Vinegar consumption can attenuate postprandial glucose and insulin responses; a systematic review and meta-analysis of clinical trials

Shishehbor, Farideh; Mansoori, Anahita; Shirani, Fatemeh

doi:10.1016/j.diabres.2017.01.021

Cited by 45 publications

(28 citation statements)

References 39 publications

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“…16,19 A recent metaanalysis that comprised of data from individuals with and without diabetes also showed reduced postprandial blood glucose. 40 Regression analysis of PPI levels corroborated the aforementioned finding by showing higher levels of insulin in the vinegar group at 30 minutes but lower values at subsequent time points. The delayed response in the secretion of the insulin could be due to the delay in the absorption of the glucose through the gut due to the action of vinegar as suggested by various studies.…”

Section: Discussionsupporting

confidence: 68%

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Diabetes Control: Is Vinegar a Promising Candidate to Help Achieve Targets?

Siddiqui

Assam

Souza

et al. 2018

J Evid Based Complementary Altern Med

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Background.Renewed interest in vinegar as a glucose-lowering agent led to several small trials in the recent past. However, none of the trials could independently provide sufficient evidence.Objectives.Our review aimed to obtain reliable estimates of effects of vinegar on short-term and long-term blood glucose control.Methods.Large bibliographic databases were searched from inception to date of search without language and publication date restrictions. All clinical trials evaluating effect of vinegar on diabetes mellitus patients were eligible. Two authors independently extracted data on fasting and 2-hour postprandial blood glucose, insulin, and HbA1c levels at the various time points. MS Excel, SAS® v9.3, and RevMan v5.3 were used for data analysis.Results.Small significant reduction in mean HbA1c was observed after 8 to 12 weeks of vinegar administration: −0.39% (95% confidence interval = −0.59, −0.18; I 2 = 0%). Other long-term outcomes favored vinegar but were not significant. Short-term outcomes showed significantly lower pooled mean difference in glucose levels at 30 minutes in the vinegar group. Readings at 60, 90, and 120 minutes were lower in the vinegar group but not statistically significant. Adverse effects profile also favored the vinegar group.Conclusions.It is worthwhile to carry out carefully planned large trails to determine the efficacy and effectiveness of vinegar as an adjunct treatment modality.

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Section: Discussionsupporting

confidence: 68%

“… 16 , 19 A recent meta-analysis that comprised of data from individuals with and without diabetes also showed reduced postprandial blood glucose. 40 …”

Section: Discussionmentioning

confidence: 99%

Diabetes Control: Is Vinegar a Promising Candidate to Help Achieve Targets?

Siddiqui

Assam

Souza

et al. 2018

J Evid Based Complementary Altern Med

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“…The suppression of glucose production from carbohydrates in the gut or glucose absorption from the intestine has been previously investigated using vinegar resources ( Johnston and Gaas, 2006 ; Shishehbor et al, 2017 ; Santos et al, 2019 ). As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Vinegars contain several bioactive compounds that are characterized according to the type of raw materials, such as grain vinegars and fruit vinegars ( Xia et al, 2020 ). In the past 20 years, there have been several reports in which intake of vinegar with a meal was shown to reduce postprandial glucose concentrations in clinical trials featuring healthy adults and patients with diabetes ( Johnston and Gaas, 2006 ; Shishehbor et al, 2017 ; Santos et al, 2019 ). This therapeutic effect of vinegars might be due to the presence of bioactive components including organic acids, amino acids, and polyphenolics, capable of maintaining glucose homeostasis ( Xia et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Inhibitory Effects of Organic Acids Identified in Commercial Vinegars on α-Amylase and α-Glucosidase

Noh

Lee

et al. 2020

pnf

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The aim of this work was to evaluate the inhibitory activities of organic acids identified from commercial vinegars on α-amylase and α-glucosidase. Six organic acids (acetic, citric, lactic, malic, succinic, and tartaric) were identified in nine commercial vinegars, whose contents varied considerably depending on the raw materials. Most of the fruit vinegars, comprised of various organic acids, were found to be more effective inhibitors against digestive enzymes than grain vinegars containing mainly acetic acid. Citric acid had the lowest IC 50 values for α-amylase and α-glucosidase activities 0.64±0.04 μM/mL and 8.95±0.05 μM/mL, respectively, and thus exhibited the strongest antidiabetic effect. Mulberry fruit vinegar containing the highest content of total organic acid (111.02±1.50 mg/mL) showed the strongest digestive enzyme inhibitory impact. The results indicate that vinegars with higher contents of various organic acids hold strong potential against digestive enzymes.

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“…Here in Malaysia, the combination of these natural products is among the widely-marketed food supplements for treating diabetesrelated symptoms as well as maintenance of general health. While these natural products may have been shown to have anti-hyperglycemic properties individually (Bayan et al 2014;Erejuwa et al 2012;Farideh et al 2017;Sharma et al 2015;Shidfar et al 2015), there is little to no evidence to ExPErIMENTAL TrIALS Figure 1 showed the general overview of the experimental protocol. All test days started in the morning with a standardised test meal, followed by a 2-hour observation in the postprandial period.…”

Section: Introductionmentioning

confidence: 99%

Acute Modulatory Effects of Apple Cider Vinegar, Garlic, Ginger, Lemon and Honey Mixture, with and Without Exercise on Postprandial Glycemia in Non-Diabetic Females

Ishak

George

Ibrahim

et al. 2018

JSKM

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Postprandial hyperglycemia is independently related to cardiovascular disease. Garlic, ginger, lemon, honey and apple cider vinegar are known to have anti-glycemic properties. However, the effectiveness of combination of these natural products on reducing postprandial glycemia is uncertain. The aim of the present study was to investigate the glucoselowering effect of a novel mixture consisting of apple cider vinegar, garlic, ginger, lemon, and honey; alone and in combination with exercise in response to a high-carbohydrate meal in non-diabetic individuals. Ten, female subjects (mean age: 25 ± 2.67 years, mean BMI: 22.6 ± 3.5 kg/m 2) participated in this randomised, cross-over intervention consisting of four trials: control (CON), mixture only (MIX), exercise only (EX), and exercise + mixture (EX-MIX). All trials involved consumption of a high-carbohydrate breakfast, then followed by rest in CON, consumption of natural product mixture in MIX, brisk-walking exercise in EX, and combination of mixture and exercise in EX-MIX. Blood glucose was measured at fasting, and at 30, 60, 90, 120 minutes post meal. Postprandial glucose response was calculated as area under the glucose curve. Two-way repeated measures ANOVA showed a significant group and time interaction (p < 0.001). Compared to CON, postprandial glucose responses were 8%, 13% and 15% lower in MIX (p = 0.049), EX (p = 0.001) and EX-MIX (p = 0.005) respectively. Postprandial glucose was 8% lower in EX-MIX compared to MIX (p = 0.002). In conclusion, consuming natural product mixture containing garlic, ginger, lemon, honey and apple cider vinegar reduced postprandial glycemia to a certain extent, however, combining mixture with exercise produced a greater attenuation effect compared to consuming mixture alone. This finding is indicative of a potential benefit of the novel mixture as a complementary management of hyperglycemia in high-risk individuals.

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Vinegar consumption can attenuate postprandial glucose and insulin responses; a systematic review and meta-analysis of clinical trials

Cited by 45 publications

References 39 publications

Diabetes Control: Is Vinegar a Promising Candidate to Help Achieve Targets?

Diabetes Control: Is Vinegar a Promising Candidate to Help Achieve Targets?

In Vitro Inhibitory Effects of Organic Acids Identified in Commercial Vinegars on α-Amylase and α-Glucosidase

Acute Modulatory Effects of Apple Cider Vinegar, Garlic, Ginger, Lemon and Honey Mixture, with and Without Exercise on Postprandial Glycemia in Non-Diabetic Females

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