Viral Etiology of acute respiratory tract infections in hospitalized children and adults in Shandong Province, China

Liu, Ti; Li, Zhong; Zhang, Shengyang; Song, Shaoxia; Wu, Julong; Lin, Yi Wen; Guo, Nongjian; Xing, Chengzhong; Xu, Aiqiang; Bi, Zhenqiang; Wang, Xianjun

doi:10.1186/s12985-015-0388-z

Cited by 64 publications

(75 citation statements)

References 35 publications

(47 reference statements)

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“…In our previous study, increased numbers of influenza cases were reported during the rainy and winter seasons of Nepal [7]. Similar findings were reported in Shandong Province, China [11], Bhutan [12], Indonesia [13], and ailand [14].…”

Section: Discussionsupporting

confidence: 82%

Etiology of Coinfections in Children with Influenza during 2015/16 Winter Season in Nepal

Upadhyay

Banjara

Shrestha

et al. 2018

International Journal of Microbiology

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Acute respiratory infections (ARIs) are one of the major public health problems in developing countries like Nepal. Besides the influenza, several other pathogens are responsible for acute respiratory infection in children. Etiology of infections is poorly characterized at the course of clinical management, and hence empirical antimicrobial agents are used. The objective of this study was to characterize the influenza and other respiratory pathogens by real-time PCR assay. A total of 175 throat swab specimens of influenza-positive cases collected at National Influenza Center, Nepal, during the 2015/16 winter season were selected for detecting other respiratory copathogens. Total nucleic acid was extracted using Pure Link viral RNA/DNA mini kit (Invitrogen), and multiplex RT-PCR assays were performed. Influenza A and B viruses were found in 120 (68.6%) and 55 (31.4%) specimens, respectively, among which coinfections were found in 106 (60.6%) specimens. Among the influenza A-positive cases, 25 (20.8%) were A/H1N1 pdm09 and 95 (79.2%) were A/H3 subtypes. Viruses coinfected frequently with influenza virus in children were rhinovirus (26; 14.8%), respiratory syncytial virus A/B (19; 10.8%), adenovirus (14; 8.0%), coronavirus (CoV)-HKU1 (14; 8.0%), CoV-OC43 (5; 2.9%), CoV-229E (2; 1.1%), metapneumovirus A/B (5; 2.9%), bocavirus (6; 3.4%), enterovirus (5; 2.9%), parainfluenza virus-1 (3; 1.7%), and parainfluenza virus-3 (2; 1.1%). Coinfection of Mycoplasma pneumoniae with influenza virus was found in children (5; 2.8%). Most of the viral infection occurred in young children below 5 years of age. In addition to influenza virus, nine different respiratory pathogens were detected, of which coinfections of rhinovirus and respiratory syncytial virus A/B were predominantly found in children. This study gives us better information on the respiratory pathogen profile and coinfection combinations which are important for diagnosis and treatment of ARIs.

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Section: Discussionsupporting

confidence: 82%

Etiology of Coinfections in Children with Influenza during 2015/16 Winter Season in Nepal

Upadhyay

Banjara

Shrestha

et al. 2018

International Journal of Microbiology

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“…Our data revealed a higher positive rate of total respiratory viruses 1617. As our hospital provides tertiary care, the disease severity of admitted children may be higher than other studies.…”

Section: Discussioncontrasting

confidence: 43%

Human Coronavirus in the 2014 Winter Season as a Cause of Lower Respiratory Tract Infection

et al. 2017

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PurposeDuring the late autumn to winter season (October to December) in the Republic of Korea, respiratory syncytial virus (RSV) is the most common pathogen causing lower respiratory tract infections (LRTIs). Interestingly, in 2014, human coronavirus (HCoV) caused not only upper respiratory infections but also LRTIs more commonly than in other years. Therefore, we sought to determine the epidemiology, clinical characteristics, outcomes, and severity of illnesses associated with HCoV infections at a single center in Korea.Materials and MethodsWe retrospectively identified patients with positive HCoV respiratory specimens between October 2014 and December 2014 who were admitted to Severance Children’s Hospital at Yonsei University Medical Center for LRTI. Charts of the patients with HCoV infection were reviewed and compared with RSV infection.ResultsDuring the study period, HCoV was the third most common respiratory virus and accounted for 13.7% of infections. Coinfection was detected in 43.8% of children with HCoV. Interestingly, one patient had both HCoV-OC43 and HCoV-NL63. Mild pneumonia was most common (60.4%) with HCoV, and when combined with RSV, resulted in bronchiolitis. Two patients required care in the intensive care unit. However, compared with that of RSV infection, the disease course HCoV was short.ConclusionInfections caused by HCoVs are common, and can cause LRTIs. During an epidemic season, clinicians should be given special consideration thereto. When combined with other medical conditions, such as neurologic or cardiologic diseases, intensive care unit (ICU) care may be necessary.

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“…Coinfections with different multiple viruses were reported in 15% to 61% of patients. [6][7][8][9]. Molecular techniques such as multiplex polymerase chain reaction (PCR) are widely used for the detection and identification of respiratory viruses [10][11][12] and are helpful in the management and treatment 2 BioMed Research International of respiratory infections [13].…”

Section: Introductionmentioning

confidence: 99%

Respiratory Tract Viral Infections and Coinfections Identified by Anyplex™ II RV16 Detection Kit in Pediatric Patients at a Riyadh Tertiary Care Hospital

Eifan

Hanif

Aljohani

2017

BioMed Research International

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Respiratory infections are caused by an array of viruses, and limited information is available about viral coexistence, comparative symptoms, and the burden of illness. This retrospective cohort study aimed to determine the etiological agents responsible for respiratory tract infections by Anyplex II RV16 detection kit (RV16, Seegene), involving 2266 pediatric patients with respiratory infections admitted to the Department of Pediatrics at King Abdul-Aziz Medical City, Ministry of National Guard, Riyadh, from July 2014 to June 2015. The most frequent respiratory infections were recorded in the 1 to 5 year age group (44.7%). Rhinovirus (32.5%), Adenovirus (16.9%), and Respiratory syncytial virus (RSV) B (10.4%) were most common. In single viral infections, Rhinovirus (41.2%), Metapneumovirus (15.3%), and Bocavirus (13.7%) were most frequent. In multiple viral infections, Rhinovirus (36.7%), Adenovirus (35.2%), Bocavirus (11.2), RSV B (7.8%), and RSV A (6.7%) were most frequent. No significant difference was observed in clinical presentations; however, rhinorrhea and hypodynamia were significantly associated with viral respiratory infections. Most respiratory viral pathogens peaked during December, January, March, and April. Rhinovirus, Adenovirus, and Bocavirus circulations were detected throughout the year. Winter peaks were recorded for Rhinovirus, RSV B, Adenovirus, and RSV A, whereas the Metapneumovirus, and the Bocavirus peaked in March and April. These findings enhance understanding of viral etiology and distribution to improve respiratory infection management and treatment.

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Viral Etiology of acute respiratory tract infections in hospitalized children and adults in Shandong Province, China

Cited by 64 publications

References 35 publications

Etiology of Coinfections in Children with Influenza during 2015/16 Winter Season in Nepal

Etiology of Coinfections in Children with Influenza during 2015/16 Winter Season in Nepal

Human Coronavirus in the 2014 Winter Season as a Cause of Lower Respiratory Tract Infection

Respiratory Tract Viral Infections and Coinfections Identified by Anyplex™ II RV16 Detection Kit in Pediatric Patients at a Riyadh Tertiary Care Hospital

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