Viral Kinetic Correlates of Cytomegalovirus Disease and Death after Hematopoietic Cell Transplant

Duke, Elizabeth R; Gilbert, Peter B.; Stevens-Ayers, Terry; Golob, Jonathan L.; Cossrow, Nicole; Marks, Morgan A.; Wan, Hong; Mast, T. Christopher; Huang, Meei‐Li; Jerome, Keith R.; Corey, Lawrence; Schiffer, Joshua T.; Boeckh, Michael

doi:10.1016/j.bbmt.2017.12.006

Cited by 3 publications

(3 citation statements)

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“…For numerous viral infections, including influenza, viral load correlates with disease severity and secondary household attack rate [7][8][9] . Early studies suggest that peak viral load differentiates mild from severe COVID-19 10 .Furthermore, viral load monitoring during antiviral therapy is a mainstay for various human infections including HIV, hepatitis B, cytomegalovirus and hepatitis C infections [11][12][13][14][15][16][17] . Particularly for viruses such as SARS-CoV-2 for which severe clinical outcomes occur in a minority of patients, viral load may serve as a useful surrogate marker to design smaller, but still sufficiently powered treatment studies 4,10 .…”

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confidence: 99%

Reliability of Self-Sampling for Accurate Assessment of Respiratory Virus Viral and Immunologic Kinetics

Waghmare

Krantz

Baral

et al. 2020

The Journal of Infectious Diseases

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The SARS-CoV-2 pandemic demonstrates the need for accurate and convenient approaches to diagnose and therapeutically monitor respiratory viral infections. We demonstrated that self-sampling with foam swabs is well-tolerated and provides quantitative viral output concordant with flocked swabs. Using longitudinal home-based self-sampling, we demonstrate nasal cytokine levels correlate and cluster according to immune cell of origin. Periods of stable viral loads are followed by rapid elimination, which could be coupled with cytokine expansion and contraction. Nasal foam swab self-sampling at home provides a precise, mechanistic readout of respiratory virus shedding and local immune responses.

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confidence: 99%

Reliability of Self-Sampling for Accurate Assessment of Respiratory Virus Viral and Immunologic Kinetics

Waghmare

Krantz

Baral

et al. 2020

The Journal of Infectious Diseases

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“…The challenge to mitigate the multifaceted consequences of CMV in transplantation has been a driving force in clinical virology, immunology, and drug development, and advances in these fields have led to our enhanced understanding of CMV. Establishing that asymptomatic CMV replication (expressed as viremia or DNAemia) correlates with CMV end-organ disease and death in HCT recipients enabled the use of CMV viremia (or the initiation of preemptive therapy) as a surrogate endpoint in clinical trials for the evaluation of CMV antivirals in HCT recipients [5].…”

Section: (See the Major Article By Ljungman Et Al On Pages 1525-33)mentioning

confidence: 99%

“…The impact of letermovir exposure on viral kinetics merits further study. In a recent meta-analysis of viral kinetics during preemptive therapy, the maximum viral load and duration of viral load correlated with death [5]. In the letermovir Phase III trial, among patients with early cs-CMV-i (by Week 14 post-HCT), 84% of letermovir recipients had the maximum CMV viral load of <1000 IU/mL, compared to 28% of placebo recipients, suggesting potential differences in viral load kinetics [7].…”

Section: (See the Major Article By Ljungman Et Al On Pages 1525-33)mentioning

confidence: 99%

Cytomegalovirus Viremia and Death After Hematopoietic Cell Transplantation: More Complex Than “To Have and Have Not”?

Perales

Papanicolaou

2019

Clinical Infectious Diseases

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Reliability of self-sampling for accurate assessment of respiratory virus viral and immunologic kinetics

Waghmare

Krantz

Baral

et al. 2020

Preprint

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1The SARS-CoV-2 pandemic demonstrates the need for accurate and convenient approaches to 2 diagnose and therapeutically monitor respiratory viral infections. We demonstrated that self-3 sampling with foam swabs is well-tolerated and provides quantitative viral output concordant 4 with flocked swabs. Using longitudinal home-based self-sampling, we demonstrate nasal 5 cytokine levels correlate and cluster according to immune cell of origin. Periods of stable viral 6 loads are followed by rapid elimination, which could be coupled with cytokine expansion and 7 contraction using mathematical models. Nasal foam swab self-sampling at home provides a 8 precise, mechanistic readout of respiratory virus shedding and local immune responses. 9Here we report data on a novel respiratory virus detection method using self-collected nasal 62 foam swabs. This methodology expands our testing armamentarium with easily collected and 63 comfortable swabs that can be applied to viral load and cytokine kinetic studies. Most 64 importantly, they can be easily scaled and used at home in this time of severe testing shortages 65 and dangerous transmission risk. 66 67

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Viral Kinetic Correlates of Cytomegalovirus Disease and Death after Hematopoietic Cell Transplant

Cited by 3 publications

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Reliability of Self-Sampling for Accurate Assessment of Respiratory Virus Viral and Immunologic Kinetics

Reliability of Self-Sampling for Accurate Assessment of Respiratory Virus Viral and Immunologic Kinetics

Cytomegalovirus Viremia and Death After Hematopoietic Cell Transplantation: More Complex Than “To Have and Have Not”?

Reliability of self-sampling for accurate assessment of respiratory virus viral and immunologic kinetics

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