Viral Loads among Young HIV-Infected Men with Early Syphilis

Taylor, Melanie; Li, Whitney Y.; Skinner, Julia; Mickey, Tom

doi:10.1177/2325957414536229

Cited by 10 publications

(6 citation statements)

References 14 publications

(23 reference statements)

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“…In addition, in our study among the group of young men coinfected with HIV and early syphilis, many had detectable VLs collected near the time of syphilis diagnosis, suggesting the probability of HIV transmission. The same applies to the study of Centers for Disease Control and Prevention 15 and Taylor et al 32 Some researchers suggest the immediate initiation of ART in seropositive MSM with syphilis coinfection and high VL, in order to reduce the chances of HIV transmission. 33 Genotypic testing of samples from the five patients receiving ART and who experienced increased VL after syphilis treatment in this study revealed development of viral mutations that conferred resistance to antiretroviral drugs.…”

Section: Discussionmentioning

confidence: 96%

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Early syphilis affects markers of HIV infection

et al. 2016

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The objective of this study was to investigate if early syphilis infection affects markers of HIV infection; CD4 T cells and viral load (VL). A retrospective study was performed on 160 HIV-positive patients (111 receiving antiretroviral therapy [ART] and 49 without ART). Early syphilis diagnosis was made in HIV patients during their follow-up at the HIV/AIDS Unit at a Greek Dermatology and Venereology Unit. The patients' blood tests were available at the time of diagnosis, as well as before and 12 weeks after early syphilis diagnosis. CD4 T cell counts and VL levels were measured. It was found that syphilis infection had a negative impact on the CD4 T cell counts in both groups, with reduced CD4 T cell counts observed in 84.6% (99/111) and 79.5% (39/49) of patients receiving and not receiving ART, respectively. After treatment for syphilis, CD4 T cell counts returned to pre-treatment levels in most patients, especially those receiving ART. There was a slight and transient VL increase. Patients receiving ART had a 27% increase in VL, compared to 71.4% among patients not receiving ART. Although the VL increase was slight (41-14,000 copies/ml) in the group under treatment, 4-5% (5/111) patients did not return to pre-treatment levels. Moreover, viral mutations associated with treatment resistance were identified in these patients. Early syphilis accelerates and complicates the progression of HIV infection. Early diagnosis and treatment of syphilis may prevent infection-associated complications in most instances. Consequently, prevention of syphilis and other sexually transmitted infections is of great importance for patients infected with HIV.

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Section: Discussionmentioning

confidence: 96%

“…The same applies to the study of Centers for Disease Control and Prevention 15 and Taylor et al. 32 Some researchers suggest the immediate initiation of ART in seropositive MSM with syphilis coinfection and high VL, in order to reduce the chances of HIV transmission. 33…”

Section: Discussionmentioning

confidence: 96%

Early syphilis affects markers of HIV infection

et al. 2016

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“…8 Reciprocally, syphilis enhances the likelihood of HIV transmission 9 since it can negatively impact the immune system, and has been shown to increase HIV viral loads and reduce CD4 + T cell counts in PLWHA receiving ART. [10][11][12][13][14] The relationship between HIV/syphilis co-infection and treatment responses after initiation of ART has not been fully investigated. Thus, the aim of this study was to evaluate the impact of syphilis on the virologic (HIV viral load) and immunologic (CD4 counts, CD4/CD8 ratio) parameters of PLWHA, before and after initiation of ART.…”

Section: Introductionmentioning

confidence: 99%

Consequences of HIV/Syphilis Co-Infection on HIV Viral Load and Immune Response to Antiretroviral Therapy

Fan¹,

Yu²,

Zhang³

et al. 2021

IDR

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Introduction: Although syphilis is a frequent co-infection in patients with human immunodeficiency virus (HIV) infection, the influence of syphilis on immune response and virologic failure in HIV-infected patients following initiation of antiretroviral therapy (ART) is not well-defined. Methods: A retrospective study was conducted at Tianjin Second People's Hospital to evaluate the prevalence of syphilis and immune status in 4171 ART-naïve patients. The study included patients who initiated ART between August 2009 and June 2019. Results: The prevalence of syphilis was 40.1% in all ART-naïve patients and 42.5% in ARTnaïve men who have sex with men. HIV/syphilis co-infection was associated with higher virologic failure (odds ratio (95% confidence interval): 1.30 (1.04, 1.63)). Patients with HIV/ syphilis co-infection had lower median CD4 + T cell counts and CD4/CD8 ratios at baseline. After initiation of ART, patients co-infected with HIV/syphilis had smaller increases in CD4 + T cell counts and CD4/CD8 ratios than patients infected only with HIV. The rate of recurrence of syphilis or reinfection was 9% (n = 128) during seven years of ART. Conclusion: HIV/syphilis co-infection had a negative impact on immune recovery and antiretroviral effectiveness. RPR titer and HIV viral load should be monitored in patients coinfected with HIV/syphilis, especially in patients with high RPR titers.

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“…Além das consequências diretas, há extensa evidência que a sífilis facilita o risco de transmissão do HIV, seja por representar um marcador de comportamentos de risco para sua transmissão, seja pelo aumento da transmissibilidade decorrente da quebra da barreira cutânea e da presença de células inflamatórias ao nível das lesões cutaneomucosas (Lafond & Lukehart, 2006;Carlson & Dabiri & Cribier & Sell, 2011;Cohen & Klausner & Engelman & Philip, 2013;Taylor & Li & Skinner & Mickey, 2014).…”

Section: Introductionunclassified

Uma revisão das técnicas de detecção molecular de Treponema pallidum, qual a mais eficaz

Grassi

Rossetti

2021

RSD

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A sífilis é uma doença polimórfica, infectocontagiosa e sistêmica, causada pela bactéria T. pallidum, considerada um agravo de notificação compulsória. O diagnóstico precoce é um fator importante no seu controle, este é realizado combinando achados clínicos e exames laboratoriais. As técnicas moleculares ajudam no diagnóstico, no entanto, não se tem um consenso sobre qual técnica é a mais adequada, estudos apresentam divergências como, qual gene deve ser usado como alvo, qual sequência dos primers, método de extração e tipo de amostra. Esta revisão procurou investigar com base nas evidências científicas, as técnicas moleculares mais eficazes na detecção de DNA de Treponema pallidum. Para tanto, realizou-se uma revisão sistemática da literatura realizada nas bases de dados PubMed, Science Direct e Lilacs, através dos descritores “sífilis” and “PCR and “diagnóstico” and “biologia molecular”, selecionando trabalhos publicados nos últimos dez anos. A amostra foi composta por 10 artigos. Quanto ao desenho de estudo, o ensaio clínico foi 100% prevalente. Quanto ao método utilizado foi evidenciado variações, 6 utilizaram PCR Nested, 5 PCR em tempo real e 4 PCR convencional, 5 utilizam mais de uma variação. A diferença entre elas, como, tempo para avaliar uma reação, chance de contaminação, reprodutibilidade, especificidade, sensibilidade, precisão e acurácia diagnóstica, mostrou que os dois genes de maior interesse são o pol A e o tpp47. Os testes moleculares em especial o PCR nested demostrou ser promissor tendo boa sensibilidade e especificidade no diagnóstico da sífilis em conjunto com a sorologia para evitar complicações clínicas e transmissão da doença.

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Viral Loads among Young HIV-Infected Men with Early Syphilis

Cited by 10 publications

References 14 publications

Early syphilis affects markers of HIV infection

Early syphilis affects markers of HIV infection

Consequences of HIV/Syphilis Co-Infection on HIV Viral Load and Immune Response to Antiretroviral Therapy

Uma revisão das técnicas de detecção molecular de Treponema pallidum, qual a mais eficaz

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