the past to vaccinate human against cancer (Sinkovics & Horvth, 2006). Those few trials have shown some degrees of success, but results have been ambiguous (Cassel & Murray, 1992;Freedman et al, 1988;Murray et al, 1977). Remarkably, treatment with viral oncolysates showed better overall survival than radio-and chemo-therapy, probably because of the harmful effects of conventional therapies has on the immune system (White et al, 2002).…”

Section: Oncolytic Poliovirus For Treatment Of Neuroblastoma: Preclinmentioning

confidence: 99%

“…A number of molecules released from dying cells have been identified to elicit immune signaling during immunogenic cell death. These include, among others, high mobility group box 1 (HMGB1, also known as amphoterin), purine metabolites (uric acid), calreticulin (CRT), and heat shock proteins (HSP) (Freedman et al, 1988;Obeid et al, 2007a;Shi et al, 2003;Udono & Srivastava, 1994). Induction of HSP is one of the earliest indications of cellular stress following infection with both RNA and DNA viruses (Asea, 2007;Liu et al, 2008).…”

Section: Oncolytic Poliovirus For Treatment Of Neuroblastoma: Preclinmentioning

confidence: 99%

Oncolytic Poliovirus Therapy in a Mouse Model of Neuroblastoma: Preclinical Data Analysis and Future Studies

Toyoda¹,

Wimmer²,

Cello³

2012

Neuroblastoma - Present and Future

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Viral oncolysates in patients with advanced ovarian cancer

Cited by 35 publications

References 20 publications

Oncolytic poliovirus therapy and immunization with poliovirus-infected cell lysate induces potent antitumor immunity against neuroblastoma in vivo

Oncolytic poliovirus therapy and immunization with poliovirus-infected cell lysate induces potent antitumor immunity against neuroblastoma in vivo

Selectively replicating viral vectors

Oncolytic Poliovirus Therapy in a Mouse Model of Neuroblastoma: Preclinical Data Analysis and Future Studies

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