Vinclozolin-induced mouse penile malformation and “small testis” via miR132, miR195a together with the Hippo signaling pathway

Yu, Haiming; Yang, Jinru; Zhang, Yujing; Fu, Haidong; Yan, Zhengli; Zhu, Yongfei

doi:10.1016/j.tox.2021.152842

Cited by 7 publications

(4 citation statements)

References 55 publications

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“…In addition to these restrictions inside the United States, as of 2006, the use of this pesticide was restricted in numerous nations, including Denmark, Finland, Norway, and Sweden. To assess its risks and hazards to the environment and animals, a number of tests and regulations have been applied [ 3 , 4 ]. Vinclozolin is created as extruded or dried flowable granules.…”

Section: Introductionmentioning

confidence: 99%

Chronic Exposure to Endocrine Disruptor Vinclozolin Leads to Lung Damage via Nrf2–Nf-kb Pathway Alterations

D’Amico

Paola

Impellizzeri

et al. 2022

IJMS

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Endocrine-disrupting substances (EDS) are common and pervasive in our environment and pose a serious risk to both human and animal health. Endocrine-disrupting compounds (EDCs) have been associated with a variety of detrimental human health effects, including respiratory issues, as a result of their ability to disrupt cell physiology. Vinclozolin ((RS)-3-(3,5-Dichlorophenyl)-5-methyl-5-vinyloxazolidine-2,4-dione) is a common dicarboximide fungicide used to treat plant diseases. Several studies have analyzed the effects of vinclozolin exposure on the reproductive system, but less is known about its effect on other organs such as the lung. Mice were exposed for 28 days to orally administered vinclozolin at a dose of 100 mg/kg. Vinclozolin exposure induced histological alterations and collagen depositions in the lung. Additionally, vinclozolin induced inflammation and oxidative stress that led to lung apoptosis. Our study demonstrates for the first time that the toxicological effects of vinclozolin are not limited to the reproductive system but also involve other organs such as the lung.

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Section: Introductionmentioning

confidence: 99%

Chronic Exposure to Endocrine Disruptor Vinclozolin Leads to Lung Damage via Nrf2–Nf-kb Pathway Alterations

D’Amico

Paola

Impellizzeri

et al. 2022

IJMS

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“…Specific genes were discovered and involved in hypospadias formation in rats and mice (261)(262)(263)(264). Prenatal atrazine and vinclozolin exposure can affect penile and testicular development (265).…”

Section: Animal Modelsmentioning

confidence: 99%

Current perspectives in hypospadias research: A scoping review of articles published in 2021 (Review)

Gozar¹,

Bara²,

Dicu³

et al. 2023

Exp Ther Med

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Hundreds of papers are written about hypospadias every year referring to all aspects of the pathology, being one of the most common congenital malformations. The present study conducted a scoping review of articles published in 2021 to present the main issues and summarize current perspectives and achievements in the field. It searched for the keyword 'hypospadias' in the three most popular databases (PubMed, Scopus and Web of Science). After the analysis of the publications, they were categorized into different domains.

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“…The Hippo signalling pathway is a highly conserved pathway among different organisms, as well as in different tissues and organs in an individual organism, and regulates a variety of biological functions of malignant tumours, including proliferation and apoptosis. Hippo signalling plays a critical role in the pathogenesis and development of tumours 3 . Moreover, the Hippo signalling pathway is involved in the regulation of cell proliferation and apoptosis, control of organ size, and maintenance of the internal tissue environment.…”

Section: Introductionmentioning

confidence: 99%

ZNF143 facilitates the growth and migration of glioma cells by regulating KPNA2-mediated Hippo signalling

Chen

et al. 2023

Sci Rep

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The disordered expression of ZNF143 is closely related to the malignant progression of tumours. However, the basic control mechanism of ZNF143 in glioma has not yet been clarified. Therefore, we tried to find a new pathway to illustrate the function of ZNF143 in glioma. To explore the function of KPNA2 in the development of glioma, we used survival analysis by the Kaplan‒Meier method to assess the overall survival (OS) of patients with low and high KPNA2 expression in the TCGA and CGGA cohorts. Western blotting assays and RT‒PCR assays were utilized to determine the expression level of KPNA2 in glioma cells. The interaction between ZNF143 and KPNA2 was confirmed by ChIP assays. Proliferation was assessed by CCK-8 assays, and migration was evaluated by wound healing and Transwell assays. Apoptosis was determined by flow cytometry, and the expression level of YAP/TAZ was visualized using an immunofluorescence assay. The expression levels of LATS1, LATS2, YAP1, and p-YAP1 were determined. Patients with low KPNA2 expression showed a better prognosis than those with high KPNA2 expression. KPNA2 was found to be upregulated in human glioma cells. ZNF143 can bind to the promoter region of KPNA2. Downregulation of ZNF143 and KPNA2 can activate the Hippo signalling pathway and reduce YAP/TAZ expression in human glioma cells, thus inducing apoptosis of human glioma cells and weakening their proliferation, migration and invasion. In conclusion, ZNF143 mediates the Hippo/YAP signalling pathway and inhibits the growth and migration of glioma cells by regulating KPNA2.

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Vinclozolin-induced mouse penile malformation and “small testis” via miR132, miR195a together with the Hippo signaling pathway

Cited by 7 publications

References 55 publications

Chronic Exposure to Endocrine Disruptor Vinclozolin Leads to Lung Damage via Nrf2–Nf-kb Pathway Alterations

Chronic Exposure to Endocrine Disruptor Vinclozolin Leads to Lung Damage via Nrf2–Nf-kb Pathway Alterations

Current perspectives in hypospadias research: A scoping review of articles published in 2021 (Review)

ZNF143 facilitates the growth and migration of glioma cells by regulating KPNA2-mediated Hippo signalling

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