Vincamine as an agonist of G protein-coupled receptor 40 effectively ameliorates pulmonary fibrosis in mice

Zhao, Tong; Zhou, Zhiruo; Zhao, Suping; Wan, Hui-Qi; Li, Honglin; Hou, Jiwei; Wang, Jiaying; Qian, Minyi; Shen, Xu

doi:10.1016/j.phymed.2023.154919

Cited by 4 publications

(2 citation statements)

References 47 publications

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“…In the context of IL-13, the results of the VCN-treated animals were supported by a previously published work investigating the anti-inflammatory effect of 10mg/kg of vinpocetine in a model of allergic asthma in mice 30 . In the context of altering the lung tissue expression of NF-κB and the inflammasome NLRP3, the results of the present work regarding the induced (BLM) group and the VCN-treated group were supported by a recently published study on the ameliorating effect of vincamine in pulmonary fibrosis in mice 67 .…”

Section: Discussionsupporting

confidence: 74%

Vinpocetine alleviated alveolar epithelial cells injury in experimental pulmonary fibrosis by targeting PPAR-γ/NLRP3/NF-κB and TGF-β1/Smad2/3 pathways

Hussein,

Abu-Raghif,

Tahseen

et al. 2024

Sci Rep

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This study aimed to investigate the potential anti-fibrotic activity of vinpocetine in an experimental model of pulmonary fibrosis by bleomycin and in the MRC-5 cell line. Pulmonary fibrosis was induced in BALB/c mice by oropharyngeal aspiration of a single dose of bleomycin (5 mg/kg). The remaining induced animals received a daily dose of pirfenidone (as a standard anti-fibrotic drug) (300 mg/kg/PO) and vinpocetine (20 mg/kg/PO) on day 7 of the induction till the end of the experiment (day 21). The results of the experiment revealed that vinpocetine managed to alleviate the fibrotic endpoints by statistically improving (P ≤ 0.05) the weight index, histopathological score, reduced expression of fibrotic-related proteins in immune-stained lung sections, as well as fibrotic markers measured in serum samples. It also alleviated tissue levels of oxidative stress and inflammatory and pro-fibrotic mediators significantly elevated in bleomycin-only induced animals (P ≤ 0.05). Vinpocetine managed to express a remarkable attenuating effect in pulmonary fibrosis both in vivo and in vitro either directly by interfering with the classical TGF-β1/Smad2/3 signaling pathway or indirectly by upregulating the expression of Nrf2 enhancing the antioxidant system, activating PPAR-γ and downregulating the NLRP3/NF-κB pathway making it a candidate for further clinical investigation in cases of pulmonary fibrosis.

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Section: Discussionsupporting

confidence: 74%

Vinpocetine alleviated alveolar epithelial cells injury in experimental pulmonary fibrosis by targeting PPAR-γ/NLRP3/NF-κB and TGF-β1/Smad2/3 pathways

Hussein,

Abu-Raghif,

Tahseen

et al. 2024

Sci Rep

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show abstract

“…Vincamine, a monoterpene indole alkaloid extracted from Madagascar periwinkle (Apocynaceae), is clinically used to treat cerebrovascular diseases by increasing cerebral blood flow and oxygen consumption to improve cognitive dysfunction (Zhao et al. 2023 ). Researchers have hypothesized that vincamine could potentially aid in the treatment of DPN in mice.…”

Section: Methodsmentioning

confidence: 99%

Advances of traditional Chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathy

Zhang,

Wu,

Yao

et al. 2024

Pharmaceutical Biology

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Aloe emodin promotes mucosal healing by modifying the differentiation fate of enteroendocrine cells via regulating cellular free fatty acid sensitivity

Bao,

Lyu,

Feng

et al. 2024

Acta Pharmaceutica Sinica B

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Vincamine as an agonist of G protein-coupled receptor 40 effectively ameliorates pulmonary fibrosis in mice

Cited by 4 publications

References 47 publications

Vinpocetine alleviated alveolar epithelial cells injury in experimental pulmonary fibrosis by targeting PPAR-γ/NLRP3/NF-κB and TGF-β1/Smad2/3 pathways

Vinpocetine alleviated alveolar epithelial cells injury in experimental pulmonary fibrosis by targeting PPAR-γ/NLRP3/NF-κB and TGF-β1/Smad2/3 pathways

Advances of traditional Chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathy

Aloe emodin promotes mucosal healing by modifying the differentiation fate of enteroendocrine cells via regulating cellular free fatty acid sensitivity

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