Viral Hepatitis Among Drug Users in Methadone Maintenance: Associated Factors, Vaccination Outcomes, and Interventions

Perlman, David C.; Jordan, Ashly E.; McKnight, Courtney; Young, Christopher; Delucchi, Kevin; Sorensen, James L.; Jarlais, Don C. Des; Masson, Carmen L.

doi:10.1080/10550887.2014.969623

Cited by 13 publications

(9 citation statements)

References 40 publications

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“…In addition to prevention, OMT offers opportunities for hepatitis testing and treatment (Perlman et al, 2014). In our study, the rate of HCV assessments was very high (92.5%), and current hepatitis C status was known from 78.6% of those patients with HCV antibodies.…”

Section: Discussionmentioning

confidence: 80%

Outcomes of Patients in Long-Term Opioid Maintenance Treatment

Zippel-Schultz

Specka

Cimander³

et al. 2016

Substance Use & Misuse

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The sample as a whole was characterized by stable living conditions, high unemployment, low illicit opiate use, and a high retention rate. Continuation of OMT could enable further treatment of comorbidity and prevent resumption of a drug-dominated lifestyle. But it may well be asked how within the context of OMT further improvements can be achieved, especially with regard to further decrease of alcohol use and the treatment of depression.

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Section: Discussionmentioning

confidence: 80%

Outcomes of Patients in Long-Term Opioid Maintenance Treatment

Zippel-Schultz

Specka

Cimander³

et al. 2016

Substance Use & Misuse

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“…Selection criteria, enrollment procedures, study interventions, and primary outcomes have been described previously (Dhingra et al, 2013; Larios et al, 2014; Masson et al, 2013; Perlman et al, 2014). All patients completed measures at baseline and 3, 9, and 12 months later.…”

Section: Methodsmentioning

confidence: 99%

“…A hepatitis care coordination trial provided an opportunity for a secondary analysis of pain-related data from two MMT programs (Masson et al, 2013; Perlman et al, 2014; Dhingra et al, 2013; Larios et al, 2014). Cross-sectional baseline data from this study revealed no statistically significant association between pain and illicit drug use behaviors (Dhingra et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal analysis of pain and illicit drug use behaviors in outpatients on methadone maintenance

Dhingra¹,

Perlman

Masson

et al. 2015

Drug and Alcohol Dependence

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Background Little is known about the experience of chronic pain and the occurrence of illicit drug use behaviors in the population enrolled in methadone maintenance treatment (MMT) programs. Methods This is a secondary analysis of longitudinal data from two MMT samples enrolled in a randomized controlled trial of hepatitis care coordination. Patients completed pain, illicit drug use, and other questionnaires at baseline and 3, 9, and 12 months later. Associations were sought over time between the presence or absence of clinically significant pain (average daily pain ≥ 4 or mean pain interference ≥ 4 during the past week) and current illicit drug use (i.e., non-therapeutic opioid, cocaine or amphetamine use identified from self-report or urine drug screening). Results Of 404 patients providing complete data, within-patient variability in pain and illicit drug use was high across the 4 assessment periods. While 263 denied pain at baseline, 118 (44.9%) later experienced clinically significant pain during ≥ 1 follow-up assessments. Of 180 patients (44.6%) without evidence of illicit drug use at baseline, only 109 (27.0%) had similar negative drug use at all follow-up assessments. Across four assessment periods, there was no significant association between pain group status and current illicit drug use. Conclusions This one-year longitudinal analysis did not identify a significant association between pain and illicit drug use in MMT populations. This finding conflicts with some earlier investigations and underscores the need for additional studies to clarify the complex association between pain and substance use disorders in patients in MMT program settings.

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“…L. Masson, et al, 2013) However, neither co-located models nor linkage models are widely implemented. (Bruggmann & Litwin, 2013; Masson, et al, 2013; Perlman, et al, 2014)…”

Section: United Statesmentioning

confidence: 99%

An international perspective on using opioid substitution treatment to improve hepatitis C prevention and care for people who inject drugs: Structural barriers and public health potential

Perlman

Jordan

Uusküla

et al. 2015

International Journal of Drug Policy

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People who inject drugs (PWID) are central to the hepatitis C virus (HCV) epidemic. Opioid substitution treatment (OST) of opioid dependence has the potential to play a significant role in the public health response to HCV by serving as an HCV prevention intervention, by treating non-injection opioid dependent people who might otherwise transition to non-sterile drug injection, and by serving as a platform to engage HCV infected PWID in the HCV care continuum and link them to HCV treatment. This paper examines programmatic, structural and policy considerations for using OST as a platform to improve the HCV prevention and care continuum in 3 countries—the United States, Estonia and Viet Nam. In each country a range of interconnected factors affects the use OST as a component of HCV control. These factors include 1) that OST is not yet provided on the scale needed to adequately address illicit opioid dependence, 2) inconsistent use of OST as a platform for HCV services, 3) high costs of HCV treatment and health insurance policies that affect access to both OST and HCV treatment, and 4) the stigmatization of drug use. We see the following as important for controlling HCV transmission among PWID: 1) maintaining current HIV prevention efforts, 2) expanding efforts to reduce the stigmatization of drug use, 3) expanding use of OST as part of a coordinated public health approach to opioid dependence, HIV prevention, and HCV control efforts, 4) reductions in HCV treatment costs and expanded health system coverage to allow population level HCV treatment as prevention and OST as needed. The global expansion of OST and use of OST as a platform for HCV services should be feasible next steps in the public health response to the HCV epidemic, and is likely to be critical to efforts to eliminate or eradicate HCV.

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Viral Hepatitis Among Drug Users in Methadone Maintenance: Associated Factors, Vaccination Outcomes, and Interventions

Cited by 13 publications

References 40 publications

Outcomes of Patients in Long-Term Opioid Maintenance Treatment

Outcomes of Patients in Long-Term Opioid Maintenance Treatment

Longitudinal analysis of pain and illicit drug use behaviors in outpatients on methadone maintenance

An international perspective on using opioid substitution treatment to improve hepatitis C prevention and care for people who inject drugs: Structural barriers and public health potential

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