Vigilance to Limit the Bidirectional Introduction and Co-circulation of Virus Serotypes Aims to Reduce Risk of Severe Dengue Disease in North East India

Barnett, Leonie J.; Taylor‐Robinson, Andrew W.

doi:10.4172/2472-4998.1000115

Cited by 4 publications

(3 citation statements)

References 24 publications

(36 reference statements)

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“…The absence of effective vaccines and antiviral drugs against dengue creates great hardships in clinical disease management [32]. Challenges to vaccine design include the noted phenomenon of enhanced pathology upon secondary infection by a serotype heterologous to that which caused primary infection, as well as genomic diversity between genotypes and serotypes of DENV.…”

Section: Dengue Control: Current Schemes and Their Limitationsmentioning

confidence: 99%

Dengue Serotypes in Bangladesh: Whole Genome Sequencing and Comparative Genomics Facilitates Pathogenesis and Epidemiology Studies and Informs Improved Disease Control

Tabassum¹,

Taylor‐Robinson²

2019

Microbiol Infect Dis

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Dengue virus (DENV) is one of the most extensive arthropod-borne (arbo)viruses worldwide, especially prevalent in tropical and subtropical countries, and which is responsible for causing an array of clinical disease manifestations in humans. The increasing frequency of dengue outbreaks and the expanding range over which both the virus and its vector of transmission, female Aedes mosquitoes, are endemic, are pressing global public health concerns. The ongoing lack of either an efficacious vaccine or antiviral drug has contributed to the escalating problem. Inadequate knowledge of DENV genomic architecture and pathogenesis has proven to be a major drawback when designing effective prevention and treatment options. Mounting case numbers of dengue infection are reported each year in Bangladesh, yet no full-length genome sequence data are available for DENV isolates from this densely populated, developing South Asian nation. Sequencing and characterization of the whole genome of Bangladeshi DENV isolates of different virus serotypes is therefore an important priority in order to identify therapeutic target determinants against which to develop effective measures to combat the disease.

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Section: Dengue Control: Current Schemes and Their Limitationsmentioning

confidence: 99%

Dengue Serotypes in Bangladesh: Whole Genome Sequencing and Comparative Genomics Facilitates Pathogenesis and Epidemiology Studies and Informs Improved Disease Control

Tabassum¹,

Taylor‐Robinson²

2019

Microbiol Infect Dis

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“…Different dengue serotypes vary in their capacity to cause severe illness, but there is no expert consensus as to the extent of a causal association [36]. Multiple serotypes are in circulation in many regions of dengue endemicity, including the highly populated Indian subcontinent [37].…”

Section: Dengue Virus Serotypes Immunity and Immunopathologymentioning

confidence: 99%

Cross-Reactivity of Non-Neutralizing Antibodies to Dengue and Zika Viruses: Implications for Vaccination

Taylor‐Robinson¹

2017

Arch Prev Med

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Dengue is the leading vector-borne viral disease of humans and poses a major international public health concern in tropical and subtropical regions in which it is endemic. Cross-reactivity among the different serotypes of dengue virus promotes antibody-dependent enhancement of secondary infection, an immunopathological response that is thought to amplify viral replication and thereby to increase disease severity. The previously relatively neglected fellow fl avivirus Zika has now emerged strikingly in countries where dengue virus is endemic, notably across Latin America. Recent reports suggest that anti-dengue virus antibody can potentiate Zika virus replication. Conversely, it appears that anti-Zika virus antibody may exacerbate dengue infection. Such pre-existing immunity against one fl avivirus may not only confuse the diagnosis of disease produced by infection with a heterologous fl avivirus, but conceivably affect the clinical outcome. The existence of non-neutralizing antibodies to a prior dengue or Zika infection can result in worse disease manifestations upon infection with a secondary, heterologous fl avivirus. This has important implications for the administration of vaccines currently in development, immunization with which will promote the generation of homotypic fl avivirus antibodies but that may have an unintended adverse effect of raising susceptibility to heterologous infection of either dengue or Zika.

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“…Improved community education is called for in the furtherance of reducing this contemporary cause of dengue vector spread. To date, very few studies have been conducted to evaluate the cause and effect of variables on the frequent dengue outbreaks in different regions of India [20].…”

Section: Current Control Measuresmentioning

confidence: 99%

Vector Control Interventions to Prevent Dengue: Current Situation and Strategies for Future Improvements to Management of Aedes in India

Singh¹,

Taylor‐Robinson²

2017

J Emerg Infect Dis

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Vigilance to Limit the Bidirectional Introduction and Co-circulation of Virus Serotypes Aims to Reduce Risk of Severe Dengue Disease in North East India

Cited by 4 publications

References 24 publications

Dengue Serotypes in Bangladesh: Whole Genome Sequencing and Comparative Genomics Facilitates Pathogenesis and Epidemiology Studies and Informs Improved Disease Control

Dengue Serotypes in Bangladesh: Whole Genome Sequencing and Comparative Genomics Facilitates Pathogenesis and Epidemiology Studies and Informs Improved Disease Control

Cross-Reactivity of Non-Neutralizing Antibodies to Dengue and Zika Viruses: Implications for Vaccination

Vector Control Interventions to Prevent Dengue: Current Situation and Strategies for Future Improvements to Management of Aedes in India

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