Views of American Oncologists About the Purposes of Clinical Trials

Joffe, Steven; Weeks, Jane C.

doi:10.1093/jnci/94.24.1847

Cited by 88 publications

(54 citation statements)

References 34 publications

(33 reference statements)

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“…Although there are some reports of the views of nurses 54,55 and some of the views of GP recruiters, 37,56-58 the research samples available are largely comprised of senior doctors involved in trials, with a strong bias towards oncology trials. 32,[41][42][43]45,59,[60][61][62] No research was identified that describes the attitudes of coordinating staff [although see Rico-Villademoros and colleagues 63 for a survey-based description of the role of the clinical research coordinator (data manager) in oncology trials].…”

Section: Recruitment Of Intervieweesmentioning

confidence: 99%

Recruitment to randomised trials: strategies for trial enrolment and participation study. The STEPS study

Campbell

Snowdon²,

Francis³

et al. 2007

Health Technol Assess

391

403

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Section: Recruitment Of Intervieweesmentioning

confidence: 99%

Recruitment to randomised trials: strategies for trial enrolment and participation study. The STEPS study

Campbell

Snowdon²,

Francis³

et al. 2007

Health Technol Assess

391

403

View full text Add to dashboard Cite

show abstract

“…One answer could be that they were not aware because they believed that the experiment really would benefit the patients-that the investigators suffered from their own therapeutic misconception. This interpretation has begun to surface in the literature (Appelbaum 2002;Joffe and Weeks 2002;Miller 2000). Further research might examine how investigators assemble and sustain their own therapeutic misconception and to what extent it varies in different research settings or with different subjects.…”

Section: Resultsmentioning

confidence: 99%

Communication and Miscommunication in Informed Consent to Research

Sankar

2004

Med Anthropol Q

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Biomedical ethics require that research subjects be aware that the drugs they take or procedures they undergo are designed to fulfill the conditions of the experiment and not to benefit a subject's health. This apparently straightforward distinction between research and treatment is a source of much controversy and misunderstanding. Ethicists have labeled this problem the "therapeutic misconception." This misconception and, more broadly, informed consent have been studied extensively. Nonetheless, the therapeutic misconception persists among research subjects. This paper argues that one factor overlooked in the persistence of the therapeutic misconception is the effect of the theoretical paradigm that guides the practice and analysis of informed consent. The paradigm poses an idealized model of communication that ignores social context. This paper examines informed consent practices associated with a cancer research trial to demonstrate an alternative approach to studying informed consent to research. Through analysis of informed consent session transcripts, it demonstrates the importance of taking account of not only what is said, but how and by whom it is said.

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“…We found that the participants who understood gene therapy (OR, 6.560; p= 0.000) or who suggested that their patients enrol in cancer clinical trials (OR, 2.375; p=0.044) evaluated the safety of the treatment at a higher level. Joffe and colleagues demonstrated that the purpose of oncology physicians in suggesting that their patients enrol in clinical trials was to let them receive a state-of-the-art treatment or to improve the treatment of future patients [24]. Physicians who have the aforementioned ideas may easily accept and adopt the results of phase III trial.…”

Section: Discussionmentioning

confidence: 99%

The Attitude of Oncology Physicians and Nurses to the Acceptance of New Drugs for Gene Therapy

Liu

et al. 2010

J Canc Educ

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With the efficacy of gene therapy verified in phase III trials, cancer patients will consider whether to accept gene therapy sooner or later. The purpose of this study is to investigate the attitudes of oncology physicians and nurses regarding effective gene therapy. A questionnaire was administered to 368 oncology physicians and nurses. A total of 328 valid questionnaires were returned (response rate, 89.1%). Gene therapy was considered as very safe or safe by 256 (78.0%) participants. Regardless of the stage of cancer, participants who advised patients to enroll in clinical trials and considered gene therapy as safe tended to accept the effective gene therapy. Gene therapy is considered to be a safe treatment. Most participants are willing to accept effective and verified gene therapy on the assumption that they themselves suffer from cancers.

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Views of American Oncologists About the Purposes of Clinical Trials

Cited by 88 publications

References 34 publications

Recruitment to randomised trials: strategies for trial enrolment and participation study. The STEPS study

Recruitment to randomised trials: strategies for trial enrolment and participation study. The STEPS study

Communication and Miscommunication in Informed Consent to Research

The Attitude of Oncology Physicians and Nurses to the Acceptance of New Drugs for Gene Therapy

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