Vinca alkaloids as a potential cancer therapeutics: recent update and future challenges

Banyal, Aditya; Tiwari, Shubham; Sharma, Aparajita; Chanana, Ishita; Patel, Sanjay; Kulshrestha, Saurabh; Kumar, Pradeep

doi:10.1007/s13205-023-03636-6

Cited by 14 publications

(4 citation statements)

References 112 publications

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“…[8] However, acquiring these chemicals naturally was inefficient and had a low production rate. [9] Research has been made to seek improvements in the production of vinca alkaloids and various methods have been used. Sidkey's research showed that it is possible to increase the production of secondary metabolites of Catharanthus roseus by increasing the growth factor and thus increasing the yield of needed vinca alkaloids.…”

Section: Descriptionmentioning

confidence: 99%

A review of several anticancer chemicals derived from natural medicinal plant

Dong

2024

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Humans have used natural plants and plant-derived medicines to cure various diseases for thousands of years. Of all the diseases that humans are facing, cancer is one of the most destructive ones. Scientists have studied anticancer chemicals from natural plants for decades, and some chemicals show significant effects against cancer and are applied widely in clinical use. Vinca alkaloids are a type of chemical derived from Catharanthus roseus. Members of the vinca alkaloids have been used in many chemotherapy regimens. Taxol is one of the most famous plant-derived medicines against cancer. Scientists have focused more than twenty years on improving its synthesis route. Solanine comes from plants in the genus Solanum. This kind of plant is used in TCM for cancer treatment. Apart from these land plants, marine plants and marine photosynthetic algae are also sources of antitumor agents. Carrageenan and Fucoidan are two examples of antitumor-active compounds derived from seagrass. They have both cytotoxicity and adjuvant ability. In the future, there will be more research on the improvement of the synthetic route of existing herbal compounds, the discovery of new herbal compounds, and the better utilization and combination of herbal compounds, and finally lead to better application of natural plant medicine against cancer.

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Section: Descriptionmentioning

confidence: 99%

A review of several anticancer chemicals derived from natural medicinal plant

Dong

2024

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“…The first type of alkaloid that was applied in cancer therapy was discovered in the 1950s accidentally from Vinca rosea, a plant that is also referred to as Catharanthus roseus, by two researchers; namely, Charles Beer and Robert Noble [ 16 ]. Knowledge of the traditional use of this plant in reducing blood glucose led them to investigate its hypoglycemic effect in rats.…”

Section: Alkaloids In Cancer Treatment: a Historical Perspectivementioning

confidence: 99%

Therapeutic Role of Alkaloids and Alkaloid Derivatives in Cancer Management

2023

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Cancer is a neoplastic disease that remains a global challenge with a reported prevalence that is increasing annually. Though existing drugs can be applied as single or combined therapies for managing this pathology, their concomitant adverse effects in human applications have led to the need to continually screen natural products for effective and alternative anticancer bioactive principles. Alkaloids are chemical molecules that, due to their structural diversity, constitute a reserve for the discovery of lead compounds with interesting pharmacological activities. Several in vitro studies and a few in vivo findings have documented various cytotoxic and antiproliferative properties of alkaloids. This review describes chaetocochin J, neopapillarine, coclaurine, reflexin A, 3,10-dibromofascaplysin and neferine, which belong to different alkaloid classes with antineoplastic properties and have been identified recently from plants. Despite their low solubility and bioavailability, plant-derived alkaloids have viable prospects as sources of viable lead antitumor agents. This potential can be achieved if more research on these chemical compounds is directed toward investigating ways of improving their delivery in an active form close to target cells, preferably with no effect on neighboring normal tissues.

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“…Derived from various sources such as plants, marine organisms, fungi, and microorganisms, natural compounds have inspired the development of synthetic analogs with improved pharmacological properties [16]. For example, the discovery of vinca alkaloids from the periwinkle plant led to the development of semisynthetic analogs like vinblastine and vincristine, which are used in cancer chemotherapy [17].…”

Section: Introductionmentioning

confidence: 99%

Exploring CDKN1A Upregulation Mechanisms: Insights into Cell Cycle Arrest Induced by NC2603 Curcumin Analog in MCF-7 Breast Cancer Cells

Nishimura,

Sampaio,

Komoto

et al. 2024

IJMS

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Breast cancer stands out as one of the most prevalent malignancies worldwide, necessitating a nuanced understanding of its molecular underpinnings for effective treatment. Hormone receptors in breast cancer cells substantially influence treatment strategies, dictating therapeutic approaches in clinical settings, serving as a guide for drug development, and aiming to enhance treatment specificity and efficacy. Natural compounds, such as curcumin, offer a diverse array of chemical structures with promising therapeutic potential. Despite curcumin’s benefits, challenges like poor solubility and rapid metabolism have spurred the exploration of analogs. Here, we evaluated the efficacy of the curcumin analog NC2603 to induce cell cycle arrest in MCF-7 breast cancer cells and explored its molecular mechanisms. Our findings reveal potent inhibition of cell viability (IC50 = 5.6 μM) and greater specificity than doxorubicin toward MCF-7 vs. non-cancer HaCaT cells. Transcriptome analysis identified 12,055 modulated genes, most notably upregulation of GADD45A and downregulation of ESR1, implicating CDKN1A-mediated regulation of proliferation and cell cycle genes. We hypothesize that the curcumin analog by inducing GADD45A expression and repressing ESR1, triggers the expression of CDKN1A, which in turn downregulates the expression of many important genes of proliferation and the cell cycle. These insights advance our understanding of curcumin analogs’ therapeutic potential, highlighting not just their role in treatment, but also the molecular pathways involved in their activity toward breast cancer cells.

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Vinca alkaloids as a potential cancer therapeutics: recent update and future challenges

Cited by 14 publications

References 112 publications

A review of several anticancer chemicals derived from natural medicinal plant

A review of several anticancer chemicals derived from natural medicinal plant

Therapeutic Role of Alkaloids and Alkaloid Derivatives in Cancer Management

Exploring CDKN1A Upregulation Mechanisms: Insights into Cell Cycle Arrest Induced by NC2603 Curcumin Analog in MCF-7 Breast Cancer Cells

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