Viral Hæmorrhagic Fever in Southern Sudan and Northern Zaire

Bowen, E. T. W.; Lloyd, Graham; Harris, William J.; Platt, G.S.; Baskerville, A.; Vella, E. E.

doi:10.1016/s0140-6736(77)92001-3

Cited by 237 publications

(118 citation statements)

References 3 publications

Supporting

Mentioning

116

Contrasting

Unclassified

Order By: Relevance

“…Along with MBGV, the four species of EBOV (Zaire, Sudan, Reston, Ivory Coast) make up the negative-stranded, enveloped RNA virus family Filoviridae. Acute mortality caused by the Zaire species of EBOV is approximately 80% in human outbreaks (Bowen et al, 1977;Johnson et al, 1977;Khan et al, 1999) and greater than 90% in monkey models of the genus Macaca Fisher-Hoch et al, 1992;Jaax et al, 1996;Geisbert et al, 2002). There is currently no vaccine or therapy for EBOV or MBGV HF approved for human use.…”

Section: Introductionmentioning

confidence: 99%

Filovirus Pathogenesis in Nonhuman Primates

Geisbert¹,

Jahrling²,

Larsen³

et al. 2002

View full text Add to dashboard Cite

Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information including suggestionsfor reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway Suile1204 Arlington, VA 22202-4302, and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188), Washington, DC 20503.

show abstract

Section: Introductionmentioning

confidence: 99%

Filovirus Pathogenesis in Nonhuman Primates

Geisbert¹,

Jahrling²,

Larsen³

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Along with Marburg virus (MBGV), the four species of EBOV (Zaire, Sudan, Reston, Ivory Coast) make up the negative-stranded, enveloped RNA virus family Filoviridae. Acute mortality caused by the Zaire species of EBOV is approximately 80% in human outbreaks [1][2][3] and greater than 90% in monkey models of the genus Macaca. 4 -7 There is currently no vaccine or therapy for EBOV or MBGV hemorrhagic fever approved for human use.…”

mentioning

confidence: 99%

Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques

Geisbert

Hensley

Larsen

et al. 2003

The American Journal of Pathology

530

327

View full text Add to dashboard Cite

Ebola virus (EBOV) infection causes a severe and fatal hemorrhagic disease that in many ways appears to be similar in humans and nonhuman primates; however, little is known about the development of EBOV hemorrhagic fever. In the present study, 21 cynomolgus monkeys were experimentally infected with EBOV and examined sequentially over a 6-day period to investigate the pathological events of EBOV infection that lead to death. Importantly, dendritic cells in lymphoid tissues were identified as early and sus-

show abstract

“…One infectious agent responsible for hemorragic fever is Ebola virus, named after a river in Africa where it was first recognized (1,2). One viral product is a secreted glycoprotein (sGP) 4 of 50 -70 kDa (3).…”

mentioning

confidence: 99%