Cognitive behavioral therapy (CBT) is considered to be an evidence-based psychological intervention for a wide range of mental health issues. This article systematically reviewed published empirical studies of CBT adapted for use within a religious context, specifically Islamically modified CBT (iCBT) for Muslims. The aim was to determine the extent to which this therapy can be considered an empirically supported treatment. We searched Medline, Embase, Education Resources Information Center/ProQuest, ScienceDirect, PubMed, APA PsycInfo, Cumulated Index to Nursing and Allied Health Literature, Scopus, Google Scholar, and evidence-based medicine Reviews (Cochrane Central Register of Controlled Trials). All articles from inception to April 25, 2022 were included. The general inclusion criteria were patients of all age groups, primary diagnosis of any mental health issue, and CBT with components derived from Islam. Of the 2,091 unique articles identified during the initial search, nine studies with a total of 622 participants met our inclusion criteria. These comprised seven experimental design studies and two single-case design studies. The mental health outcomes were predominantly assessed through measures such as Hamilton Anxiety Rating Scale, Hamilton Depression Rating Scale, Beck Anxiety Inventory (BAI), etc. The findings indicated that iCBT interventions incorporating religious aspects showed potential benefits in reducing symptoms and improving functioning among religious individuals with mood and anxiety disorders. iCBT is a therapeutic approach informed by Muslim clients’ own Islamic beliefs, practices, and resources. It may help clients with mental health issues to develop thoughts and behaviors that enhance mental well-being. Our findings indicated that modifying CBT by adding religious/Islamic aspects may be suitable management for religious Muslims with mental health issues. The results are promising but require confirmation and refinement by further research.