Viral infection following kidney transplantation: Long-term follow-up in a single center

Hwang, Eun‐Sun; Kang, Min-Chul; Han, Seungyeup; Park, S.B.; Kim, H.C.

doi:10.1016/j.transproceed.2004.08.008

Cited by 32 publications

(27 citation statements)

References 6 publications

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“…Despite advances in immunosuppressive regimens over the past decade, infectious complications after kidney transplantation remain an important cause of morbidity and mortality (Hwang et al , 2004). In the present work fungal species were the most frequent organism, followed by herpes simplex.…”

Section: Discussionmentioning

confidence: 99%

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Oral health in renal transplant recipients administered cyclosporin A or tacrolimus

Spolidório¹,

Spolidório²,

Massucato³

et al. 2006

Oral Diseases

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Section: Discussionmentioning

confidence: 99%

“…No HSV was observed in the renal allograft recipients treated with FK‐506. Recent findings suggest that viral infection has always been a major threat to kidney transplant subjects on immunosuppressive therapy (Hwang et al , 2004). These results are not in accordance with the findings of the present work.…”

Section: Discussionmentioning

confidence: 99%

Oral health in renal transplant recipients administered cyclosporin A or tacrolimus

Spolidório¹,

Spolidório²,

Massucato³

et al. 2006

Oral Diseases

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“…For example, of the total 335 influenza A virus infected patients being diagnosed upon admission to ErasmusMC - a tertiary university hospital - between August 2009 and July 2012, 113 (34%) had an underlying condition that classified them as being immunocompromised [11]. Since immunocompromised patients are more likely to acquire influenza [12], [13], showing relatively high influenza-associated mortality [4], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], effective antiviral prophylaxis and treatment protocols are of crucial importance for these patients.…”

Section: Introductionmentioning

confidence: 99%

Prolonged Influenza Virus Shedding and Emergence of Antiviral Resistance in Immunocompromised Patients and Ferrets

et al. 2013

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Immunocompromised individuals tend to suffer from influenza longer with more serious complications than otherwise healthy patients. Little is known about the impact of prolonged infection and the efficacy of antiviral therapy in these patients. Among all 189 influenza A virus infected immunocompromised patients admitted to ErasmusMC, 71 were hospitalized, since the start of the 2009 H1N1 pandemic. We identified 11 (15%) cases with prolonged 2009 pandemic virus replication (longer than 14 days), despite antiviral therapy. In 5 out of these 11 (45%) cases oseltamivir resistant H275Y viruses emerged. Given the inherent difficulties in studying antiviral efficacy in immunocompromised patients, we have infected immunocompromised ferrets with either wild-type, or oseltamivir-resistant (H275Y) 2009 pandemic virus. All ferrets showed prolonged virus shedding. In wild-type virus infected animals treated with oseltamivir, H275Y resistant variants emerged within a week after infection. Unexpectedly, oseltamivir therapy still proved to be partially protective in animals infected with resistant virus. Immunocompromised ferrets offer an attractive alternative to study efficacy of novel antiviral therapies.

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“…Although in some studies no correlation has been found between grades and stages of chronic hepatitis C and specific genotypes [24], some authors demonstrated that an enhancement in viral diversities may be associated with the prognosis of liver disease [25]. The results of some studies conducted in the USA and Spain indicated that HCV genotype distribution in renal transplant recipients is similar to that in non-renal patients [11,17]. In some reports from Spain, Japan and Germany, it has been demonstrated that the most frequent genotype in kidney allograft recipients was 1b [14,17,19].…”

Section: Genotypesmentioning

confidence: 99%

Hepatitis C and renal transplantation: a review on historical aspects and current issues

Moghaddam

Alavian

Kermani

2008

Reviews in Medical Virology

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Chronic liver disease has a significant impact on the survival of renal transplant recipients with an incidence rate of 4-38%. Approximately, 8-28% of renal transplant recipients die due to chronic liver disease. Hepatitis C seems to be the leading cause of chronic liver disease in kidney recipients. Hepatitis C virus (HCV) infection has a wide range of prevalence (2.6-66%) among renal transplant recipients living in different countries with great genotype diversity in different parts of the world. Nowadays, antiviral drugs are used for the management of hepatitis C. Because of graft-threatening effects of some antiviral drugs used in HCV-infected renal transplant recipients, we specifically focused on HCV treatment after renal transplantation. Treatment of post-renal transplantation chronic liver disease with INF and ribavirin remains controversial. Anecdotal reports on post-renal transplantation hepatitis C demonstrate encouraging findings. This review summarises the most current information on diagnosis, treatment, prognosis, complications as well as the new aspects of treatment in HCV-infected renal transplant recipients. HCV belongs to the family of Flaviviridae, genus Hepacivirus.

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Viral infection following kidney transplantation: Long-term follow-up in a single center

Cited by 32 publications

References 6 publications

Oral health in renal transplant recipients administered cyclosporin A or tacrolimus

Oral health in renal transplant recipients administered cyclosporin A or tacrolimus

Prolonged Influenza Virus Shedding and Emergence of Antiviral Resistance in Immunocompromised Patients and Ferrets

Hepatitis C and renal transplantation: a review on historical aspects and current issues

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