Villoglandular papillary adenocarcinoma of the uterine cervix

Collinet, Pierre; Prolongeau, J. F.; Vaneecloo, Sylvie

doi:10.1016/s0301-2115(99)00047-0

Cited by 24 publications

(11 citation statements)

References 7 publications

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“…Heatley (10) retrospectively collected 140 cases of VGPA and found that 40 cases (28.6%) were associated with squamous or glandular intraepithelial neoplasia. Moreover, to date, various lesions have been described in at least 12 out of 173 cases, including squamous carcinoma, glandular carcinoma, adenosquamous carcinoma and small cell carcinoma (14,(21)(22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature

et al. 2015

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Abstract. To investigate the clinicopathological features, management and prognosis of villoglandular papillary adenocarcinoma (VGPA) of the uterine cervix, the current study presents 4 cases of VGPA of the uterine cervix. The median age of the patients was 55 years (range, 47-70 years), with all 4 patients presenting with stage Ib disease. Human papillomavirus (HPV) infection was detected in 3 patients; this was mainly HPV-16. No history of oral contraceptive use was found in these cases. While 2 of the patients underwent a radical hysterectomy with bilateral salpingo-oophorectomy plus bilateral pelvic lymphadenectomy, 1 patient underwent a radical hysterectomy with bilateral pelvic lymphadenectomy and the remaining patient received a simple total hysterectomy plus post-operative radiotherapy. Of these patients, only 1 had been correctly diagnosed pre-operatively. In 2 patients, the biopsy results had been interpreted as cervical adenocarcinoma, and in the third, the biopsy result was of cervical intraepithelial neoplasia. All 4 patients presented with cervical wall invasion, including invasion of the inner two-thirds in 1 patient. No lymphovascular space invasion or lymph node metastasis was detected. The follow-up time ranged from 49 to 83 months (median, 64 months), and the patients are currently alive and well, with no evidence of recurrent disease. Taking these results as a whole, VGPA is an uncommon type of cervical adenocarcinoma, characterized by its excellent prognosis. HPV infection is associated with the molecular pathogenesis of VGPA, while oral contraceptive use can be excluded. As the disease has a low pre-operative diagnostic accuracy, frequent cervical wall invasion and concomitant lesions, conservative treatment strategies should be carefully considered.

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Section: Discussionmentioning

confidence: 99%

Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature

et al. 2015

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“…However, the four recurred cases reported by MacDonald et al 26 , Korach et al 30 , and Kaku et al 10 reveal an definite discrepancy between the "excellent better prognosis" of VGA described in the original series of 13 subjects by Young and Scully (1989) 1 and subsequent reports by other authors 13,18,20 . MacDonald et al 26 described two recurred VGA subjects: one 32-year-old subject, staged IIB, died from recurrence 2 months later after CCRT.…”

Section: Discussionmentioning

confidence: 86%

Villoglandular Adenocarcinoma of the Uterine Cervix: An Analysis of 12 Clinical Cases

Lai

Chen

et al. 2011

International Journal of Gerontology

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s u m m a r y Background: Villoglandular adenocarcinoma (VGA) of the uterine cervix is a relatively rare subtype of endocervical adenocarcinomas that often occurs in early reproductive women. Methods: Clinical cases were retrospectively collected from the cancer registry systems at Mackay Memorial Hospital (Taipei, Taiwan). Clinical histories on the subjects were extracted directly from chart review of records of clinic visits. Results: The mean age of 12 subjects was 42 years, with 10 and 2 subjects clinically staged as IB1 (10 of 12) and IA2 (2 of 12), respectively, for the period between January 1, 1996, and December 31, 2007. Eleven subjects had classical Type III radical hysterectomy with or without bilateral salpingo-oophorectomy plus bilateral pelvic lymphadenectomy, and one received pelvic and para-aortic lymphadenectomy plus postoperative adjuvant treatment of weekly cisplatin concurrent with radiotherapy. Only one subject had confirmed pelvic lymph nodes metastases. Nine subjects had pure histologic type and others had mixed histologic type of VGA. Only one subject had a recurrence but was still alive. Most subjects were longterm survivors (greater than 5 years) (10 of 12). Conclusion: In conclusion, this study confirms the young age of subjects with VGA and reemphasizes the difficulties in the diagnosis of VGA. Because the current management strategy renders good tumor control in young subjects with early-stage VGA, we would suggest that similar treatment should be considered for elder subjects with this rare category of cervical malignancy. Our experience shows that the primary management of subjects with early-stage VGA (International Federation of Gynecology and Obstetrics Stages IA2 to IIA1) is classical Type III radical hysterectomy plus salpingo-oophorectomy with bilateral pelvic lymphadenectomy at MMH. We hope our 12-case experience may contribute to the clinical decision making for subjects with this disease.

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“…Those authors also described a case in which the hysterectomy specimen showed a "well-differentiated infiltrating component with a rather abundant squamous component" [2]. WDVGA was found in coexistence with an invasive squamous cell carcinoma in a cone biopsy in another case [3]. Finally, Kaku et al [9], in one of their series of seven cases, described a patient with a tumor, 90% of which was a WDVGA and the residual of which was a small cell nonkeratinizing squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 97%

Well-differentiated papillary villoglandular adenocarcinoma of the uterine cervix with a focal high-grade component: is there a need for reassessment?

Fadare

Zheng

2005

Virchows Arch

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Well-differentiated villoglandular adenocarcinoma of the uterine cervix is characterized by an exophytic growth pattern with variably sized papillae that are lined by stratified columnar cells with no more than moderate cytologic atypia. Based on the favorable outcomes in most of the previously reported cases, it has been suggested that some patients with this subtype may be managed conservatively. The case described herein is an otherwise prototypical well-differentiated villoglandular adenocarcinoma but which was associated with a 4.9-mm focus of poorly differentiated carcinoma at its invasive edge. A review of the literature revealed a variety of findings that suggests a need to reassess the potential morphologic and biologic spectrum of this group of tumors. Five of the approximately 89 reported cases were associated with a higher-grade component of the same or a different histologic subtype. At least one patient with apparently stage 1A1 disease was found to have a positive lymph node. Another patient with stage 1B1 disease but no stromal invasion died of her disease following multiple recurrences. Finally, the frequency of lymphovascular invasion and/or lymph node involvement in recent series far exceeds what was found in the two original series. Our case suggests that well-differentiated villoglandular adenocarcinoma is not a diagnosis that should be unequivocally rendered on a small biopsy since other components may be present and the patients may be undertreated. We urge caution when conservative management (cone biopsy alone when margins are negative and there is no lymphovascular invasion) is offered to patients with this tumor since knowledge about its true biologic spectrum appears to still be in evolution.

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Villoglandular papillary adenocarcinoma of the uterine cervix

Cited by 24 publications

References 7 publications

Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature

Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature

Villoglandular Adenocarcinoma of the Uterine Cervix: An Analysis of 12 Clinical Cases

Well-differentiated papillary villoglandular adenocarcinoma of the uterine cervix with a focal high-grade component: is there a need for reassessment?

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