Vine pollen allergy in areas with a high density of vineyards

Brito, Francisco Feo; Gimeno, Pilar Mur; Bartolomé, B; Alonso, Ana; Lara, Pilar; Fernández, José Antonio López; Martı́nez, Alberto

doi:10.1016/s1081-1206(10)60054-3

Cited by 8 publications

(13 citation statements)

References 15 publications

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“…Interesting results have also been collected in oncological conditions; Vitis vinifera has shown some efficacy in reducing radiotherapy-induced dermatitis [164] and in inhibiting cell proliferation in melanoma [165, 166] and skin non-melanoma cancer [167], indicating grape seed proanthocyanidin as an apoptosis and autophagy inducer. Rare allergic reactions are reported for Vitis vinifera [168].…”

Section: Phytochemicals In Skin Diseasesmentioning

confidence: 99%

Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases

Forni

Facchiano

Bartoli

et al. 2019

BioMed Research International

364

219

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Aging is related to a number of functional and morphological changes leading to progressive decline of the biological functions of an organism. Reactive Oxygen Species (ROS), released by several endogenous and exogenous processes, may cause important oxidative damage to DNA, proteins, and lipids, leading to important cellular dysfunctions. The imbalance between ROS production and antioxidant defenses brings to oxidative stress conditions and, related to accumulation of ROS, aging-associated diseases. The purpose of this review is to provide an overview of the most relevant data reported in literature on the natural compounds, mainly phytochemicals, with antioxidant activity and their potential protective effects on age-related diseases such as metabolic syndrome, diabetes, cardiovascular disease, cancer, neurodegenerative disease, and chronic inflammation, and possibly lower side effects, when compared to other drugs.

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Section: Phytochemicals In Skin Diseasesmentioning

confidence: 99%

Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases

Forni

Facchiano

Bartoli

et al. 2019

BioMed Research International

364

219

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“…Members of the thaumatin-like protein family are described as important allergens in peaches, too (Palacín et al, 2010) and they were described to be allergens in other fruit: cherry, apple, banana, kiwi, or olive and in pollens, too. This family is supposed to belonging to panallergens that are responsible for pollen-fruit crossreactivity (Breiteneder, 2004).…”

Section: Resultsmentioning

confidence: 99%

Expression pattern of thaumatin in the selected red varieties of Vitis vinifera, L.

Žiarovská

Fialková

Zamiešková

et al. 2019

Potr. S. J. F. Sci.

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Vitis vinifera L. is a specie that is adapted to a very variable range of climates, from cold up to the desert one, but especially it grows in the temperate Mediterranean regions and continental areas of Europe. Grape is a widespread consumed fruit as well as processed to musts, juices or wine. The health beneficial effects of grapes and wine are very well known due to their high nutritional value and unique phytochemical composition. Despite many health protective and beneficial effects of Vitis vinifera, a part of population suffer to allergic reactions to this fruit. Allergens of wine and grapes are: endochitinases, lipid-transfer protein and thaumatin. Thaumatin is a protein having a sweet taste belonging to the PR5-like proteins. These proteins are very difersified in their functions and were described to be involved in stress responses and fruit ripening, but are expressed in healthy grape fruits in a constitutive manner and needn´t to be expressed only as a answer to the stress. Thaumatin is a minor allergen in grape, but belonging to the suspected panallergens relevant to the food cross-allergy induction, its importance is quite high. Another importance of this protein is a technological one, as reported to aggregate in wine to form a visible haze unless removed prior to bottling. In this study, expression of thaumatin-like allergen was analysed in the grapes of selected varieties. Grapes of four red varieties of Vitis vinifera, L. were obtained in the season 2017 in the Sabo winery that belongs to the Malokarpatská wine region. Fresh maturated grapes of varieties Alibernet, Cabernet Sauvignon , Frankovka modrá and Dornfelder were analysed. Expression changes of thaumatin was calculated by delta delta Ct method. Dornfelder was found as to have the lowest activity in thaumatin-like gene activity, mainly when comparing to the Cabernet Sauvignon and Frankovka modrá. Alibernet, on the other side, has the expression level of thaumatin very similar when comparing to the Cabernet Sauvignon and Frankovka modrá.

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“…Conjunctival allergen provocation test is known as the only way to confirm the conjunctival specific response to a clinically suspected allergen, in SAC and, particularly, in PAC . It may also confirm the diagnosis when an unusual allergen is suspected . In a specific paper focused on conjunctivitis due to mite allergy, Bertel et al included 30 patients affected by PAC and sensitized to mites, 21 patients also affected by ocular allergy but without mite sensitization and nine asymptomatic patients.…”

Section: Indications and Contraindications Of The Captmentioning

confidence: 99%

Conjunctival allergen provocation test : guidelines for daily practice

Fauquert

Jędrzejczak-Czechowicz

Rondón

et al. 2016

Allergy

102

142

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Conjunctival allergen provocation test (CAPT) reproduces the events occurring by instilling an allergen on the ocular surface. This paper is the compilation of a task force focussed on practical aspects of this technique based on the analysis of 131 papers. Main mechanisms involved are reviewed. Indications are diagnosing the allergen(s)-triggering symptoms in IgE-mediated ocular allergy in seasonal, acute or perennial forms of allergic conjunctivitis, especially when the relevance of the allergen is not obvious or in polysensitized patients. Contraindications are limited to ongoing systemic severe pathology, asthma and eye diseases. CAPT should be delayed if receiving systemic steroids or antihistamines. Local treatment should be interrupted according to the half-life of each drug. Prerequisites are as follows: obtaining informed consent; evidencing of an allergen by skin prick tests and/or serum-specific IgE dosages; being able to deal with an unlikely event such as acute asthma exacerbation, urticaria or anaphylaxis, or an exacerbation of allergic conjunctivitis. Allergen extracts should be diluted locally prior to administration. Positive criteria are based on itching or quoted according to a composite score. An alternative scoring is based on itching. CAPT remains underused in daily practice, although it is a safe and simple procedure which can provide valuable clinical information.The conjunctival allergen provocation test (CAPT), also known as conjunctival allergen challenge (CAC), is a conjunctival provocation test (CPT) used to evaluate the inflammatory effects on the external ocular surface after the topical application of an allergen in a presumed sensitized patient. The aim was to objectively evaluate the reactivity to specific allergens at the mucosal surface (1).As stated in a recent Position Paper on Ocular Allergy, CAPT is a method for investigating the ocular surface IgE-mediated hypersensitivity disorders. It is used to determine or confirm which allergen(s) triggers the ocular symptoms, using the eye as a model to evidence a specific reactivity to allergen(s) (2). Conjunctival allergen provocation test is also a tool for investigating allergic inflammation mechanisms and biomarkers of the ocular surface, as well as its treatments. Recently, it has been used as a surrogate test of mucosal reactivity in other allergic diseases, namely rhinitis, asthma, food and latex allergy (3-5).Allergy 72 (2017) 43-54

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Vine pollen allergy in areas with a high density of vineyards

Cited by 8 publications

References 15 publications

Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases

Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases

Expression pattern of thaumatin in the selected red varieties of Vitis vinifera, L.

Conjunctival allergen provocation test : guidelines for daily practice

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