2020
DOI: 10.1186/s12866-020-01817-4
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Viral metagenomic analysis of fecal samples reveals an enteric virome signature in irritable bowel syndrome

Abstract: Background: Changes in the enteric microbiota have been suggested to contribute to gastrointestinal diseases, including irritable bowel syndrome. Most of the published work is on bacterial dysbiosis with meager data on the role of the virome in irritable bowel syndrome and other gastrointestinal diseases. In the current study, we therefore aimed to investigate the viral community composition of the gut and test for potential dysbiosis linked to irritable bowel syndrome. Results: A metagenomics analysis on feca… Show more

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Cited by 27 publications
(19 citation statements)
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“…The larger study presented here examines both known and unknown viral sequences. We corroborated the reduction in phage alpha diversity in IBS and lack of robust differentiation among IBS subtypes reported by Ansari et al 25 However, we did not identify significant differences in families of eukaryotic viruses of the order Megavirales between patients with IBS and controls, as reported by Ansari et al 25 with the exception of two VCs assigned to the Mimiviridae family, one of which was more abundant in IBS and one with less abundance but we noted that the protein sequence hits used to classify this family had low support. All other members of the Megavirales order in our data had very low abundances and alignment scores and did not display significantly different abundances between IBS and controls.…”
Section: Discussionsupporting
confidence: 92%
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“…The larger study presented here examines both known and unknown viral sequences. We corroborated the reduction in phage alpha diversity in IBS and lack of robust differentiation among IBS subtypes reported by Ansari et al 25 However, we did not identify significant differences in families of eukaryotic viruses of the order Megavirales between patients with IBS and controls, as reported by Ansari et al 25 with the exception of two VCs assigned to the Mimiviridae family, one of which was more abundant in IBS and one with less abundance but we noted that the protein sequence hits used to classify this family had low support. All other members of the Megavirales order in our data had very low abundances and alignment scores and did not display significantly different abundances between IBS and controls.…”
Section: Discussionsupporting
confidence: 92%
“…To our knowledge, there is a single previous report on the gut virome in IBS 25 which investigated the fecal virome of 25 patients with IBS and 17 controls using the subset of reads that could be classified to known viral families by alignment to the Viral RefSeq database. The larger study presented here examines both known and unknown viral sequences.…”
Section: Discussionmentioning
confidence: 99%
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“…The detrimental effects of CsCl should be avoided to maintain diversity and integrity as much as possible. Additionally, even though sequencing has introduced a wealth of information regarding phage constituents within the microbiome [ 39 , 40 , 41 , 42 , 43 ], it has become apparent that there is a need to move into research that investigates the activity of said phage populations in relation to health and dysbiosis. As such, it is even more important to retain not only the community structure, but the activity.…”
Section: Discussionmentioning
confidence: 99%
“…HIV, HPV, HBV, HCV, EBV and IBS-V are associated with ILD, fibrosis and immunological cancers. [3][4][5][6][7] The coronavirus is also associated with ILD and pulmonary fibrosis, suggesting that this virus may play a role in the higher mortality of patients with cancer. [8][9][10] Statins have multiple pleiotropic effects (eg, suppression of inflammation, reduction of oxidative stress and reduction of T cell activation) that have implications for immunomodulatory diseases.…”
Section: Introductionmentioning
confidence: 99%