Viola yedoensis Makino alleviates heat stress-induced inflammation, oxidative stress, and cell apoptosis in the spleen and thymus of broilers

Mao, Yan; Kong, Xiangyi; Liang, Zengenni; Yang, Chenglin; Wang, Siqi; Fan, Hui; Ning, Can; Xiao, Wenguang; Wu, You; Wu, Jing; Yuan, Liyun; Yuan, Zhihang

doi:10.1016/j.jep.2023.117350

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…The liver and spleen coe cient can re ect the toxicity of the preparation. The coe cients of liver and spleen increased, indicating organ congestion, edema, and hyperplasia [37,38]. As shown in Fig.…”

Section: In Vivo Biosafety Assessmentmentioning

confidence: 99%

Synergetic treatment of dihydroartemisinin and perillyl alcohol by liposomal nanoplatform for enhanced therapy of cerebral malaria and neurological injury alleviation in C57BL/6J mice

Ren,

Wang,

Jin

et al. 2024

Preprint

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To improve the efficacy of artemisinins against cerebral malaria (CM) in murine, dihydroartemisinin (DHA) and perillyl alcohol (POH) co-loaded liposomes (DP@Tyr-Lips) were designed and prepared, in which POH was expected to exert neuroprotective effects and synergistic therapeutic effects with DHA against CM. Furtherly, tyrosine (Tyr)acted as a substrate of LAT1 transporter could target the brain tissue, was used to modify Lips for improving the accumulation of drugs in the brain via BBB amino acid transporters. DP@Tyr-Lips were prepared with uniform particle size of 91.99 ± 2.67 nm, excellent physical and serum stability, and property of anti-phagocyte phagocytosis. The cumulative release percentages of DHA and POH from DP@Tyr-Lips at 24 h were 66.91 % ± 1.56 % and 58.77 % ± 0.31%, respectively, showing a certain sustained release behavior. Importantly, the inhibition rate of plasmodium of DP@Tyr-Lips was higher than that of DHA-sol. Furthermore, DP@Tyr-Lips could obviously accumulate in the brain and effectively inhibit the occurrence and development of CM, and prolong the survival time of CM mice due to its better biological safety. These findings illustrated that the combination DHA with POH in Tyr modified Lips could achieve the synergistic therapeutic effect and exhibit a significantly enhanced inhibitory effect on the growth of plasmodium, and also improve the neurological injury in a mouse model of CM.

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Section: In Vivo Biosafety Assessmentmentioning

confidence: 99%

Synergetic treatment of dihydroartemisinin and perillyl alcohol by liposomal nanoplatform for enhanced therapy of cerebral malaria and neurological injury alleviation in C57BL/6J mice

Ren,

Wang,

Jin

et al. 2024

Preprint

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Effect of dietary aspirin eugenol ester on the growth performance, antioxidant capacity, intestinal inflammation, and cecal microbiota of broilers under high stocking density

Zhang,

Bai

et al. 2024

Poultry Science

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Chronic Heat Stress Induces Oxidative Stress and Induces Inflammatory Injury in Broiler Spleen via TLRs/MyD88/NF-κB Signaling Pathway in Broilers

Chen,

Wang,

et al. 2024

Veterinary Sciences

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The spleen is the largest peripheral immune organ of the organism, accounting for 25% of the total lymphoid tissue of the body. During HS, the spleen is damaged due to the elevated environment, which seriously affects life performance and broilers’ health. This study aimed to investigate the mechanism of chronic HS damage to broiler spleen tissues. The broilers were typically raised until they reached 21 days of age, after which they were arbitrarily allocated into two groups: an HS group and a cntrol group. The HS group was subjected to a temperature of 35 °C for 10 h each day, starting at 21 days of age. At 35 and 42 days of age, spleen and serum samples were obtained from the broilers. The results showed that after HS, a significant decrease in productive performance was observed at 42 days of age (p < 0.01), and the spleen index, and bursa index were significantly decreased (p < 0.01). T-AOC of the organism was significantly decreased (p < 0.05), GSH-PX, SOD, and CAT antioxidant factors were significantly decreased (p < 0.01), and MDA was significantly elevated (p < 0.01). HS also led to a significant increase in cytokines IL-6, TNF-α, and INF-γ and a significant decrease in IL-4 in the spleen. The histopathologic results showed that the spleen’s red-white medulla was poorly demarcated. The cells were sparsely arranged after HS. After HS, the expression of TLRs, MYD88, and NF-κB genes increased significantly. The expression of HSP70 increased significantly, suggesting that HS may induces an inflammatory response in broiler spleens through this signaling pathway, which may cause pathological damage to broiler spleens, leading to a decrease in immune function and progressively aggravating HS-induced damage with the prolongation of HS.

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Viola yedoensis Makino alleviates heat stress-induced inflammation, oxidative stress, and cell apoptosis in the spleen and thymus of broilers

Cited by 3 publications

References 41 publications

Synergetic treatment of dihydroartemisinin and perillyl alcohol by liposomal nanoplatform for enhanced therapy of cerebral malaria and neurological injury alleviation in C57BL/6J mice

Synergetic treatment of dihydroartemisinin and perillyl alcohol by liposomal nanoplatform for enhanced therapy of cerebral malaria and neurological injury alleviation in C57BL/6J mice

Effect of dietary aspirin eugenol ester on the growth performance, antioxidant capacity, intestinal inflammation, and cecal microbiota of broilers under high stocking density

Chronic Heat Stress Induces Oxidative Stress and Induces Inflammatory Injury in Broiler Spleen via TLRs/MyD88/NF-κB Signaling Pathway in Broilers

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