Vinyl chloride: Dominant lethal studies in male CD-1 mice

Anderson, Diana; Hodge, M.C.E.; Purchase, I. F. H.

doi:10.1016/0165-1218(76)90034-3

Cited by 35 publications

(2 citation statements)

References 11 publications

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“…A fertility study was undertaken prior to the experiment also for reasons described earlier (10,11). From these initial fertility data the background dominant lethality of all groups was determined primarily to ascertain that there were no initial differences between groups.…”

Section: December 1977mentioning

confidence: 99%

Dominant lethal studies with the halogenated olefins vinyl chloride and vinylidene dichloride in male CD-1 mice

Anderson¹,

Hodge²,

Purchase³

1977

Environ Health Perspect

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The mutagenic activity of vinyl chloride (VC) and vinylidene dichloride (VDC) at three exposure levels was assessed in fertile male CD-1 mice with the dominant lethal test. Each compound was assessed in a separate study. Male mice were exposed by inhalation to VC at 3000, 10,000, and 30,000 ppm and to VDC at 10, 30, and 50 ppm for 6 hr/day for 5 days. By comparison with control males exposed to air, no mutagenic effects on any maturation stage of spermatogenesis in treated males were detected. There was no significant increase in the number of postimplantational early fetal deaths as shown by the number of females with one or more early deaths or the number of early deaths/pregnancy or the number of early deaths/total implants/pregnancy. There was no evidence of pre-implantational egg losses as indicated by the total implants/pregnant female. There was also no reduction in fertility. (The reduction in fertility at 50 ppm VDC was unproven). The lack of effect was not due to the insensitivity of the system used, since both the VC and VDC study a mutagenic effect was clearly demonstrated in male mice dosed IP with the positive control compounds cyclophosphamide (CTX) and/or ethylmethane sulfonate (EMS). During dosing these animals were housed under similar exposure conditions to those animals exposed to the test substances but with a flow of air through the exposure chambers. Thus, neither VC nor VDC is mutagenic in the mouse at the stated exposure levels as measured by the dominant lethal test.

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Section: December 1977mentioning

confidence: 99%

Dominant lethal studies with the halogenated olefins vinyl chloride and vinylidene dichloride in male CD-1 mice

Anderson¹,

Hodge²,

Purchase³

1977

Environ Health Perspect

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“…For reasons described earlier (10,11), different evaluation methods were used for the early deaths' data and much of the data in the studies were subjected to various methods of statistical analysis.…”

Section: Early Deathsmentioning

confidence: 99%

Dominant Lethal Studies with the Halogenated Olefins Vinyl Chloride and Vinylidene Dichloride in Male CD-1 Mice

Anderson¹,

Hodge²,

Purchase³

1977

Environmental Health Perspectives

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JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. The National Institute of Environmental Health Sciences (NIEHS) and Brogan & Partners are collaborating with JSTOR to digitize, preserve and extend access to Environmental Health Perspectives. The mutagenic activity of vinyl chloride (VC) and vinylidene dichloride (VDC) at three exposure levels was assessed in ferti}e male CD-1 mice with the dominant lethal test. Each compound was assessed in a separate study.Male mice were exposed by inhalation to YC at 3000 10,000, and 30s00Q ppm and to VDC at 10, 30, and 50 ppm for 6 hr/day for 5 days. By comparison with control males exposed to air, no mutagenic effects on any maturation stage of spermatogenesis in treated males were detected. There was no significant inerease in the number of postimplantational early fetal deaths as shown by the number of females with one or more early deaths or the number of early deathslpregnancy or the number of early deaths/total implants/pregnancy. There was no evidence of pre-implantational egg losses as indicated by the total implants/pregnant female. There was also no reduction in fertility. (The reduction in fertility at 50 ppm VDC was unproven).The lack of effect was not due to the insensitivity of the system used, since both the VC and VDC study a mutagenic effect was clearly demonstrated in male mice dosed IP with the positive control compounds cyclophosphamide (CTX) and/or ethylmethane sultonate (EMS). During dosing these animals were housed under similar exposure conditions to those animals exposed to the test substances but with a flow of air through the exposure chambers.Thus neither VC nor VDC is mutagenic in the mouse at the stated exposure levels as measured by the dominant lethal test. this type in mice after VC and VDC exposure at three levels. At the same time negative control animals exposed to air and positive control animals also exposed to air and given EMS andXor CTX were assayed.

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Unsaturated Halogenated Hydrocarbons

Belpoggi,

Tibaldi,

Gnudi

et al. 2023

Patty's Toxicology

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This chapter contains details on 12 unsaturated halogenated hydrocarbons. The considered chemicals are 1,3‐dichloropropene (DCP), cis ‐ and trans ‐1,2‐dichloroethylene (DCE), dichloroacetylene (DCA), allyl chloride (AC), hexachlorobutadiene (HCBD), β‐chloropropene, vinylidene chloride (VDC), vinyl chloride (VC), vinyl bromide (VB), vinyl fluoride (VF), trichloroethene (TCE), and tetrachloroethene (PCE). These compounds are used as fumigants, pesticides, solvents, and chemical intermediates. This chapter follows the outline determined for compounds and includes physical and chemical properties, production and use, exposure assessment in air and workplace, toxic effects (experimental and epidemiological studies), community methods for monitoring, regulations, and guidelines.

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Vinyl chloride: Dominant lethal studies in male CD-1 mice

Cited by 35 publications

References 11 publications

Dominant lethal studies with the halogenated olefins vinyl chloride and vinylidene dichloride in male CD-1 mice

Dominant lethal studies with the halogenated olefins vinyl chloride and vinylidene dichloride in male CD-1 mice

Dominant Lethal Studies with the Halogenated Olefins Vinyl Chloride and Vinylidene Dichloride in Male CD-1 Mice

Unsaturated Halogenated Hydrocarbons

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