Violaceous plaques on the lower extremities. Cutaneous macroglobulinosis

Brookins-Reddix, Natalie; Spivak, JL; Rm, Watson

doi:10.1001/archderm.124.12.1853

Cited by 4 publications

(3 citation statements)

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“…Deposits of IgM in 4 patients were detected by immunofluorescence. 4,8,9,12 Cryoglobulins and subsequent autoimmune-related manifestations were reported for 1 patient. 16 The presence of isolated IgM deposits in the skin is currently called cutaneous macroglobulin-osis (CM), and a bullous disease form that results from immunoglobulin deposition on the basal membrane has been reported.…”

Section: Commentmentioning

confidence: 99%

“…Specific skin manifestations in patients with WM are rare, and 2 main types are described: neoplastic plasma cell and lymphocyte infiltrates and monoclonal IgM deposits. Sixteen cases of such specific malignant infiltrates have been previously reported [8][9][10][11][12][13][14][15][16][17][18][19][20] (eTable, http: //www.archdermatol.com). The most common lesions were plaques and nodules, which involved the face and the trunk in 9 and 4 patients, respectively, and the in- terval between WM diagnosis and the onset of the skin lesions varied, ranging up to 12 years.…”

Section: Commentmentioning

confidence: 99%

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Cutaneous Macroglobulinosis

Gressier¹,

Hotz²,

Lelievre³

et al. 2010

Arch Dermatol

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Background: Specific cutaneous lesions of Waldenström macroglobulinemia are rare and include neoplastic cell infiltrates, IgM bullous disease, and so-called IgM-storage papules, which characterize cutaneous macroglobulinosis (CM). Observations: We report 2 patients with CM. In patient 1, CM started as small papules, as reported in most of the previously published case studies of CM. In patient 2, lesion evolution was remarkable by its severity, with large ulcerated nodules, and the disease progressed rapidly. As mentioned for half the previously described patients, peripheral neuropathy was suspected in patient 2 and demonstrated in patient 1, with production of antibodies to myelin-associated glycoprotein. Conclusions: To the best of our knowledge, rituximab treatment of Waldenström macroglobulinemia associated with CM has not been described previously. Rituximab caused complete remission of the lesions in patient 1, whereas disease rapidly progressed in patient 2, and the patient died. These observations suggest that evolution of the cutaneous IgM-storage lesions reflects that of the underlying Waldenström macroglobulinemia, and CM is not a prognostic marker.

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Section: Commentmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

Cutaneous Macroglobulinosis

Gressier¹,

Hotz²,

Lelievre³

et al. 2010

Arch Dermatol

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“…Raised levels of circulating IgM monoclonal antibodies lead to their deposition in the skin (cutaneous macroglobulinosis) and other organs. There are only a few isolated case reports of this rare cutaneous presentation of WM 1–4 …”

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confidence: 99%

Keratotic vascular papules over the feet: a case of Waldenström’s macroglobulinaemia-associated cutaneous macroglobulinosis

Harnalikar

Pande

Kharkar

et al. 2010

Clinical and Experimental Dermatology

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Waldenström's macroglobulinaemia (WM) is a plasma-cell dyscrasia characterized by the monoclonal proliferation of lymphoplasmacytes. A 48-year-old man presented with a 4-year history of multiple painful, hyperkeratotic deep-seated papules over the pressure areas of both soles. He had a 1-year history of Raynaud's phenomenon, intermittent epistaxis, recurrent vomiting, tingling and numbness, and visual disturbances. Histological examination of a skin biopsy found amyloid-like deposits in the upper and mid dermis involving dermal blood vessels, but apart from periodic-acid-Schiff, various stains gave negative results for amyloid. Direct immunofluorescence was positive for IgM antibody. Hence, a diagnosis of WM with cutaneous macroglobulinosis was made. Immunoelectrophoresis found monoclonal IgM kappa antibody, and bone-marrow examination revealed a lymphoplasmacytoid malignancy. The patient's systemic systems were attributed to hyperviscosity syndrome associated with WM and the cutaneous papules were identified as deposits of excess IgM antibodies. The patient received five cycles of chemotherapy, resulting in nearly complete resolution of the skin lesions and systemic symptoms.

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Degenerative and metabolic diseases

Brinster¹,

Calonje²

2012

McKee's Pathology of the Skin

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Violaceous plaques on the lower extremities. Cutaneous macroglobulinosis

Cited by 4 publications

References 0 publications

Cutaneous Macroglobulinosis

Cutaneous Macroglobulinosis

Keratotic vascular papules over the feet: a case of Waldenström’s macroglobulinaemia-associated cutaneous macroglobulinosis

Degenerative and metabolic diseases

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