Viomycin

Bowie, J. H.; Cox, D.A.; Johnson, Arthur W.; Thomas, G.

doi:10.1016/0040-4039(64)83088-4

Cited by 13 publications

(1 citation statement)

References 3 publications

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“…Viomycidine, a product of acid hydrolysis of the antibiotic viomycin (21,71,96), was first assigned the structure 3-guanido-A~-pyrroline-2-carboxylic acid (35,36,66,199), believed to arise from a dihydropyrrolopyrimidine unit in the intact antibiotic (35,36). (67) and viomycin (68) have been proposed; viomycidine (2-guanido-A1-pyrroline-5-carboxylic acid) is interpreted as arising from a dihydropyrrolotriazine unit in viomycin (68).…”

Section: Viomycidinementioning

confidence: 99%

Analogs and Homologs of Proline and Hydroxyproline

Mauger¹,

Witkop²

1966

Chem. Rev.

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Section: Viomycidinementioning

confidence: 99%

Analogs and Homologs of Proline and Hydroxyproline

Mauger¹,

Witkop²

1966

Chem. Rev.

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Antibakterielle Naturstoffe in der medizinischen Chemie – Exodus oder Renaissance?

et al. 2006

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Zur Entwicklung von Medikamenten müssen die Strukturvorlagen aus der Natur oft durch Semisynthese oder Totalsynthese verbessert werden (chemische Post‐Evolution). Der Weg vom Naturstoff zum Arzneimittel ist mühsam aber lohnenswert. Die grundlegenden Typen der chemischen Naturstoffmodifikation – Dekoration, Substitution und Abbau – werden hier besprochen, und das biologische, chemische und sozioökonomische Umfeld antibakterieller Forschung wird betrachtet. Naturstoffe waren und bleiben die ergiebigste Leitstrukturquelle für vermarktete Antiinfektiva, und obwohl viele lange bekannte Klassen nie grundlegend erforscht worden sind, erlahmen die industrielle wie die akademische Forschung auf diesem Gebiet – die “altmodischen” Naturstoffe scheinen nicht mehr ins Bild der modernen Wirkstoff‐Forschung zu passen, ihre Handhabung ist aufwändig und erfordert oft nichtstandardisierte Prozesse und längere Bearbeitungszeiten. Eine Neubetrachtung von Naturstoffen mit Methoden der modernen Chemie und Biologie (Reversed Genomics) könnte ihre Renaissance in der Arzneimittelforschung einleiten.

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Antibacterial Natural Products in Medicinal Chemistry—Exodus or Revival?

et al. 2006

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To create a drug, nature's blueprints often have to be improved through semisynthesis or total synthesis (chemical postevolution). Selected contributions from industrial and academic groups highlight the arduous but rewarding path from natural products to drugs. Principle modification types for natural products are discussed herein, such as decoration, substitution, and degradation. The biological, chemical, and socioeconomic environments of antibacterial research are dealt with in context. Natural products, many from soil organisms, have provided the majority of lead structures for marketed anti-infectives. Surprisingly, numerous "old" classes of antibacterial natural products have never been intensively explored by medicinal chemists. Nevertheless, research on antibacterial natural products is flagging. Apparently, the "old fashioned" natural products no longer fit into modern drug discovery. The handling of natural products is cumbersome, requiring nonstandardized workflows and extended timelines. Revisiting natural products with modern chemistry and target-finding tools from biology (reversed genomics) is one option for their revival.

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Viomycin

Cited by 13 publications

References 3 publications

Analogs and Homologs of Proline and Hydroxyproline

Analogs and Homologs of Proline and Hydroxyproline

Antibakterielle Naturstoffe in der medizinischen Chemie – Exodus oder Renaissance?

Antibacterial Natural Products in Medicinal Chemistry—Exodus or Revival?

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