“…However, this paradigm is not universal, and several studies have indicated a significant role for antigen-specific T cells in organ pathology. Thus, cellular injury as a consequence of T-cellmediated inflammation and/or the destruction of virus-infected target cells by cytotoxic T cells has been associated with pathology in several experimental models and human diseases, including lethal viral infections of the central nervous system (CNS) (4,6,8,9,19,21,24,44,45,50,58,65). Although the mechanisms by which T cells participate in the control of viral infection without causing collateral damage (such as neurological deficit) remain poorly defined, a consensus is that the development of tissue pathology coincides with a massive extravasation of mononuclear cells to the site of virus replication, a process regulated by the increased expression of adhesion molecules on the nearby vasculature (62,68).…”