Vimentin expression in circulating tumor cells (CTCs) associated with liver metastases predicts poor progression-free survival in patients with advanced lung cancer

Wang, Ying; Liu, Yanxia; Zhang, Lina; Li, Tong; Gao, Yuan; Hu, Feng; Lin, Peter Ping; Li, Baolan; Zhang, Tongmei

doi:10.1007/s00432-019-03040-9

Cited by 43 publications

(38 citation statements)

References 31 publications

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“…EpCAM + aneuploid rare cells in peripheral blood and BM significantly correlated with systemic metastasis in breast cancer patients [ 82 ]. Moreover, Vimentin + lung cancer rare cells at baseline were relevant to hepatic metastasis [ 145 ]. Furthermore, postsurgical small EpCAM + multiploid rare cells in circulation were found to correlate with HCC patients’ postoperative recurrence [ 83 ].…”

Section: Clinical Significance and The Novel Therapeutic Target Pomentioning

confidence: 99%

Aneuploid Circulating Tumor-Derived Endothelial Cell (CTEC): A Novel Versatile Player in Tumor Neovascularization and Cancer Metastasis

Lin

2020

Cells

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Hematogenous and lymphogenous cancer metastases are significantly impacted by tumor neovascularization, which predominantly consists of blood vessel-relevant angiogenesis, vasculogenesis, vasculogenic mimicry, and lymphatic vessel-related lymphangiogenesis. Among the endothelial cells that make up the lining of tumor vasculature, a majority of them are tumor-derived endothelial cells (TECs), exhibiting cytogenetic abnormalities of aneuploid chromosomes. Aneuploid TECs are generated from “cancerization of stromal endothelial cells” and “endothelialization of carcinoma cells” in the hypoxic tumor microenvironment. Both processes crucially engage the hypoxia-triggered epithelial-to-mesenchymal transition (EMT) and endothelial-to-mesenchymal transition (EndoMT). Compared to the cancerization process, endothelialization of cancer cells, which comprises the fusion of tumor cells with endothelial cells and transdifferentiation of cancer cells into TECs, is the dominant pathway. Tumor-derived endothelial cells, possessing the dual properties of cancerous malignancy and endothelial vascularization ability, are thus the endothelialized cancer cells. Circulating tumor-derived endothelial cells (CTECs) are TECs shed into the peripheral circulation. Aneuploid CD31+ CTECs, together with their counterpart CD31- circulating tumor cells (CTCs), constitute a unique pair of cellular circulating tumor biomarkers. This review discusses a proposed cascaded framework that focuses on the origins of TECs and CTECs in the hypoxic tumor microenvironment and their clinical implications for tumorigenesis, neovascularization, disease progression, and cancer metastasis. Aneuploid CTECs, harboring hybridized properties of malignancy, vascularization and motility, may serve as a unique target for developing a novel metastasis blockade cancer therapy.

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Section: Clinical Significance and The Novel Therapeutic Target Pomentioning

confidence: 99%

Aneuploid Circulating Tumor-Derived Endothelial Cell (CTEC): A Novel Versatile Player in Tumor Neovascularization and Cancer Metastasis

Lin

2020

Cells

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“…Circulating tumour cells (CTCs) analysis has recently emerged as a liquid biopsy approach for the early diagnosis [1,2], biomarker [3], evaluation of curative efficacy [4], evaluation of relapse [5] and prognostic prediction [6,7] in several solid tumours, including breast cancer [8,9],gastric cancer [10], prostate cancer [11], head and neck cancer [12], bladder cancer [13], and lung cancer [14][15][16]. CTCs also showed the potential efficacy in metastasis cancer, such as metastatic breast cancer [17,18] and colorectal cancer [19].…”

Section: Introductionmentioning

confidence: 99%

The combination of CTCs and CEA can help guide the management of patients with SPNs suspected of being lung cancer

et al. 2020

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Objective: Solitary pulmonary nodules (SPNs) is a common radiographic finding and require further evaluation because of the possibility of lung cancer. This study aimed to determine the sensitivity and specificity of circulating tumour cells (CTCs) as a marker for the diagnosis of SPNs and the integration of CTCs, carcinoembryonic antigen (CEA) and imaging findings to improve the sensitivity and specificity of diagnosis in patients with SPNs suspected of being lung cancer. Method: For the serum biomarker assay, the concentration of CEA was measured by an automated electrochemiluminescence analyzer. CTCs were collected from 6 ml of blood by the SE i-FISH method, which detects the gene copy number in eight chromosomes and the tumour-associated antigen CK18. Results: With a threshold of 6 CTC units, the method showed a sensitivity of 67.1% and a specificity of 56.5% in the diagnosis of NSCLC, especially in the upper lobe, in which the diagnostic strength was the highest (P < 0.01). CTCs, CEA and nodule type had the highest diagnostic efficacy (area under the curve, 0.827; 95% confidence interval, 0.752-0.901) in patients with SPNs being suspected lung cancer. Combining CTCs (cut-off value 12 units) with CEA (1.78 ng/ml), the method showed a sensitivity of 77.8% and a specificity of 90% in the diagnosis of NSCLC, especially in the upper lobe, subsolid nodules and nodules ≥8 mm. Conclusions: Our results demonstrated that CTCs are feasible diagnostic biomarkers in patients with SPNs, especially in the upper lobe. Furthermore, CTCs combined with CEA showed higher diagnostic efficacy in the upper lobe, subsolid nodules and nodules ≥8 mm.

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“…Circulating tumour cells (CTCs) analysis has recently emerged as a liquid biopsy approach for the early diagnosis [1,2] , biomarker [3] , evaluation of curative efficacy [4] , evaluation of relapse [5] and prognostic prediction [6,7] in several solid tumours, including breast cancer [8,9] ,gastric cancer [10] , prostate cancer [11] , head and neck cancer [12] , bladder cancer [13] , and lung cancer [14][15][16] . CTCs also showed the potential efficacy in metastasis cancer, such as metastatic breast cancer [17,18] and colorectal cancer [19] .…”

Section: Introductionmentioning

confidence: 99%

The combination of CTCs and CEA can help guide the management of patients with SPNs suspected of being lung cancer

Zheng

Zhao

et al. 2019

Preprint

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Objective: Solitary pulmonary nodules (SPNs) is a common radiographic finding and require further evaluation because of the possibility of lung cancer. This study aimed to determine the sensitivity and specificity of circulating tumour cells (CTCs) as a marker for the diagnosis of SPNs and the integration of CTCs, carcinoembryonic antigen (CEA) and imaging findings to improve the sensitivity and specificity of diagnosis in patients with SPNs suspected of being lung cancer.Method: For the serum biomarker assay, the concentration of CEA was measured by an automated electrochemiluminescence analyzer. CTCs were collected from 6 ml of blood by i-FISH method, which detects the gene copy number in eight chromosomes and the tumour-associated antigen CK18.Results: With a threshold of 6 CTC units, the method showed a sensitivity of 67.1% and a specificity of 56.5% in the diagnosis of NSCLC, especially in the upper lobe, in which the diagnostic strength was the highest (P < 0.01). CTCs, CEA and nodule type had the highest diagnostic efficacy (area under the curve, 0.827; 95% confidence interval, 0.752-0.901) in patients with SPNs being suspected lung cancer. Combining CTCs (cut-off value 12 units) with CEA (1.78 ng/ml), the method showed a sensitivity of 77.8% and a specificity of 90% in the diagnosis of NSCLC, especially in the upper lobe, sub solid nodules and nodules ≥8 mm.Conclusion: Our results demonstrated that CTCs are feasible diagnostic biomarkers in patients with SPNs, especially in the upper lobe. Furthermore, CTCs combined with CEA showed higher diagnostic efficacy in the upper lobe, sub solid nodules and nodules ≥8 mm.

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Vimentin expression in circulating tumor cells (CTCs) associated with liver metastases predicts poor progression-free survival in patients with advanced lung cancer

Cited by 43 publications

References 31 publications

Aneuploid Circulating Tumor-Derived Endothelial Cell (CTEC): A Novel Versatile Player in Tumor Neovascularization and Cancer Metastasis

Aneuploid Circulating Tumor-Derived Endothelial Cell (CTEC): A Novel Versatile Player in Tumor Neovascularization and Cancer Metastasis

The combination of CTCs and CEA can help guide the management of patients with SPNs suspected of being lung cancer

The combination of CTCs and CEA can help guide the management of patients with SPNs suspected of being lung cancer

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