Viral hepatitis: Global goals for vaccination

Socio-demographic and behavioral determinants of hepatitis B vaccination and infection in pregnant women on Mayotte Island, Indian Ocean

“…Safe and effective vaccines are widely available for the prevention of HBV infection, morbidity and mortality [1,2,6,[10][11][12]. However, management of HBV infection during pregnancy is complicated by the potential risk of HBV transmission to fetuses [1,[13][14][15].…”

“…PW must be immunized to protect them and their born children from HBV infection. Otherwise, babies born to HBVinfected mothers should receive hepatitis B immunoglobulin at birth to reduce vertical transmission [1,2,6,[10][11][12].…”

In vitro and in vivo replication of a chemically synthesized consensus genome of hepatitis B virus genotype B

“…Therefore, treatment and control of HBV infection remains a major public health challenge in the 21st century (Fattovich et al, 2008;El-Serag, 2012;Lavanchy, 2012). A lack of proofreading activity in DNA-and RNA-dependent DNA polymerases results in nucleotide misincorporation during HBV replication.…”

Molecular Virology of Hepatitis B Virus and Targets for Antiviral Intervention

“…HBV infection can lead to acute and chronic liver disease. Worldwide, more than 240 million people are currently chronic HBV carriers [1], and more than 620,000 die annually from the long-term sequelae of this disease, despite the fact that the infection is preventable by a protective vaccine that has been available worldwide for over 25 years [2]. Vaccination can especially protect newborns from one of the major natural transmission routes that keep this blood-borne virus within the human community: vertical transmission from chronic HBV-infected mother to the child at birth.…”