Vigilance troubles in Parkinson's disease: A subjective and objective polysomnographic study

Monaca, Christelle; Duhamel, Alain; Jacquesson, J.; Özsancak, Canan; Destée, Alain; Guieu, J.D.; Defebvre, Luc; Derambure, Philippe

doi:10.1016/j.sleep.2005.12.002

Cited by 66 publications

(55 citation statements)

References 19 publications

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“…As already shown by others [10], ESS correlated significantly with MSL. This supports the use of ESS as a screening tool in clinical practice for EDS in PD patients.…”

Section: Discussionsupporting

confidence: 83%

“…SOREM was found in 29–39% of PD patients with EDS [5,6] and in up to 70% of PD patients with hallucinations [7]. SOREM was also observed in a case of juvenile PD [8] and in 20–28% of unselected PD patients [4,9,10]. Others have reported a less frequent occurrence of SOREM in PD and other forms of parkinsonism [11].…”

Section: Introductionmentioning

confidence: 99%

“…In 6 studies, consecutive unselected PD patients were included [3,4,9,10,12,13]. In 2 studies, only PD patients referred for sleepiness or with ESS >10 were examined [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Excessive Daytime Sleepiness in Parkinson’s Disease: Characteristics and Determinants

et al. 2010

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Background/Aims: Excessive daytime sleepiness (EDS) is frequent in patients with Parkinson’s disease (PD). Occasionally, EDS in PD exhibits narcolepsy-like features. We aimed to assess characteristics and determinants of EDS in consecutive patients with PD. Methods: Thirty consecutive patients with PD underwent a detailed clinical examination. EDS was assessed using the Epworth Sleepiness Scale (ESS) and Multiple Sleep Latency Test (MSLT). Sleep was assessed using video-polysomnography. Cerebrospinal fluid (CSF) hypocretin-1 levels were obtained in 3 patients. Results: ESS was >10 in 17 patients (57%). Mean sleep latency (MSL) on MSLT was <5 min in 11 patients (37%). There was a significant negative correlation between ESS and MSL. None of the 11 patients with MSL <5 min showed a sleep onset REM (SOREM) episode. Patients with EDS had higher dopamine agonists/levodopa equivalent doses, higher apnea/hypopnea index and exhibited wearing-off symptoms more often. Hypocretin-1 was normal in 3 patients tested. Conclusion: EDS, which can sometimes be severe, is common in PD patients even in the absence of SOREM and detectable CSF-hypocretin deficiency. In PD, EDS is a multifaceted phenomenon, the determinants of which include severity of PD, wearing-off symptoms, dosage of antiparkinsonian drugs and sleep-disordered breathing.

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“…As already shown by others [10], ESS correlated significantly with MSL. This supports the use of ESS as a screening tool in clinical practice for EDS in PD patients.…”

Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

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Excessive Daytime Sleepiness in Parkinson’s Disease: Characteristics and Determinants

et al. 2010

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“…An estimated 7% to 42% of patients with PD have experienced sleep attacks or episodes of sudden sleep onset [38][39][40]. Sudden onset of sleep is defi ned as abrupt episodes of unexpected sleep that occur during activities of daily living.…”

Section: Effects Of Pd Treatment On Sleep and Wakefulnessmentioning

confidence: 99%

Sleep disorders and daytime sleepiness in Parkinson’s disease

Monderer

Thorpy²

2009

Curr Neurol Neurosci Rep

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Patients with Parkinson's disease commonly have sleep disturbances that significantly alter quality of life but are often underrecognized. Awareness of the importance of these sleep disorders has been growing, and more research is being conducted. Patients with Parkinson's disease have difficulties that not only include falling asleep and staying asleep but also include excessive daytime sleepiness and abnormal events during sleep. These sleep disturbances are often multifactorial in nature, resulting from degeneration of the cortical sleep centers to effects of medications taken to treat the motor symptoms associated with Parkinson's disease. A thorough evaluation should be performed to assess for the presence of sleep disturbances and daytime sleepiness. Many therapeutic strategies can be used to treat sleepiness and sleep disturbances in Parkinson's disease to improve the patient's overall health, psychological well-being, and quality of life.

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“…The ESS was found to have a sensitivity of 93.5% and a specificity of 100% when compared with the multiple sleep latency tests and maintenance of wakefulness test [27]. In addition, ESS has been found to be significantly correlated with the multiple sleep latency tests in PD patients and is recommended as a screening tool for EDS in PD patients in clinical practice [28]. However, although ESS is a quality tool to evaluate EDS in PD, several issues related to its use should be noted.…”

Section: Discussion/conclusionmentioning

confidence: 91%

Association between Sleep Disturbances and Daytime Somnolence in Parkinson’s Disease

2018

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Background: Sleep disturbance is a common problem among patients with Parkinson’s disease (PD). Objectives: To investigate the prevalence of daytime somnolence and night-time sleep disturbances; to characterise the night-time sleep disturbance in patients with daytime somnolence; and to determine the correlation between daytime somnolence and night-time sleep disturbances. Methods: One hundred and sixty patients with PD were included in the study. Each patient completed the Thai version of the Epworth Sleepiness Scale (ESS) questionnaire to evaluate excessive daytime sleepiness (EDS), and the PD Sleep Scale version-2 (PDSS-2) questionnaire to evaluate night-time sleep disturbance. Subjective sleep information and details about the presence or absence of sleep attack (SA) were also obtained from the patients. Results: The types of daytime somnolence found in this study were EDS, SA, and combination of EDS and SA (EDS + SA) with the prevalence rates of 22.5, 3.1 and 6.3%, respectively. The prevalence of night-time sleep disturbance was 46.9%. The most common nocturnal disturbance (82.5%) was “get up at night to pass urine”. There was a significant positive correlation between the ESS score and PDSS-2 total score with a correlation coefficient of 0.16 (p = 0.043). Patients with “EDS + SA” were the most affected by nocturnal disturbances, as they represented the largest group among those patients with night-time disturbances and had the highest PDSS-2 total score (p < 0.05). Conclusion: There are differences in nocturnal sleep disturbances among PD patients with different types of daytime somnolence. The significant positive correlation between the ESS and the PDSS-2 total scores suggests that night-time sleep disturbance may influence daytime somnolence.

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Vigilance troubles in Parkinson's disease: A subjective and objective polysomnographic study

Cited by 66 publications

References 19 publications

Excessive Daytime Sleepiness in Parkinson’s Disease: Characteristics and Determinants

Excessive Daytime Sleepiness in Parkinson’s Disease: Characteristics and Determinants

Sleep disorders and daytime sleepiness in Parkinson’s disease

Association between Sleep Disturbances and Daytime Somnolence in Parkinson’s Disease

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