Viewing Cancer Through the Lens of Corruption: Using Behavioral Ecology to Understand Cancer

Bukkuri, Anuraag; Adler, Frederick R.

doi:10.3389/fevo.2021.678533

Cited by 7 publications

(8 citation statements)

References 129 publications

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“…Without a permissive or even supportive environment, the clone will very likely not survive. Via this dialogue [48], cancer cells are able to recruit or even corrupt [49] the various cells around them, including tissue fibroblasts. In recent years, it has become widely recognised that epigenetic alterations are essential for regulating CAF bioactivity [50].…”

Section: Origin Of Cafsmentioning

confidence: 99%

Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

Vokurka

Lacina

Brábek

et al. 2022

IJMS

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Cancer-associated fibroblasts (CAFs) are an essential component of the tumour microenvironment. They represent a heterogeneous group of cells that are under the control of cancer cells and can reversely influence the cancer cell population. They affect the cancer cell differentiation status, and the migration and formation of metastases. This is achieved through the production of the extracellular matrix and numerous bioactive factors. IL-6 seems to play the central role in the communication of noncancerous and cancer cells in the tumour. This review outlines the role of exosomes in cancer cells and cancer-associated fibroblasts. Available data on the exosomal cargo, which can significantly intensify interactions in the tumour, are summarised. The role of exosomes as mediators of the dialogue between cancer cells and cancer-associated fibroblasts is discussed together with their therapeutic relevance. The functional unity of the paracrine- and exosome-mediated communication of cancer cells with the tumour microenvironment represented by CAFs is worthy of attention.

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Section: Origin Of Cafsmentioning

confidence: 99%

Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

Vokurka

Lacina

Brábek

et al. 2022

IJMS

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“…Whelan et al (2020) propose to eradicate cancer cell by information disruption, similar to habitat fragmentation driving population extinction. Schmidt, 2017;Whelan et al, 2020;Bukkuri and Adler, 2021;Miller et al, 2021 Cancer heterogeneity and genome instability: Heterogeneity is a fundamental property of cancer cells within a tumor, both genetically and phenotypically.…”

Section: Adler and Gordon 2019mentioning

confidence: 99%

Ecology of Human Medical Enterprises: From Disease Ecology of Zoonoses, Cancer Ecology Through to Medical Ecology of Human Microbiomes

Sam

Zhang²

2022

Front. Ecol. Evol.

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In nature, the interaction between pathogens and their hosts is only one of a handful of interaction relationships between species, including parasitism, predation, competition, symbiosis, commensalism, and among others. From a non-anthropocentric view, parasitism has relatively fewer essential differences from the other relationships; but from an anthropocentric view, parasitism and predation against humans and their well-beings and belongings are frequently related to heinous diseases. Specifically, treating (managing) diseases of humans, crops and forests, pets, livestock, and wildlife constitute the so-termed medical enterprises (sciences and technologies) humans endeavor in biomedicine and clinical medicine, veterinary, plant protection, and wildlife conservation. In recent years, the significance of ecological science to medicines has received rising attentions, and the emergence and pandemic of COVID-19 appear accelerating the trend. The facts that diseases are simply one of the fundamental ecological relationships in nature, and the study of the relationships between species and their environment is a core mission of ecology highlight the critical importance of ecological science. Nevertheless, current studies on the ecology of medical enterprises are highly fragmented. Here, we (i) conceptually overview the fields of disease ecology of wildlife, cancer ecology and evolution, medical ecology of human microbiome-associated diseases and infectious diseases, and integrated pest management of crops and forests, across major medical enterprises. (ii) Explore the necessity and feasibility for a unified medical ecology that spans biomedicine, clinical medicine, veterinary, crop (forest and wildlife) protection, and biodiversity conservation. (iii) Suggest that a unified medical ecology of human diseases is both necessary and feasible, but laissez-faire terminologies in other human medical enterprises may be preferred. (iv) Suggest that the evo-eco paradigm for cancer research can play a similar role of evo-devo in evolutionary developmental biology. (v) Summarized 40 key ecological principles/theories in current disease-, cancer-, and medical-ecology literatures. (vi) Identified key cross-disciplinary discovery fields for medical/disease ecology in coming decade including bioinformatics and computational ecology, single cell ecology, theoretical ecology, complexity science, and the integrated studies of ecology and evolution. Finally, deep understanding of medical ecology is of obvious importance for the safety of human beings and perhaps for all living things on the planet.

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“…Скорости обусловленных ею изменений клеточных популяций разные в зависимости от внутриорганизменных факторов селекции, а злокачественный рост является кульминацией этих процессов, достигаемой, когда популяция опухолевых клеток совсем выходит из-под под контроля, и родной организм становится для этого, в некотором смысле преступного, сообщества клеток всего лишь содержащей нужные ресурсы средой обитания. К слову сказать, для анализа взаимоотношений между опухолью и организмом используют еще и экономические термины и категории, например «надувательство» (cheating) и «коррупция», и есть соответствующие теории [7, 14,16].…”

Section: конвергентная эволюция или рекапитуляция?unclassified

Общие Принципы Взаимоотношений Живых Организмов С Экосистемой И Злокачественных Клеток С Живым Организмом

Голубев¹

2022

Biosfera

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The present review addresses studies based on behavioral similarities between cancer cells in a metazoan organism and unicellular organisms in an ecosystem and between malignant tumors and some primordial colonial forms of life, from which metazoans evolved. Unicellular organisms and their colonies can exist only by compensating for their losses by the proliferation of remaining cells. Therefore, proliferation or readiness to proliferate is a priority for cells. Metazoans evolution was associated with increasing the stringency of the control of this priority. In this perspective, the common set of cancer hallmarks, which emerges in the courses of progression of different cancers, which feature different initial combinations of mutations in oncogenes and antioncogenes and exist under different initial conditions possible in various organs, results not from the convergent evolution but rather from the recapitulation of the evolutionary primordial mode of cell life. The malignant transformation is a manifestation of the disinhibition of a gestalt of traits required for the survival of cell populationin an ecosystem, which is what a tumor host eventually turns to for the tumor. Such ecological attitudes to malignant growth suggest analogies betweenthe therapeutic resistance of cancer with the resistance of pests to pesticides or of bacteria to antibiotics and between metastases and invasive species. An important means used by unicellular organisms to survive in noxious conditions is increasing the rate of mutation to produce different variants, among which some may happen to fit the current situation. This is what occurs upon cancer therapy, which increases the genetic diversity of cancer cells and acts as a factor of the positive selection of cells for resistance to the very same therapy. Because the resulting cell clones compete for body resources, the elimination of the cells that respond to therapy is favorable for the cells that are resistant to it. Therefore, it is unwise to use chemotherapy for tumor elimination. It is more prudent to aim at achieving a balance of cancer cell populations, which makes it possible to turn cancer into a chronic rather than fatal disease. These arguments justify the current efforts to develop regiments of the so-called adaptive therapy for cancer.

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Viewing Cancer Through the Lens of Corruption: Using Behavioral Ecology to Understand Cancer

Cited by 7 publications

References 129 publications

Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

Ecology of Human Medical Enterprises: From Disease Ecology of Zoonoses, Cancer Ecology Through to Medical Ecology of Human Microbiomes

Общие Принципы Взаимоотношений Живых Организмов С Экосистемой И Злокачественных Клеток С Живым Организмом

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