Vincristine-induced vocal cord paresis and paralysis in children

Vocal cord paralysis secondary to vincristine treatment in children -- A case series of seven children and literature review

“…In all seven cases, and similarly to the other cases we identified in the literature, symptoms occurred often during the induction period within a few doses of vincristine 1,4,5 , thus suggesting toxicity may not necessarily be dose dependant.…”

“…To date there are around twenty case reports and a few small case series of no more than three paediatric patients 4 . Symptom onset mostly occurred during the induction phase of treatment 4 .…”

“…To date there are around twenty case reports and a few small case series of no more than three paediatric patients 4 . Symptom onset mostly occurred during the induction phase of treatment 4 . Similarly in the other cases that were identified symptoms resolved after cessation of vincristine which had variable rates of recovery from weeks to months.…”

Vocal Fold Motion Impairment Following Chemotherapy Administration: Case Reports and Review of the Literature

“…CIVFMI secondary to vinblastine (n = 2, 5.7%), paclitaxel (n = 2, 5.7%) and cisplatin (n = 1, 2.9%) has also been reported. It is important to note that many chemotherapeutic agents were not used as monotherapy but rather as part of an established multiagent protocol, such as the RCHOP protocol for ALL consisting of vincristine, rituximab, cyclophosphamide, Harris et al 13 Moderate Naithani et al 14 High Praveen et al 15 High Taha et al 16 Moderate Kumar et al 17 High Rezvani et al 18 Moderate Whittaker et al 19 High Choi et al 20 High Aghajan et al 21 Moderate Rahmat et al 22 High Kuruvilla et al 11 Moderate Aaron et al 23 High Patra et al 24 High Ahmed et al 25 High Samoon et al 26 High Latiff et al 27 High Bacon et al 28 High Anghelescu et al 29 Moderate Zavala et al 30 High Yalin et al 31 High Burns et al 32 Moderate Farruggia et al 33 High Cherif et al 34 High Total 25 0 25 0 25 0 16 9 25 0…”

Vocal cord paralysis secondary to vincristine treatment in children: A case series of seven children and literature review

“…Recurrent laryngeal nerve palsy resulting in vocal cord paralysis (vcp) in children has been documented in the literature in multiple case reports and small number of case series 4 . We present the largest case series to date of seven children who sustained vcp secondary to vincristine chemotherapy for ALL and review the literature.…”