Villain of Molecular Biology: Why are we not reproducible in research?

Abstract

Worldwide, there is an issue of irreproducibility in life science research. In the USA alone $28 billion per year spent on preclinical research is not reproducible. Within this opinion article, I provide a brief historical account of the discovery of the Watson-Crick DNA model and introduce another neglected model of DNA. This negligence may be one of the fundamental reasons behind irreproducibility in molecular biology research.

Dark Side of Molecular Techniques: How to Fix It ?

“…Even various molecular techniques developed so far are based on antiparallel DNA model. We strongly believe that errors reported in various bio-techniques can be resolved by considering both parallel and anti-parallel hybridization of DNA (24). Recently, we have developed a PD-PCR technique by applying the knowledge of both parallel and anti-parallel hybridization of DNA (25).…”