VIM-AS1, regulated by CpG methylation, cooperates with IGF2BP1 to inhibit tumor aggressiveness via EPHA3 degradation in hepatocellular carcinoma
Su-hyang Han,
Je Yeong Ko,
Sungju Jung
et al.
Abstract:Background
Early tumor recurrence observed in hepatocellular carcinoma (HCC) remains challenging, as the mechanisms involved have not been completely elucidated. Microvascular invasion is associated with early recurrence; however, well-established biomarkers for diagnosis and predicting prognosis are lacking. In this study, we aimed to identify DNA methylation sites predicting liver cancer patient prognosis and validate HCC aggressiveness molecular mechanisms.
Methods
DNA methylome data from HCC patient sample… Show more
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