Vilsmeier Haack Acetylation in Micellar Media: An Efficient One Pot Synthesis of 2‐Chloro‐3‐acetyl Quinolines

Rajanna, K. C.; Ali, M. M.; Sana, Sariah; Tasneem,; Saiprakash, P. K.

doi:10.1081/dis-120027663

Cited by 18 publications

(5 citation statements)

References 25 publications

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“…It is very well known that V-H reagent will produce aryl formats from phenols. In continuation of our ongoing work on V-H reactions under various modified conditions we have reported a certain V-H reaction in micellar media [21] and under ultrasonic conditions [22].…”

Section: Introductionmentioning

confidence: 73%

Transition Metal Ions as Efficient Catalysts for Facile Ortho-Formylation of Phenols under Vilsmeier–Haack Conditions

Aneesa¹,

Rajanna

Kumar³

et al. 2012

Organic Chemistry International

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Aromatic compounds (phenols), when treated with Vilsmeier Haack (V-H) reagent in the presence of transition metal ions such as Cu(II), Ni(II), Co(II), Cd(II), and Zn(II) under reflux conditions, afforded corresponding ortho-formyl derivatives in good yields. Under normal conditions the metal-ion-free V-H reactions are too sluggish and resulted in poor yields. This protocol provides highly regioselective formylation under a mild and efficient condition with simple workup.

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Section: Introductionmentioning

confidence: 73%

Transition Metal Ions as Efficient Catalysts for Facile Ortho-Formylation of Phenols under Vilsmeier–Haack Conditions

Aneesa¹,

Rajanna

Kumar³

et al. 2012

Organic Chemistry International

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“…Researchers have already thoroughly investigated and recorded a wide range of "Microwave assisted" responses [6][7][8][9][10] . However, the solvents or catalysts utilized so far for those "Microwave assisted reactions,"such as Pd(II) 11 , FeCl 3 12 , CaCl 2 13 , and ZnI 2 14 , are hazardous, unfavorable to the environment, and toxic to human health.…”

Section: Introductionmentioning

confidence: 99%

Amla Fruit Extract: Green and Natural Catalyst for the Synthesis of Acylated Derivatives via Microwave Technique

Begum,

Mohammed,

Begum

et al. 2024

Orient. J. Chem

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The current work demonstrates Amla fruit extract efficiency as a promising green catalyst for microwave assisted acylation processes. This is an attempt to recreate the ancient acylation procedures that used metal catalysts. The results obtained for the synthesis of naphthalene-2-yl-acetate, N-(2-nitrophenyl)acetamide, N-phenylacetamide, 1-phenylpropane-1,2-dione, acetic benzoic anhydride, N-acetylbenzamide, phenyl acetate (A1-A7) in the presence of amla juice as a green catalyst were exemplary which determines that the efficacy of the natural amla juice extract proved to be an excellent alternative catalyst. These reactions will represent a significant breakthrough in chemical synthesis, particularly in the acylation of organic molecules with potential biological activity.

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“…A special attention has also been focused on conducting the reactions under solvent free conditions by grinding the reactants in a mortar with a pestle or by microwave irradiation to achieve greenery conditions [8]. For the past few decades our group has also been actively engaged in exploiting the use of the above cited tools to assist various organic transformations such as Vilsmeier-Haack, Hunsdiecker [9][10][11], and nitration reactions [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Polyethylene Glycol Mediated Kinetic Study of Nitro Decarboxylation of α,β‐Unsaturated Acids by Blau’s Fe(III) Phen Complex

Ramesh

Shylaja

Rajanna

et al. 2013

Journal of Chemistry

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Polyethylene glycol (PEG) mediated kinetic study of nitro decarboxylation of , -unsaturated acids (USA) has been taken up by Blau's [Fe(III) nitrate-Phen] yellow complex in acetonitrile medium. Kinetics of the reactions indicated Michaelis-Menton type of mechanism and rate law. Reaction rates are significantly influenced by the structural variation and concentration of PEG. Catalysis of PEG was explained on the lines of nonionic micelles such as TX-100 because of their structural resemblance and also due to a slight negative charge developed on polyoxyethylene and cationic form(s) of Fe(III) chelates in the intermediate stages.

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Vilsmeier Haack Acetylation in Micellar Media: An Efficient One Pot Synthesis of 2‐Chloro‐3‐acetyl Quinolines

Cited by 18 publications

References 25 publications

Transition Metal Ions as Efficient Catalysts for Facile Ortho-Formylation of Phenols under Vilsmeier–Haack Conditions

Transition Metal Ions as Efficient Catalysts for Facile Ortho-Formylation of Phenols under Vilsmeier–Haack Conditions

Amla Fruit Extract: Green and Natural Catalyst for the Synthesis of Acylated Derivatives via Microwave Technique

Polyethylene Glycol Mediated Kinetic Study of Nitro Decarboxylation of α,β‐Unsaturated Acids by Blau’s Fe(III) Phen Complex

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