Vinorelbine Is an Effective and Safe Drug for AIDS-Related Kaposi’s Sarcoma: Results of a Phase II Study

Nasti, Guglielmo; Errante, D.; Talamini, Renato; Rizzardini, Giuliano; Fasan, Marco; Landonio, G; Zeroli, Claudia; Chichino, Guido; Nigra, Ezio; Vaccher, Emanuela; Tirelli, Umberto

doi:10.1200/jco.2000.18.7.1550

Cited by 53 publications

(20 citation statements)

References 20 publications

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“…Unfortunately, in the majority of the published series on adult angiosarcoma, the use of chemotherapy with the drugs usually administered for soft tissue sarcoma did not significantly improve the outcome [10]. Some reports, nonetheless, pointed to a potential effect of chemotherapy using aggressive chemoterapeutic regimens [16] or different single-agent schedules with vinorelbine [17,18] or methotrexate [19]: in the review by Silverman et al on breast angiosarcoma a significant advantage in diseasefree survival was reported for patients treated with chemotherapy (29.2% vs. 4%) [19]. The report from Fata et al from the Memorial Sloan-Kettering Cancer Center seems particularly relevant, where paclitaxel was shown to be effective as a single agent against cutaneous angiosarcoma of the scalp and face, even in previously-treated patients [20].…”

Section: Discussionmentioning

confidence: 98%

Malignant vascular tumors in children and adolescents: A report from the Italian and German soft tissue sarcoma cooperative group

Ferrari

Casanova

Bisogno

et al. 2002

Med. Pediatr. Oncol.

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Angiosarcoma and related malignant vascular tumors are aggressive neoplasms with a poor prognosis; their behavior in children seems no different from their adult counterparts. Complete surgical resection remains the mainstay of treatment, but is probably sufficient in only a minority of cases. Postoperative radiotherapy may have a role and could be added to improve local control. The role of chemotherapy is uncertain, but the high rate of metastatic spread prompts investigation into new chemotherapeutic approaches.

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Section: Discussionmentioning

confidence: 98%

Malignant vascular tumors in children and adolescents: A report from the Italian and German soft tissue sarcoma cooperative group

Ferrari

Casanova

Bisogno

et al. 2002

Med. Pediatr. Oncol.

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“…[30][31][32] Other drugs that have proven useful include Paclitaxel 33 and vinorelbine. 34 However, all these newer agents are expensive and would not be considered for inclusion in an essential drugs list for oncology in the resourcestrapped environments of sub-Saharan Africa.…”

Section: Discussionmentioning

confidence: 99%

Treatment of AIDS-associated Kaposi's sarcoma in Zimbabwe: Results of a randomized quality of life focused clinical trial

Olweny¹,

Borok

Gudza

et al. 2004

Int. J. Cancer

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Kaposi's sarcoma is currently the most common tumor in Zimbabwe. The purpose of our study is to compare the effectiveness of supportive care vs. 3 intervention approaches, namely oral Etoposide, a 3-drug combination, and radiotherapy using quality of life (QOL) as the primary measure of success. In addition, our study was to determine whether a disease-specific module has greater sensitivity to group differences than a generic QOL questionnaire and to determine the most pragmatic approach to treating epidemic Kaposi's sarcoma (EKS) in Zimbabwe. In addition, on the physical and psychological subscales, the Etoposide group had a significantly better QOL than the other 3 treatment groups (p < 0.04). The 3-drug combination, supportive care and radiotherapy groups did not differ significantly from each other with respect to the total FLI-C score or its subscales. There were no group differences with respect to survival. Oral Etoposide therapy resulted in better total FLI-C QOL score than radiotherapy. As well, Etoposide resulted in better physical and psychological subscale scores than radiotherapy, 3-drugs and supportive care. Thus, funds permitting, oral Etoposide is a pragmatic approach to treating EKS in an environment where antiretroviral drugs are not universally available. The study underscores the value of undertaking studies in areas of disease prevalence and the necessity of selecting appropriate outcome measures.

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“…Paclitaxel is a safe and effective alternative monotherapy, with response rates that range from 59% to 71%. 227,228 Other agents used alone or in combination include vinca alkaloids, 229,230 bleomycin, [231][232][233] and granulocyte-macrophage colony-stimulating factor. 234,235 Multiple prospective, randomized trials have shown superior response rates and an improved toxicity profile of liposomal anthracyclines in comparison with vincristine or bleomycin, or their combination.…”

Section: Treatmentmentioning

confidence: 99%

Cutaneous malignancy and human immunodeficiency virus disease

Wilkins

Turner

Dolev

et al. 2006

Journal of the American Academy of Dermatology

129

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Vinorelbine Is an Effective and Safe Drug for AIDS-Related Kaposi’s Sarcoma: Results of a Phase II Study

Abstract: Vinorelbine is safe and effective in the treatment of patients with advanced KS who have been previously treated with one or more chemotherapy regimens.

Cited by 53 publications

References 20 publications

Malignant vascular tumors in children and adolescents: A report from the Italian and German soft tissue sarcoma cooperative group

Malignant vascular tumors in children and adolescents: A report from the Italian and German soft tissue sarcoma cooperative group

Treatment of AIDS-associated Kaposi's sarcoma in Zimbabwe: Results of a randomized quality of life focused clinical trial

Cutaneous malignancy and human immunodeficiency virus disease

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