Videodensitometric measurements in contrast-echocardiology

Gustavsson, Tomas; Beckman-Suurküla, M.

doi:10.1109/cic.1996.542635

Cited by 2 publications

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“…The conditions stated in (5) and (6) express the fast injection hypothesis and the mass conservation law, respectively. Equation (4) represents the link between the statistical and the physical interpretation of the dilution process. In order to obtain a model to describe the IDC, we must focus on a fixed section of the tube (detection section) where the concentration of the indicator is evaluated versus time (see Figure 1).…”

Section: Injector Detection Sectionmentioning

confidence: 99%

“…As these techniques require catheterization, they are considered invasive. The development of sufficiently stable ultrasound contrast agents (UCA) has led to the consideration of their applicability as indicators in dilution techniques [1,2,3,4]. UCA are microbubbles (diameter of few µm) of gas stabilized by a shell of biocompatible material, which are easily detectable by ultrasound analysis [5].…”

Section: Introductionmentioning

confidence: 99%

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Videodensitometric Methods for Cardiac Output Measurements

Mischi

Kalker

Korsten

2003

EURASIP J. Adv. Signal Process.

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Cardiac output is often measured by indicator dilution techniques, usually based on dye or cold saline injections. Developments of more stable ultrasound contrast agents (UCA) are leading to new noninvasive indicator dilution methods. However, several problems concerning the interpretation of dilution curves as detected by ultrasound transducers have arisen. This paper presents a method for blood flow measurements based on UCA dilution. Dilution curves are determined by real-time densitometric analysis of the video output of an ultrasound scanner and are automatically fitted by the Local Density Random Walk model. A new fitting algorithm based on multiple linear regression is developed. Calibration, that is, the relation between videodensity and UCA concentration, is modelled by in vitro experimentation. The flow measurement system is validated by in vitro perfusion of SonoVue contrast agent. The results show an accurate dilution curve fit and flow estimation with determination coefficient larger than 0.95 and 0.99, respectively

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Section: Injector Detection Sectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Videodensitometric Methods for Cardiac Output Measurements

Mischi

Kalker

Korsten

2003

EURASIP J. Adv. Signal Process.

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Cardiac Image Segmentation for Contrast Agent Videodensitometry

Mischi

Kalker

Korsten

2005

IEEE Trans. Biomed. Eng.

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Abstract-Indicator dilution techniques are widely used in the intensive care unit and operating room for cardiac parameter measurements. However, the invasiveness of current techniques represents a limitation for their clinical use. The development of stable ultrasound contrast agents allows new applications of the indicator dilution method. Ultrasound contrast agent dilutions permit an echographic noninvasive measurement of cardiac output, ejection fraction, and blood volumes. The indicator dilution curves are measured by videodensitometry of specific regions of interest and processed for the cardiac parameter assessment. Therefore, the major indicator dilution imaging issue is the detection of proper contrast videodensitometry regions that maximize the signal-to-noise ratio of the measured indicator dilution curves. This paper presents an automatic contour detection algorithm for indicator dilution videodensitometry. The algorithm consists of a radial filter combined with an outlier correction. It maximizes the region of interest by excluding cardiac structures that act as interference to the videodensitometric analysis. It is fast, projection independent, and allows the simultaneous detection of multiple contours in real time. The system is compared to manual contour definition on both echographic and magnetic resonance images.

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Videodensitometric measurements in contrast-echocardiology

Cited by 2 publications

References 1 publication

Videodensitometric Methods for Cardiac Output Measurements

Videodensitometric Methods for Cardiac Output Measurements

Cardiac Image Segmentation for Contrast Agent Videodensitometry

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