Viral diarrhea in children in Beijing, China

Qiao, Haiping; Nilsson, Mikael; Abreu, Elba Rubilar; Hedlund, Kjell‐Olof; Johansen, Kari; Zaori, Getu; Svensson, Lennart

doi:10.1002/(sici)1096-9071(199904)57:4<390::aid-jmv11>3.0.co;2-0

Cited by 86 publications

(44 citation statements)

References 35 publications

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“…This might partly be explained by the fact that older children acquired protective immunity during previous exposures to rotavirus and are therefore more resistant to infection with this agent (13,20). In addition to the age distribution of rotavirus infection, many studies have indicated a higher ratio of infected males to infected females (8,24,26,28,30). The ratio in our study was 1.9.…”

Section: Rotavirus Infectionmentioning

confidence: 44%

Diarrhea Caused by Rotavirus in Children Less than 5 Years of Age in Hanoi, Vietnam

et al. 2004

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Group A rotaviruses are the major cause of diarrhea in young children worldwide. From March 2001 to April 2002, 836 children less than 5 years of age were investigated in Hanoi, Vietnam. This included 587 children with diarrhea and 249 age-matched controls. Group A rotavirus was identified in 46.7% of the children with diarrhea and 3.6% of the controls, which was a significant difference. Within the diarrhea group, the highest prevalence was seen in children from 13 to 24 months of age, and the prevalence was higher in males than in females. The symptoms of acute diarrhea caused by rotavirus were watery diarrhea, vomiting, fever, and dehydration. A higher prevalence of rotavirus detection was obtained for children who had all of these symptoms, followed by those who had diarrhea with vomiting-dehydration, fever-dehydration, and dehydration. The high rates occurred from September to December, although the infection was encountered all year round. In 58 patients (21.2% of the rotavirus-infected children), rotavirus infection was detected in association with either diarrheagenic Escherichia coli or Shigella spp. The most frequent combinations were rotavirus-enteroaggregative E. coli and rotavirus-enteropathogenic E. coli. At least one enteropathogen was identified from about 64% percent of the samples. The bacterial infection may not have given rise to clinical symptoms of such severity. The present study demonstrates the burden of rotavirus diarrhea in Hanoi, Vietnam. Continuous surveillance of diarrhea caused by rotavirus in young children would play an important role in diagnosis, treatment, and prophylaxis in order to improve the health of children in Vietnam.

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Section: Rotavirus Infectionmentioning

confidence: 44%

Diarrhea Caused by Rotavirus in Children Less than 5 Years of Age in Hanoi, Vietnam

et al. 2004

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“…In our study, P [6] strains were identified in combination with G9 (35.5%), G4 (25.8%), G1 (22.6%), and G3 (16.1%) serotypes and accounted for 10.7% of all P-typed specimens. In the present study, eight P [9] strains were isolated from children in six regions, and all were serotype G1, in contrast to a single P [9]G3 isolate from Wuhan, Hubei Province, detected in 1995 (25). In total, only 37 (11.3%) specimens were nontypeable by use of genotype-specific primers to five human rotavirus genotypes, suggesting that other P genotypes might be present or that variants of known genotypes could not be amplified with these primers.…”

mentioning

confidence: 66%

Diversity of Rotavirus Strains among Children with Acute Diarrhea in China: 1998-2000 Surveillance Study

Fang

Yang

et al. 2002

J Clin Microbiol

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As part of a national rotavirus surveillance activity, we collected fecal specimens from 3,177 children with acute diarrhea in 10 regions of China between April 1998 and April 2000 and screened them for rotavirus. Rotavirus was detected in 41% (n ‫؍‬ 1,305) of specimens, and in these, G1 was the predominant serotype (72.6%), followed by G3 (14.2%), G2 (12.1%), G4 (2.5%), G9 (0.9%), and G untypeable (0.7%). Among 327 G-typed strains tested for P genotype, 14 different P-G combinations were identified, with the globally common strains P [8]G1, P[4]G2, P[8]G3, and P[8]G4 representing 75.6% of all typed rotavirus strains. Among the uncommon strains, 11 were P[6]G9, and others included P[6]G1, P[6]G3, and five novel P-G combinations (P[9]G1, P[4]G1, P[4]G3, P[4]G4, and P[8]G2).Our results indicate that while the common rotavirus strains remain predominant, the diversity of strains is much greater than was previously recognized.

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“…The incidence of norovirus infections in young children has been investigated in different regions worldwide. Several reports indicate that 7 to 9% of acute gastroenteritis cases among young children are caused by norovirus (12,16,20,22). However, other studies have reported higher incidence rates, ranging from 15.7 to 20% (6,11,18).…”

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confidence: 99%

Molecular Epidemiology of Norovirus Infections in Stockholm, Sweden, during the Years 2000 to 2003: Association of the GGIIb Genetic Cluster with Infection in Children

et al. 2005

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The incidence of norovirus-associated gastroenteritis and the molecular epidemiology of norovirus strains were studied during three seasons (2000-2001, 2001-2002, and 2002-2003) among patients of all ages, mainly from the Stockholm region in Sweden. A total of 3,252 fecal samples were analyzed by reverse transcription-PCR. The incidences of norovirus infection among adults were 23, 26, and 30% during the three seasons studied and 18, 11, and 15% among children 0 to 15 years of age. During the first season, all norovirus strains detected by PCR were typed either by reverse line blot hybridization or nucleotide sequence analysis. During the two successive seasons, a total of 60 norovirus-positive strains from the beginning, peak, and end of the seasons were selected for nucleotide sequence analysis. We identified two dominant norovirus variants over the seasons: a new norovirus variant, recently described as the GGIIb genetic cluster, dominated among children during the first season, and during the following two seasons, a GGII-4 variant dominated. Our data suggest that norovirus infections are common, not only among adults, but also among children, and that some strains may predominantly affect children.

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Viral diarrhea in children in Beijing, China

Cited by 86 publications

References 35 publications

Diarrhea Caused by Rotavirus in Children Less than 5 Years of Age in Hanoi, Vietnam

Diarrhea Caused by Rotavirus in Children Less than 5 Years of Age in Hanoi, Vietnam

Diversity of Rotavirus Strains among Children with Acute Diarrhea in China: 1998-2000 Surveillance Study

Molecular Epidemiology of Norovirus Infections in Stockholm, Sweden, during the Years 2000 to 2003: Association of the GGIIb Genetic Cluster with Infection in Children

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