Videofluoroscopic Swallowing Study Features and Resting-State Functional MRI Brain Activity for Assessing Swallowing Differences in Patients with Mild Cognitive Impairment and Risk of Dysphagia

Wang, Jie; Yang, Cheng; Wei, Xiaomei; Zhang, Mengqing; Dai, Meng; Huang, Guohang; Huang, Wenhao; Wen, Hongmei; Dou, Zulin

doi:10.1007/s00455-022-10460-2

Cited by 3 publications

(4 citation statements)

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“…Cranial imaging was usually not available in these studies, so subcortical vascular encephalopathy (SVE) could not be detected as a possible cause of dysphagia, although the strong association between SVE and OD has been confirmed in many studies, as demonstrated by the meta-analysis by Alvar and colleagues [29]. The same is true for the association of dementia [4,48,49], mild cognitive impairment [36,37,50], and delirium [29,39,51] with OD, which has not been considered an underlying neurological disease associated with OD in most studies. In addition, it should be mentioned that objective dysphagia diagnosis using videofluoroscopy was implemented only in one of the previous studies considered [52].…”

Section: Discussionmentioning

confidence: 98%

“…If a MoCA below 20 points was not associated with delirium or dementia, this was categorized as a non-classifiable cognitive disfunction. Both MCI and non-classifiable cognitive disfunction were categorized as relevant neurological diseases in this context because they were proven to be associated with dysphagia [ 36 , 37 ]. In addition to neurological diseases typically associated with oropharyngeal dysphagia [ 38 ], delirium and SVE were also classified as relevant neurological diseases because they are highly associated with dysphagia [ 29 , 39 ].…”

Section: Methodsmentioning

confidence: 99%

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Sarcopenic Dysphagia Revisited: A Cross-Sectional Study in Hospitalized Geriatric Patients

et al. 2023

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Oropharyngeal dysphagia (OD) is a frequent finding in older patients with potentially lethal complications such as aspiration pneumonia, malnutrition, and dehydration. Recent studies describe sarcopenia as a causative factor for OD, which is occasionally referred to as “sarcopenic dysphagia” in the absence of a neurogenic etiology. In most of the previous studies on sarcopenic dysphagia, the diagnosis was based only on clinical assessment. In this study, flexible endoscopic evaluation of swallowing (FEES) was used as an objective method to evaluate the presence of OD, its association with sarcopenia, and the presence of pure sarcopenic dysphagia. In this retrospective cross-sectional study, 109 acute care geriatric hospital patients with suspected OD received FEES examination and bioimpedance analysis (BIA) in clinical routine. 95% of patients had at least one neurological disease, 70% fulfilled the criteria for sarcopenia, and 45% displayed moderate or severe OD. Although the prevalence of sarcopenia and OD was high, there was no significant association between OD and sarcopenia. Considering these results, both the association between sarcopenia and OD and pure sarcopenic dysphagia appear questionable. Further prospective studies are needed to elucidate if sarcopenia is merely an epiphenomenon of severe disease or whether it plays a causative role in the development of OD.

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Section: Discussionmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Sarcopenic Dysphagia Revisited: A Cross-Sectional Study in Hospitalized Geriatric Patients

et al. 2023

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“…Some correlation analyses indicated that the ALFF values of the AG, even in different bands, could be correlated positively with the MMSE score. With the development of MCI, the ALFF values of such patients in the regions mentioned above tend to decline along with their cognition level (Wang et al, 2022 ). Therefore, it was speculated that dysfunctional activities of nerve cells in the AG could be one of the leading causes of poor verbal working memory expression involving short-term storage and retrieval of phonological representations (Jonides et al, 1998 ; Bokde et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis

Yang

Song

Chen

et al. 2023

Front. Aging Neurosci.

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BackgroundMild cognitive impairment (MCI) depicts a transitory phase between healthy elderly and the onset of Alzheimer's disease (AD) with worsening cognitive impairment. Some functional MRI (fMRI) research indicated that the frontoparietal network (FPN) could be an essential part of the pathophysiological mechanism of MCI. However, damaged FPN regions were not consistently reported, especially their interactions with other brain networks. We assessed the fMRI-specific anomalies of the FPN in MCI by analyzing brain regions with functional alterations.MethodsPubMed, Embase, and Web of Science were searched to screen neuroimaging studies exploring brain function alterations in the FPN in MCI using fMRI-related indexes, including the amplitude of low-frequency fluctuation, regional homogeneity, and functional connectivity. We integrated distinctive coordinates by activating likelihood estimation, visualizing abnormal functional regions, and concluding functional alterations of the FPN.ResultsWe selected 29 studies and found specific changes in some brain regions of the FPN. These included the bilateral dorsolateral prefrontal cortex, insula, precuneus cortex, anterior cingulate cortex, inferior parietal lobule, middle temporal gyrus, superior frontal gyrus, and parahippocampal gyrus. Any abnormal alterations in these regions depicted interactions between the FPN and other networks.ConclusionThe study demonstrates specific fMRI neuroimaging alterations in brain regions of the FPN in MCI patients. This could provide a new perspective on identifying early-stage patients with targeted treatment programs.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023432042, identifier: CRD42023432042.

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“…The quantitative of VFSS based on pathological samples collected from a wide range of individuals with multiple diseases, the extraction of the most effective and valuable information from dysphagia angiography and the objective comparison of the levels of functionality within-patients before and after treatment, as well as between patients, can fully meet the comprehensive needs of scientific research, stimulate more innovative research, and generate ideas and references for the evaluation and follow-up treatment of dysphagia. For now, the quantitative analysis of VFSS is mainly used to describe the physiological state of swallowing ( 14 , 38 ), explore the pathological and physiological characteristics of swallowing in different diseases ( 23 , 39 ), analyze the effects of age, gender, texture of food balls and other factors on swallowing ( 40 , 41 ), and evaluate treatment efficacy ( 42 , 43 ). In the future, the quantitative results should be used for evaluation, and future studies should assess other valuable parameters and improve those with poor reliability, validity, and matching.…”

Section: Discussionmentioning

confidence: 99%

Findings of a videofluoroscopic swallowing study in patients with dysphagia

Cui

Wei

et al. 2023

Front. Neurol.

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ObjectiveSwallowing examination is crucial in patients with dysphagia. We aimed to compare qualitative and quantitative videofluoroscopic swallowing study (VFSS) results to provide reference for standardizing quantitative parameters.Materials and methodsIn total, 117 patients with dysphagia were included, 38 with Parkinson’s disease and 39 and 40 in convalescence following cerebral hemorrhage and infarction. VFSS was both qualitatively and quantitatively analyzed.ResultsA significant difference of Oral transit time was found between the oral motor function grades (p < 0.001), also was swallowing reaction times found between swallowing reaction duration grades (p < 0.001), and soft palate lift duration between the soft palate lift grades (p < 0.001). Superior hyoid bone movement (p < 0.001), anterior hyoid bone movement (p < 0.001), hyoid pause time (p < 0.001), and hyoid movement duration (p = 0.032) had significant differences between the hyoid laryngeal complex movement grades, as did the pharyngeal cavity transit time among the cricopharyngeal muscle opening duration grades (p < 0.001). The laryngeal vestibule closure duration differed among the glottic closure grades (p < 0.001). No statistically significant difference in upper esophageal sphincter opening diameter (p = 0.682) or duration (p = 0.682) among the cyclopharyngeal muscle opening duration grades. The pharyngeal area at rest did not significantly differ among the different vallecular residue (p = 0.202) and pyriform sinus residue (p = 0.116) grades.ConclusionSeveral quantitative parameters can reflect the swallowing assessment process well. Further optimization of quantitative parameters is recommended.

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Videofluoroscopic Swallowing Study Features and Resting-State Functional MRI Brain Activity for Assessing Swallowing Differences in Patients with Mild Cognitive Impairment and Risk of Dysphagia

Cited by 3 publications

References 56 publications

Sarcopenic Dysphagia Revisited: A Cross-Sectional Study in Hospitalized Geriatric Patients

Sarcopenic Dysphagia Revisited: A Cross-Sectional Study in Hospitalized Geriatric Patients

Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis

Findings of a videofluoroscopic swallowing study in patients with dysphagia

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