Vinpocetine Release From a Microencapsulated Form

Polkovnikova, Yu. A.; Сливкин, А. И.

doi:10.1007/s11094-016-1488-9

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…Vascular diseases of the brain continue to be a thorny medical-and-social problem in contemporary society (Bertram & Tanzi, 2005;Polkovnikova & Slivkin, 2015). Pharmacological correction of the cerebral blood flow is an actual problem of modern medicine since in the basis of a lot of cerebral diseases there are factors of vascular genesis while the diseases themselves are accompanied by a loss of working ability, disability and mortality (Haress, 2015).…”

Section: Introductionmentioning

confidence: 99%

Development of Cinnarizine Liposome Technology

Polkovnikova

2022

jour

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Introduction. Liposomal preparations have a number of advantages: they protect the cells of the body from the toxic effects of drugs; prolong the action of the drug introduced into the body; protect medicinal substances from degradation; contribute to the manifestation of targeted specificity due to selective penetration from the blood into tissues; change the pharmacokinetics of drugs, increasing their pharmacological efficacy; allow you to create a water-soluble form of a number of medicinal substances, thereby increasing their bioavailability.In this work, studies were carried out to develop a methodology for determining the degree of inclusion in liposomes from soy lecithin of cinnarizine, which has found wide application as a corrector of cerebral circulation disorders.Purpose. The purpose of the study is to determine the amount of adsorption of cinnarizine with liposomes from soy lecithin.Materials and methods. Cinnarizine liposomes from soy lecithin were prepared by the hydration/rehydration method. To study the characteristics of the degree of incorporation of cinnarizine into liposomes, the method of equilibrium dialysis was used. The choice of this method is due to the fact that the quantitative analysis of the equilibrium concentration of cinnarizine in the dispersion medium, which is necessary to determine the amount of adsorption, is hampered by the presence of a dispersed phase, liposomes. A semipermeable membrane with a pore diameter sufficient for the penetration of cinnarizine molecules, but impermeable to liposomes, makes it possible to obtain a cinnarizine solution with a concentration close enough to the concentration in the dispersion medium of liposomes. The solution thus obtained can be subjected to quantitative analysis using spectrophotometry.Results. A graph of the dependence of the value of adsorption of cinnarizine on liposomes on the equilibrium concentration was plotted. It was found that the value of adsorption of cinnarizine during the treatment of liposomes with ultrasound is less for all the studied concentrations. At an equilibrium concentration of cinnarizine of more than 0.0003 mol/l, the proportion of the prearat associated with liposomes stabilizes. Without sonication at the level of 24.83 ± 1.15%, with sonication at the level of 18.4 ± 1.20%.Conclusion. It has been established that ultrasonic treatment of liposomes is expedient when cinnarizine is added to a dry lipid film, since it is a factor that increases bioavailability

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Section: Introductionmentioning

confidence: 99%

Development of Cinnarizine Liposome Technology

Polkovnikova

2022

jour

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“…A promising drug for the designed a microencapsulated form is Vinpocetine [6,7]. Vinpocetine is poorly water soluble.…”

Section: Introductionmentioning

confidence: 99%

Quantum-chemical calculation free energy of vinpocetine molecule release from sodium alginate

Polkovnikova¹,

Korynova²,

Halahakoon³

2018

jrp

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ABSTRACT:Microencapsulation is a method of obtaining traditional materials in a unique form that is able to protect substances from the effects of environmental factors that cause their decomposition. This method is used in medicine and pharmacy, where drugs and enzymes are encapsulated in biodegradable microcapsules. The aim of the study was a possibility of the use of sodium alginate for microencapsulation of vinpocetine on the basis of comparative analysis of thermodynamic characteristics concerned with the efficiency of vinpocetine release from sodium alginate into water and ethanol. The following methods of investigations were applied: The molecular modeling of the process of vinpocetine release from the microcapsules into various media was carried out for: water with pH value 2.0, 7.0, and ethyl alcohol 95%. The molecular dynamics method in the Bioevrik program was implemented to the modeling "polymer-vinpocetine" systems in the aqueous and ethanol environments. Results of the study: It was found that vinpocetine release is mostly energy-efficient into aqueous medium with рН=2, as compared with aqueous medium at рН= 7 and 95% ethyl alcohol.

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