2003
DOI: 10.1177/030089160308900106 View full text |Buy / Rent full text
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Abstract: The schedule is able to control the evolution of hormone-refractory prostate cancer and to give a clinical benefit. These results provide information for further clinical trials in a large series of elderly cancer patients.

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“…It is a mitotic inhibitor with better therapeutic index and lower neurotoxicity with respect to other vinca alkaloids, due to the lower axonal degradation associated with its use. Use of vinorelbine in the treatment of prostate cancer, although limited, has been shown to be effective: several studies 7 , 8 , 28 , 29 previously showed clinical response rate and pain control. Specifically, clinical response was reported to range between 20–40% with 20% reduction of PSA levels.…”
Section: Discussionmentioning
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“…It is a mitotic inhibitor with better therapeutic index and lower neurotoxicity with respect to other vinca alkaloids, due to the lower axonal degradation associated with its use. Use of vinorelbine in the treatment of prostate cancer, although limited, has been shown to be effective: several studies 7 , 8 , 28 , 29 previously showed clinical response rate and pain control. Specifically, clinical response was reported to range between 20–40% with 20% reduction of PSA levels.…”
Section: Discussionmentioning
“…Specifically, clinical response was reported to range between 20–40% with 20% reduction of PSA levels. 7 , 8 , 28 , 29 …”
Section: Discussionmentioning
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“…Please use proper citation format when citing this article including the DOI, publisher reference, volume number and page location. mustine and docetaxel (11)(12)(13)(14). These observations DOX was diluted in 500 cc of a saline solution and administered by IV infusion over 2 h, followed by an prompted us to consider three aspects of the problem.…”
Section: Introductionmentioning
“…It preferentially binds to the mitotic spindle and affects microtubules in neural structures to a lesser degree than the parental compound and, thus, it is associated with less neurotoxicity [1,2,3]. Vinorelbine is active against a broad range of solid tumors [4,5,6]. The oral formulation of vinorelbine is particularly interesting because it is rapidly absorbed, has an elimination half-life of 40 h, is highly bound to platelets, has a hepatic metabolism and an absolute bioavailability of 40%, being similar to that of the parental drug [7].…”
Section: Introductionmentioning