Vieillissement et intégrité de la peau

Rorteau, Julie; Chevalier, Fabien; Fromy, Bérengère; Lamartine, Jérôme

doi:10.1051/medsci/2020223

Cited by 11 publications

(3 citation statements)

References 41 publications

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“…A derme, composta por elementos celulares e acelulares, é a camada que contém as fibras colágenas e elásticas, sendo um dos elementos responsáveis pela formação das rugas. Resiste à penetração da agulha por ser tecido firme, compacto e pouco distensível; é bastante vascularizada e contém terminações nervosas (Rorteau et al, 2020).…”

Section: Resultsunclassified

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A estética e harmonização orofacial

Teodoro,

Suguihara,

Muknicka

2023

RSD

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O processo de envelhecimento afeta todas as estruturas do rosto, porém, o início e a velocidade das alterações variam entre cada estrutura específica, indivíduo e grupos étnicos distintos. Portanto, o conhecimento da anatomia relacionada ao envelhecimento é crucial para o trabalho de um especialista em harmonização orofacial, ao realizar um procedimento visando restaurar as estruturas faciais e proporcionar uma aparência mais jovem. Esta revisão tem como objetivo o entendimento atual da anatomia facial humana e busca esclarecer as transformações que ocorrem nos ossos, ligamentos, músculos, gordura e pele durante o envelhecimento. Além disso, destaca-se o papel desempenhado pelo profissional na área de harmonização orofacial nos tratamentos rejuvenescedores, incluindo o uso de toxina botulínica e preenchedores faciais, com ênfase no ácido hialurônico.

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Section: Resultsunclassified

“…Encontram-se nos limites da derme profunda. As glândulas apócrinas estão situadas principalmente nas axilas e regiões inguinal e perianal, além de outras pequenas áreas no tegumento (relação com hidradenite supurativa grave disseminada) (Rorteau et al, 2020).…”

Section: Resultsunclassified

A estética e harmonização orofacial

Teodoro,

Suguihara,

Muknicka

2023

RSD

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“…66 Moreover, with the aging process of the skin, the three layers of skin (epidermis, dermis, and hypodermis) undergo degenerative changes, and alterations of the dermis are the most obvious. [67][68][69][70] The hypodermis is the deepest layer of the skin and is present between dermis and underlying tissues underneath such as muscle. It consists mainly of adipocytes and ECM; therefore, we did not include hypodermis in this study.…”

Section: Discussionmentioning

confidence: 99%

Relation Between Reactive Oxygen Species Production and Transient Receptor Potential Vanilloid1 Expression in Human Skin During Aging

Favero,

Gianò,

Franco

et al. 2024

J Histochem Cytochem.

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Skin sensitivity and impaired epidermal barrier function are associated with aging and are at least partly due to increased production of reactive oxygen species (ROS). Transient receptor potential vanilloid1 (TRPV1) is expressed in keratinocytes, fibroblasts, mast cells, and endothelial cells in skin. We investigated in skin biopsies of adult and elderly donors whether TRPV1 expression is involved in the skin aging process. We found that aging skin showed a strongly reduced epidermal thickness, strongly increased oxidative stress, protease expression, and mast cell degranulation and strongly increased TRPV1 expression both in epidermis and dermis. Based on our findings, the aging-related changes observed in the epidermis of the skin level are associated with increased ROS production, and hypothesized alterations in TRPV1 expression are mechanistically linked to this process.

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How good is the evidence that cellular senescence causes skin ageing?

Low

Alimohammadiha

Smith

et al. 2021

Ageing Research Reviews

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Skin is the largest organ of the body with important protective functions, which become compromised with time due to both intrinsic and extrinsic ageing processes. Cellular senescence is the primary ageing process at cell level, associated with loss of proliferative capacity, mitochondrial dysfunction and significantly altered patterns of expression and secretion of bioactive molecules. Intervention experiments have proven cell senescence as a relevant cause of ageing in many organs. In case of skin, accumulation of senescence in all major compartments with ageing is well documented and might be responsible for most, if not all, the molecular changes observed during ageing. Incorporation of senescent cells into in-vitro skin models (specifically 3D full thickness models) recapitulates changes typically associated with skin ageing. However, crucial evidence is still missing. A beneficial effect of senescent cell ablation on skin ageing has so far only been shown following rather unspecific interventions or in transgenic mouse models. We conclude that evidence for cellular senescence as a relevant cause of intrinsic skin ageing is highly suggestive but not yet completely conclusive.

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Vieillissement et intégrité de la peau

Cited by 11 publications

References 41 publications

A estética e harmonização orofacial

A estética e harmonização orofacial

Relation Between Reactive Oxygen Species Production and Transient Receptor Potential Vanilloid1 Expression in Human Skin During Aging

How good is the evidence that cellular senescence causes skin ageing?

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