Viral Etiology for Inner Ear Diseases: Proven, Unproven, Unlikely

Oliveira, Carlos Augusto de; Sampaio, André Luiz Franco; Bahmad, Fayez; Araújo, Mercêdes F. S.

doi:10.1159/000111047

Cited by 3 publications

(4 citation statements)

References 77 publications

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“…The idea that viruses, especially those of the Herpesviridae family, might contribute to the pathogenesis of MD has remain disputed for some time. The 2008 review of Oliviera and colleagues concluded it to be unlikely that MD had any demonstrable viral etiopathology [15]. On the other hand, contemporaneous work by Gacek concluded that overall, MD simply is the manifestation of viral-infection of the inner-ear [18].…”

Section: Discussionmentioning

confidence: 99%

“…From that perspective, it appears that viral-infections are undoubtedly relevant to MD. By contrast, as of 2008, drawing from an evidence base virtually the same as above, Oliviera and colleagues disputed there being any reliable evidence of a viral etiopathology in MD [19]. And more recently, Mirza and Gokhale judged that antiviral pharmacotherapy has had “no role in the treatment of MD” [20].…”

Section: Introductionmentioning

confidence: 99%

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Are viral-infections associated with Ménière’s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD

et al. 2019

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Despite considerable research, it remains controversial as to whether viral-infections are associated with Meniere’s Disease (MD), a clinically heterogeneous set of chronic inner-ear disorders strongly associated with endolymphatic hydrops. Here, we investigated whether viral-infections are associated with MD through a systematic review and meta-analysis of observational clinical studies using molecular-diagnostics. Eligible for inclusion were case-controlled studies which ascertained molecular-determinants of past or present viral-infection through either viral nucleic acids or host serological marker in MD cases and non-MD controls. Across online databases and grey literature, we identified 210 potentially relevant articles in the English language, from which a total of 14 articles fully satisfied our eligibility criteria such that meta-groups of 611 MD-cases and 373 controls resulted. The aggregate quality of the modest-sized (14 studies) body of evidence was limited and varied considerably with regards to participant selection, matching, and ascertainment(s) and determinant(s) of viral-infection. Most data identified concerned the human cytomegalovirus (CMV), and meta-analysis of eligible studies revealed that evidence of CMV-infection was associated approximately three-fold with MD compared to controls, however the timing of the infections was indeterminate as the pooled analyses combined antiviral serological markers with viral nucleic acid markers. No association was found for any of HSV-1, -2, VZV, or EBV. Associative analyses of any viral species not aforementioned were precluded by limited data, and thus potential associations between other viral species and MD, especially other than Herpesviridae, are yet to be characterised. Overall, we have found a small association between CMV-infection and MD, however it is to be determined for what sub-groups of MD this finding may be relevant, and ideally the reported association remains would be reproduced by a greater volume of higher quality evidence.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Are viral-infections associated with Ménière’s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD

et al. 2019

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“…Even though, so far, there is weak evidence of the impact of COVID-19 on the audio-vestibular system, post-viral hearing dysfunction is generally known [11,28]. However, no more high-quality research on temporary, acute impact, or long-term consequences on the auditory-vestibular system is available to date.…”

Section: Discussionmentioning

confidence: 99%

Self-Assessment of Hearing Using a Mobile App Among Covid-19 Patients

et al. 2022

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Introduction:The effect of SARS-CoV-2 on hearing has not been thoroughly examined. Factors limiting hearing tests in COVID-19 patients are hygiene requirements and the need to use specialized equipment. The objective of the study was to assess changes in hearing thresholds between diagnosis of COVID-19 and convalescence using a mobile app. Material and methods:Patients with mild to moderate COVID-19 symptoms, who were isolating at home were enrolled in the study between 1 September 2020 and 31 January 2021. Subjects answered an online medical survey and self-assessed hearing thresholds using the Hearing Test TM mobile app (e-audiologia.pl). These procedures were done twice, once at the time of diagnosis and again 2 weeks after convalescence.Results: A total of 67 subjects were found eligible for the study. At most frequencies the patients' hearing did not differ between the first and second examinations; however, for 4 kHz, a statistically significant improvement in the hearing threshold was found (p = 0.05). Survey review revealed noticeable improvement (p = 0.001) over time in smell, taste, and nasal congestion. Conclusions:It seems that SARS-CoV-2 infection caused a transient and selective (at 4 kHz) hearing impairment in patients who had had mild to moderate infection. The results suggest that as olfactory function returns after COVID-19, an improvement in hearing can be expected. Solutions based on mobile technology are useful for monitoring the hearing of patients in a pandemic.

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“…Study results showed similar improvement of symptoms in both groups, meaning that there was no obvious difference between the treated and control groups and that there was no evidence of benefit from the antiviral solution. Greco et al [38,39] have suggested that antiviral pharmacotherapy has largely replaced surgical management for a subset of patients with Meniere's disease, but Oliveira et al disputed the existence of a viral etiology for Meniere's disease altogether.…”

Section: The Role Of Antiviral Therapy In Meniere's Diseasementioning

confidence: 99%

Infectious causes and mimickers of meniere's disease

Kurtzman

Sioshansi

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of review To review the evidence of a possible viral etiology of Meniere's disease, the role of antiviral therapy, as well as other infectious disease processes that may mimic Meniere's disease. Better understanding of the etiology of Meniere's disease and the role of various infectious disease processes may allow for more effective diagnosis and management. Recent findings There is evidence that viral infections – to Herpes simplex virus, cytomegalovirus, Epstein Barr virus, influenza, adenovirus, Coxsackie virus B, and Varicella Zoster Virus – may be involved in the development of Meniere's disease, however the evidence is inconsistent and the underlying mechanism remains theoretical. Nevertheless, antiviral therapy may be effective for a subset of patients with Meniere's disease. Lastly, other infectious diseases including Lyme disease and syphilis can present with symptoms similar to Meniere's disease. It is important to discern these from Meniere's disease to determine the appropriate treatment. Summary There is a paucity of high-quality evidence to support a viral etiology of Meniere's disease, and the current evidence appears circumstantial and inconsistent. Additional research is necessary to establish the mechanism and causative pathogens. Antiviral therapy may provide therapeutic benefit for a subset of patients with Meniere's disease. Furthermore, clinicians should be aware of other infectious mimics of Meniere's disease and include them in the differential diagnosis of patients presenting with Meniere's-like symptoms. Research on this subject continues to evolve, and data from these studies represent a growing repository of evidence that can be used to guide clinical decision-making.

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Viral Etiology for Inner Ear Diseases: Proven, Unproven, Unlikely

Cited by 3 publications

References 77 publications

Are viral-infections associated with Ménière’s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD

Are viral-infections associated with Ménière’s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD

Self-Assessment of Hearing Using a Mobile App Among Covid-19 Patients

Infectious causes and mimickers of meniere's disease

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