Vincristine and ivermectin combination chemotherapy in dogs with natural transmissible venereal tumor of different cyto-morphological patterns: A prospective outcome evaluation

Bulhosa, Laiane Ferreira; Estrela‐Lima, Alessandra; Solcà, Manuela da Silva; Gonçalves, Gabriel Saraiva Diniz; Larangeira, Daniela Farias; Pinho, Flaviane Alves de; Barrouin‐Melo, Stella Maria

doi:10.1016/j.anireprosci.2020.106358

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…Ivermectin is administered subcutaneously at a dose of 0.5 mg/kg body weight. (11). Additionally, radiotherapy and immunotherapy using autovaccine or serum from dogs that have undergone spontaneous remission have been successfully used, as well as surgical removal of the tumor with a margin of healthy tissue if possible, especially in the case of small tumors.…”

Section: Tumors Of the Vagina And Vulvamentioning

confidence: 99%

Tumors of the reproductive system of bitches - based on the description of selected own clinical cases and literature data

BRODZKI¹,

WOLNIACZYK²,

GŁODKOWSKA³

et al. 2023

Medycyna Weterynaryjna

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Tumors of the reproductive system in bitches can affect any of its anatomical structures. The predominant lesions are those appearing in the vagina and vulva, accounting for about 2.4-3% of all tumors in bitches, followed by ovarian tumors – 0.5-1.2%, while uterine tumors are rare and it is difficult to even estimate their incidence. The most common type of ovarian tumor is granulosa cell tumor (GCT), which originates from the granulosa cells of the Graff follicle. In the uterus, vagina and vulva, the most common is smooth-cell myoma (leiomyoma), along with its malignant types (leiomyosarcoma, rhabdomyosarcoma), derived from mesenchymal tissue. Diagnosis of these lesions is mainly based on a detailed clinical examination, vaginoscopy, imaging tests (ultrasound, X-ray, CT) and evaluation of sex hormone levels. However, accurate differentiation of tumors is possible only by histopathological examination. The most effective method of treatment is the surgical removal of diagnosed tumors. The paper presents our own clinical cases of tumors of different parts of the reproductive system in bitches: ovarian tumors (GCT); uterine tumors (leyomyoma); and tumors of the vagina and vulva (fibromyoma, leyomyoma). Moreover, the numerous illustrations included in the paper, documenting the mentioned cases, are a valuable addition to the publication.

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Section: Tumors Of the Vagina And Vulvamentioning

confidence: 99%

Tumors of the reproductive system of bitches - based on the description of selected own clinical cases and literature data

BRODZKI¹,

WOLNIACZYK²,

GŁODKOWSKA³

et al. 2023

Medycyna Weterynaryjna

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In vitro screening of novel anti-Babesia gibsoni drugs from natural products

Liu

Galon

et al. 2021

Parasitology International

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Surgical Management of Canine Transmissible Venereal Tumor with Adjunctive Chemotherapy Combination

Avazi,

Alo-Aleje,

Tanko

et al. 2024

RVSM

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One male and a female 2-year-old Neapolitan Mastiff dogs weighing 41 and 40 kg, respectively, were presented to the University Veterinary Teaching Hospital, Jos, Nigeria, with complaints of continuous bleeding from the prepuce and vulva which were first observed about 2 months before presentation. Clinical examination revealed preputial bleeding of the male dog and serosanguinous vulva discharges with the presence of palpable masses with multiple nodules that were cauliflower-like. Cytological evaluations of smears from preputial and vaginal swabs revealed characteristic round cells with large eccentric nuclei, large nuclear-cytoplasmic ratio, and intracytoplasmic vacuolations as well as anisocytosis and anisokaryosis. Based on these cytological features, a diagnosis of canine transmissible venereal tumor (CTVT) was made in each case. Blood samples were collected for hematology and clinical chemistry. Debulking of the masses was carried out under general anesthesia using atropine sulfate and chlorpromazine as pre-anesthetics and Ketamine hydrochloride as induction and maintenance anesthetics. Following debulking, the resulting defect was reconstructed and the surgical wound was managed by daily wound cleaning and the administration of vincristine sulfate (0.025 mg/kg) slowly intravenously, ivermectin (0.3 mg/kg) subcutaneously, and piroxicam (0.3 mg/kg) and 20% amoxicillin (20 mg/kg) intramuscularly. There were no observed known vincristine sulfate-associated adverse effects as the dogs recovered and were discharged 3-week post-tumor debulking with no recurrence within 6 months of follow-up examinations. The debulked mass histologically showed several sheets of round neoplastic cells with prominent nuclei, mitotic figures, and infiltrating lymphocytes. Based on these findings, a diagnosis of CTVT was further confirmed. The hemogram showed moderate leukocytosis at day 1 in the bitch with a mild left shift at days 1 and 14 while clinical chemistry showed a marked increase in alkaline phosphatase, moderate increase in serum creatinine, and mild hypoproteinemia. In conclusion, management of CTVT with adjunctive vincristine sulfate and ivermectin combination resulted in complete healing with amelioration of known associated adverse effects.

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Vincristine and ivermectin combination chemotherapy in dogs with natural transmissible venereal tumor of different cyto-morphological patterns: A prospective outcome evaluation

Cited by 3 publications

References 38 publications

Tumors of the reproductive system of bitches - based on the description of selected own clinical cases and literature data

Tumors of the reproductive system of bitches - based on the description of selected own clinical cases and literature data

In vitro screening of novel anti-Babesia gibsoni drugs from natural products

Surgical Management of Canine Transmissible Venereal Tumor with Adjunctive Chemotherapy Combination

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