Viral chemistry: the chemical functionalization of viral architectures to create new technology

Chen, Zhuo; Li, Na; Li, Shaobo; Dharmarwardana, Madushani; Schlimme, Anna Flarra Cole; Gassensmith, Jeremiah J.

doi:10.1002/wnan.1379

Cited by 55 publications

(59 citation statements)

References 119 publications

(164 reference statements)

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“…For instance, several strategies have been developed that place polymers on the surface of viral nanoparticles by either a graft-to or graft-from strategy. 99 These strategies have produced new hybrid bio-synthetic systems with enhanced pharmacokinetics and can modulate immune response. 100 On the other hand, polymeric growth from covalently bound sites on the surface of viral nanoparticles may interfere with antigen recognition.…”

Section: Possible Approaches To Access Other Viral Architecturesmentioning

confidence: 99%

Metal–Organic Frameworks for Cell and Virus Biology: A Perspective

et al. 2018

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Metal-organic frameworks (MOFs) are a class of coordination polymers, consisting of metal ions or clusters linked together by chemically mutable organic groups. In contrast to zeolites and porous carbons, MOFs are constructed from a building block strategy that enables molecular level control of pore size/shape and functionality. An area of growing interest in MOF chemistry is the synthesis of MOF-based composite materials. Recent studies have shown that MOFs can be combined with biomacromolecules to generate novel biocomposites. In such materials, the MOF acts as a porous matrix that can encapsulate enzymes, oligonucleotides, or even more complex structures that are capable of replication/reproduction (i.e., viruses, bacteria, and eukaryotic cells). The synthetic approach for the preparation of these materials has been termed "biomimetic mineralization", as it mimics natural biomineralization processes that afford protective shells around living systems. In this Perspective, we focus on the preparation of MOF biocomposites that are composed of complex biological moieties such as viruses and cells and canvass the potential applications of this encapsulation strategy to cell biology and biotechnology.

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Section: Possible Approaches To Access Other Viral Architecturesmentioning

confidence: 99%

Metal–Organic Frameworks for Cell and Virus Biology: A Perspective

et al. 2018

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“…Second, the surface chemistry of the organism can regulate the production of synthetic coatings with controlled composition and structure. [87] Living organisms such as viruses and cells have perfectly symmetric structures with interfacial features, such as uniform size, highly charged surface, and repeat functional groups, which ensure the formation of core-shell structures via the oriented nucleation and growth of minerals along the membrane structure. It is also possible for organisms to construct on-demand biomineralized compositions and structures via pretreatment with functional groups or using metabolic process.…”

Section: Rational Design Of Biomineralization-based Engineeringmentioning

confidence: 99%

Therapeutic Potential of Biomineralization‐Based Engineering

Wang

Xiao

Hao

et al. 2018

Advanced Therapeutics

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In nature, the biomineralization processes of living organisms produce a wide range of organic-inorganic hybrid materials to achieve various functions. In particular, egg shells can provide extra protection for embryos and maintain air exchange. Inspired by such phenomena, it is assumed that the engineering of organisms with biomimetic materials can lead to significant improvement in organism function. This review summarizes recent progress in biomineralization-based techniques for organism engineering, and demonstrates the therapeutic potential enabled by these techniques. The design and synthesis approaches of biomineralization-based engineering are systemically introduced to guide the controlled modification of different organisms including viruses, bacteria, cells, and proteins using in situ biomineralization, bottom-up self-assembly, chemical and genetic engineering. Tailored organisms promise delivery, protection, cell therapy, vaccine improvement as well as therapeutic detection and imaging. The present review aims to propose a biomineralization-based strategy to promote functional evolution of these organisms, which promises to meet the increasing demand for new therapeutic purpose.

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“…To overcome this, we exploited a method to dual functionalize the VLP surface at the solvent exposed disulfi de residues to evenly distribute polyethylene glycol (PEG) units to aid in solubilizing the conjugate. [ 42 ] We employed a cysteine rebridging strategy that affords bespoke functionality yet retains the covalent character of the disulfi de bridge. This strategy worked and has potential to become particularly small 2016, 12, No.…”

Section: Introductionmentioning

confidence: 99%

Dual Functionalized Bacteriophage Qβ as a Photocaged Drug Carrier

Chen

et al. 2016

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Proteinatious nanoparticles are emerging as promising materials in biomedical research owing to their many unique properties and our interest focuses on integrating environmental responsivity into these systems. In this work, the use of a virus-like particle (VLP) derived from bacteriophage Qβ as a photocaged drug delivery system is investigated. Ideally, a photocaged nanoparticle platform should be harmless and inert without activation by light yet, upon photoirradiation, should cause cell death. Approximately 530 photocleavable doxorubicin complexes are installed initially onto the surface of Qβ by CuAAC reaction for photocaging therapy; however, aggregation and precipitation are found to cause cell death at higher concentrations. In order to improve solution stability, thiol-dibromomaleimide chemistry has been developed to orthogonally modify the VLP. This chemistry provides a robust method of incorporating additional functionality at the disulfides on Qβ, which was used to increase the stability and solubility of the drug-loaded VLPs. As a result, the dual functionalied VLPs with polyethylene glycol and photocaged doxorubicin show not only negligible cytotoxicity before photoactivation but also highly controllable photorelease and cell killing power.

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Viral chemistry: the chemical functionalization of viral architectures to create new technology

Cited by 55 publications

References 119 publications

Metal–Organic Frameworks for Cell and Virus Biology: A Perspective

Metal–Organic Frameworks for Cell and Virus Biology: A Perspective

Therapeutic Potential of Biomineralization‐Based Engineering

Dual Functionalized Bacteriophage Qβ as a Photocaged Drug Carrier

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