“…HHV8 vGPCR is a seven span transmembrane constitutively active receptor coupled to a heterotrimeric G protein, whose closest homologue is the chemokine receptor CXCR2 (Bais et al, 1998). At the molecular level, mitogenactivated protein kinases, Akt, Rac GTPase and NF-kB signaling pathways could be controlled by vGPCR without the need for further extracellular activation (Sodhi et al, 2000(Sodhi et al, , 2004aMontaner et al, 2001Montaner et al, , 2004. Of note, vGPCR expression triggers proliferation, survival and migration of endothelial cells in vitro, and is associated with paracrine secretion of diverse cytokines (Montaner et al, 2004).…”