Vilsmeier formylation and glyoxylation reactions of nucleophilic aromatic compounds using pyrophosphoryl chloride

Synthesis, Structural Characterization, and Catalytic Activity of Flower Like ZnO Nanostructures

“…Formamides exhibit potential applications in the synthesis of pharmaceutical compounds such as fluoroquinolines, 1 substituted aryl imidazoles, 2 1,2-dihydroquinolines, 3 nitrogenbridged heterocycles 4 etc., Formamides also find its applications in Vilsmeier formylation, 5 preparation of isocyanide, 6 Lewis base organic transformation, allylation and reduction reactions. Formyl group is highly useful as an amino protecting group in peptide synthesis.…”

Excited State Structural Dynamics of Carotenoids and ChargeTransfer Systems

“…To form the aldehyde, dimethylaniline-d6 underwent a Vilsmeir formylation with pyrophosphoryl chloride and dimethyl formamide and was sublimed in a Kugelrohr apparatus to give 4-dimethylaminobenzaldehyde-d6 44 . DCM-d6 was formed by the reaction of 4-dimethylaminobenzaldehyde-d6 and (2,6-Dimethyl-4H-pyran-4-ylidene)malononitrile in the presence of piperidine.…”

Synthesis of N-Formylation of Amines using Various Ion Exchanged Forms of Zeolite-A as Catalysts

“…They have been used in the synthesis of some pharmaceutically important compounds such as Fluoroquinolones [1], 1, 2 dihydro quinolones [2] and Nitrogen based heterocyclic compounds [3]. In Lewis bases, its main importance is to catalyze some important reactions such as allylation [4] and hydrosilyation of carbonyl compounds [5] Formamides Act as useful reagent in Vilsmeier Formylation reaction [6]. The main application of Formamides is to use in the synthesis of Formamidines [7] and in peptide synthesis acts as useful amino protecting group [8].…”