Vinylimidazole copolymers: coordination chemistry, solubility, and cross-linking as function of Cu2+ and Zn2+ complexation

Andersson, Markus; Hansson, Örjan; Öhrström, Lars; Idström, Alexander; Nydén, Magnus

doi:10.1007/s00396-011-2461-5

Cited by 42 publications

(42 citation statements)

References 48 publications

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“…A reduction in the positive charge on the NP surface as pH increases, as a consequence of the imidazole nitrogen atom deprotonating (Δ ζ H37 = 13.2; Δ ζ H60 = 22.6; Δ ζ H92 = 11.1), can be clearly observed. Consequently the changes in the imidazole ring cause remarkable differences to the NP metal chelating capacities with metal ions occurring in the extracellular matrix such as Zn 2+ and hence can interfere with some metal dependent enzymes such as MMPs, leading to a significance dysfunction in their triggering mechanisms. Consequently the inflammatory responses mediated by the MMP activation could be reduced .…”

Section: Resultsmentioning

confidence: 99%

“…Initial Zn 2+ amount used in the preparation of the complex was adjusted for each polymeric system in order to have a molar ratio of 6:1 (VI:Zn) in all cases. Afterward, the pHs of the suspensions were adjusted over a pH range of 3–7 with HCl or NaOH (0.1 M), and stirred for 2–3 d in order to attain a metal ion adsorption equilibrium . Then, the suspensions were centrifuged (60 min, 12000 rpm, two cycles) to remove the nanoparticles and the supernatant was shaken uncovered for 2–3 d in order to evaporate the organic solvent.…”

Section: Methodsmentioning

confidence: 99%

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Self-Assembling Gradient Copolymers of Vinylimidazol and (Acrylic)ibuprofen With Anti-Inflammatory and Zinc Chelating Properties

et al. 2013

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Novel gradient copolymers of hydrophilic 1-vinylimidazol and hydrophobic methacrylic derivative of ibuprofen prepared by free radical polymerization are described. The heterogeneous distribution of monomeric units along the polymeric chains leads to a gradient distribution of the hydrophobic and hydrophilic sequences responsible of nanoparticles formation through a self-assembling mechanism, capable of tune the water permeation due to the ionizable imidazole moieties and their gradient profile along the macromolecules, exhibiting pH and composition dependent effect in terms of diameter, zeta potential, acid-base buffering, ibuprofen release and chelating capacities, responsible of matrix metalloproteinase dysfunction showing anti-inflammatory activity in a nitric oxide inhibition assay.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Self-Assembling Gradient Copolymers of Vinylimidazol and (Acrylic)ibuprofen With Anti-Inflammatory and Zinc Chelating Properties

et al. 2013

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“…This washing procedure was repeated twice and the material was finally lyophilised, resulting in colourless crystals (4.72 g, 20.1 mmol 78%). 1 The degree of substitution could thus be calculated using Eq. 1.…”

Section: Synthesismentioning

confidence: 99%

“…The addition of a pendant ligand moiety to a polymer backbone is an efficient way of functionalising macromolecular materials providing them with new properties [1][2][3][4][5][6][7] and the imidazole ligand (see Scheme 1) is no exception. The imidazole ligand is of particular interest due to its important role in many biological systems, especially as the side group in histidine which plays an essential role in the active motif of many enzymes [8].…”

Section: Introductionmentioning

confidence: 99%

“…The majority of the these applications and functions exploit the fact that the imidazole group is very strongly and selectively coordinated by metal ions, in particular Cu(II) and Zn(II) [8]. Within our group, this property has been utilised for controlled release of actives by immobilisation of the actives on macromolecules or colloids or by altering the properties of coating materials [1,[17][18][19]. Controlled release is an unexploited application area for coordinated polymers with large potentials.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and polymerisation of maleoyl-L-histidine monomers and addition of histidine to an ethylene-alt-maleic co-polymer

2012

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This work has investigated two routes of synthesising polymers containing L-histidine using maleimide chemistry; grafting of histidine onto an ethylenealt-maleic anhydride copolymer and AIBN (azobisisobutyronitrile) initiated radical polymerisation of the monomer maleoyl-L-histidine. The grafting technique and monomer synthesis are utilising the maleimide formation between the primary amine of histidine and maleic anhydride. The reactions are conveniently carried out in one step with good yields. The copolymers containing L-histidine were prepared by reacting L-histidine or Lhistidine methyl ester with poly(ethylene-alt maleic anhydride) in DMSO at 50°C for 8-16 h with 80% yields independent of the degree of substitution. The monomer maleoyl-L-histidine was synthesised by reacting histidine and maleic anhydride in acetic acid and the monomer was subsequently polymerised by AIBN radical initiation in DMSO at 80°C for 48 h to yield poly(N-histidyl maleimide). The resulting polymer had a different optical rotation ([α] D 20 0−11) than the monomer ([α] D 20 0+25), which is ascribed to the threo-diisotactic and/or threodisyndiotactic stereoregularity of the polymer.

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Fabrication of antifouling membranes by blending poly(vinylidene fluoride) with cationic polyionic liquid

Shen

Zhang

et al. 2019

J of Applied Polymer Sci

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Membrane fouling problem is now limiting the rapid development of membrane technology. A newly synthesized cationic polyionic liquid (PIL) [P(PEGMA-co-BVIm-Br)] was blended with poly(vinylidene fluoride) (PVDF) to prepare antifouling PVDF membranes. The PVDF/P(PEGMA-co-BVIm-Br) exhibited an increased surface hydrophilicity, the water contact angle was reduced from 77.8 (pristine PVDF) to 57.9 . More porous membrane structure was obtained by adding PIL into the blending polymers, as high as 478.0 L/m 2 Áh of pure water flux was detected for the blend PVDF membrane in comparison with pristine PVDF (17.2 L/m 2 Áh). Blending of the cationic PIL with PVDF gave a more positive surface charge than pristine PVDF membrane. Blend membranes showed very high rejection rate (99.1%) and flux recovery rate (FRR, 83.0%) to the positive bovine serum albumin (BSA), due to the electrostatic repulsion between the membrane surface and proteins. After three repeated filtration cycles of positive BSA, the blend PVDF membranes demonstrated excellent antifouling performance, the permeation flux of the membranes was recovered very well after a simple deionized water washing, and as high as 70% of FRR was obtained, the water flux was maintained at above 350 L/m 2 Áh.

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Vinylimidazole copolymers: coordination chemistry, solubility, and cross-linking as function of Cu2+ and Zn2+ complexation

Cited by 42 publications

References 48 publications

Self-Assembling Gradient Copolymers of Vinylimidazol and (Acrylic)ibuprofen With Anti-Inflammatory and Zinc Chelating Properties

Self-Assembling Gradient Copolymers of Vinylimidazol and (Acrylic)ibuprofen With Anti-Inflammatory and Zinc Chelating Properties

Synthesis and polymerisation of maleoyl-L-histidine monomers and addition of histidine to an ethylene-alt-maleic co-polymer

Fabrication of antifouling membranes by blending poly(vinylidene fluoride) with cationic polyionic liquid

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