Vinblastine‐Induced Erythrocytotoxicity

Neville, Alan J.; Rand, Carol A.; Barr, Ronald D.

doi:10.1111/j.1600-0609.1982.tb02117.x

Cited by 6 publications

(5 citation statements)

References 22 publications

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“…A similar profile was observed with Bleo, in contrast to VBL which produced no significant effect. The latter finding confirms the earlier results reported by Neville et al (17). combination of all 3 cytotoxic agents was associated with the greatest alteration in red cell shape.…”

Section: Discussionsupporting

confidence: 92%

“…suspension was added to each tube so that the final concentration of each drug was equal to its peak therapeutic concentration in vivo ( Table 2). After incubation at 37°C for 1 h in a water bath, 45 pI aliquots were fixed and examined by the glutaraldehyde-glycerol technique as described by Neville et al (17). 100 cells were counted per slide using the criteria of Bessis (18) and Zipursky et al (19).…”

Section: Abbreviationsmentioning

confidence: 99%

“…stomatocyte, 1-11 cell (transition phase between discocyte and stomatocyte) and hemisphere; and 'non-disc, non-bowl'. This is a modified form of the classification used by Neville et al (17). Due to the wide variation in the relative proportions of discocytes and bowls in normal subjects, each subject acted as his own control.…”

Section: Abbreviationsmentioning

confidence: 99%

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The Effects of Cisplatin on Normal Human Erythrocytes in Vitro

Dawson

Brown

Barr

1983

Scandinavian Journal of Haematology

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Therapeutic administration of cisplatin is often followed by anaemia which may not be due entirely or even largely to myelosuppression but rather to drug‐induced haemolysis. Similar experience with other cytotoxic agents prompted earlier investigations which yielded evidence of drug‐induced changes in RBC shape in vitro. Current studies of cisplatin and bleomycin, which have been used together in clinical practice, revealed a significant alteration in the profile of RBC morphology; specifically a reduction in the number of ‘bowl’ shaped cells. However, this finding is in contrast to the increase in ‘bowls’ which was observed previously with other drugs. So it appears that direct erythrocytotoxicity cannot explain the occurrence of anaemia in patients who receive cisplatin. An alternative mechanism, similar to that of penicillin induced haemolysis, is suggested by immunoradiometric assays of surface IgG on red cells.

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Section: Discussionsupporting

confidence: 92%

Section: Abbreviationsmentioning

confidence: 99%

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The Effects of Cisplatin on Normal Human Erythrocytes in Vitro

Dawson

Brown

Barr

1983

Scandinavian Journal of Haematology

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“…From the parameters in Tables and , it is also possible to provide an estimate for the value of the nondimensional number

\overset{normal Π}{true}

in Equation . Using the highest value for σ , we find

\overset{normal Π}{true} = \frac{L_{p} L μ σ R T C_{r}}{C d^{3}} ≃ 0.05 \frac{ℓ}{mol} \times C_{r} .

Since a realistic value for the reference concentration of the drugs that we considered is given by C r ≃1÷10 × 10 − 6 mol/ ℓ , we obtain the estimate

\overset{normal Π}{true} ≃ 5 \div 50 \times 1 0^{- 8}

. We can thus simplify the expression for the fluid flux in Equation , which now reads

{\overset{normal Φ}{true}}_{b} = {\overset{L}{true}}_{p} ((), p_{n} - p_{t}),

{\overset{normal Φ}{true}}_{d} = ((), 1 - σ) \overset{c}{true} {\overset{normal Φ}{true}}_{b} + \overset{normal Υ}{true} ((), c_{n} - c_{t}),

where we have also reported the updated expression for the drug flux.…”

Section: Microscale and Macroscale Computational Setupsmentioning

confidence: 94%

“…Since a realistic value for the reference concentration of the drugs that we considered is given by C r 1 ÷ 10 × 10 −6 mol/ [35,36], we obtain the estimateΠ 5 ÷ 50 × 10 −8 . We can thus simplify the expression for the fluid flux in Equation (10), which now reads:…”

Section: Physiological Parametersmentioning

confidence: 99%

The role of the microvascular network structure on diffusion and consumption of anticancer drugs

Mascheroni

Penta

2017

Numer Methods Biomed Eng

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SUMMARYWe investigate the impact of the tumor microvascular geometry on transport of drugs in solid tumors, in particular focusing on the diffusion and consumption phenomena. We embrace recent advances in the asymptotic homogenization literature starting from a double Darcy, double advection-diffusion-reaction system of partial differential equations which is obtained exploiting the sharp length separation between the intercapillary distance and the average tumor size. The geometric information on the microvascular network is encoded into effective hydraulic conductivities and diffusivities, which are numerically computed by solving periodic cell problems on appropriate microscale representative cells. The coefficients are then injected into the macroscale equations, which are solved for an isolated, vascularized spherical tumor. We consider the effect of vascular tortuosity on the transport of anti-cancer molecules, focusing on the Vinblastine and Doxorubicin dynamics, which can be considered a tracer and a highly interacting molecule, respectively. The computational model is able to quantify the performance of the treatment through the analysis of the interstitial drug concentration and the quantity of drug metabolized in the tumor. Our results show that both drug advection and diffusion are dramatically impaired by increasing geometrical complexity of the microvasculature, leading to non-optimal absorption and delivery of therapeutic agents. However, this effect apparently has a minor role whenever the dynamics are mostly driven by metabolic reactions in the tumor interstitium, i.e. for highly interacting molecules. In the latter case, anti-cancer therapies that aim at regularizing the microvasculature might not play a major role and different strategies are to be developed.

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Chemotherapeutic agents and the erythron

Doll

Weiss

1983

Cancer Treatment Reviews

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Vinblastine‐Induced Erythrocytotoxicity

Cited by 6 publications

References 22 publications

The Effects of Cisplatin on Normal Human Erythrocytes in Vitro

The Effects of Cisplatin on Normal Human Erythrocytes in Vitro

The role of the microvascular network structure on diffusion and consumption of anticancer drugs

Chemotherapeutic agents and the erythron

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