Video Capsule Enteroscopy in the Diagnosis of Celiac Disease: A Multicenter Study

Rondonotti, Emanuele; Spada, Cristiano; Cave, David R.; Pennazio, Marco; Riccioni, Maria Elena; Vitis, I. De; Schneider, David A.; Sprujevnik, Tatiana; Villa, Federica; Langelier, Jennifer; Arrigoni, Arrigo; Costamagna, Guido; Franchis, Roberto de

doi:10.1111/j.1572-0241.2007.01238.x

Cited by 166 publications

(126 citation statements)

References 30 publications

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“…When compared to upper GI endoscopy, capsule endoscopy reported an identical specificity (100%); a tendency towards a better sensitivity (70% vs 60%); and a positive predictive value and negative predictive value of 100% and 77%, respectively. These data were confirmed by recent studies [17,19] . Hopper et al [17] showed that 17 out of 20 patients with celiac disease had villous atrophy also detected by capsule endoscopy.…”

Section: Capsule Endoscopysupporting

confidence: 82%

“…Scalloping, mosaicism, micronodularity and reduction of folds ( Figure 2) can all be seen by capsule endoscopy [16,19,22] . In addition to general mucosal pattern, capsule endoscopy can easily recognize finger-like villi (Figure 1) [16,17] .…”

Section: Capsule Endoscopymentioning

confidence: 99%

“…Capsule was more sensitive than conventional endoscopy in identifying endoscopic markers, but the difference observed did not achieve statistical significance. In the largest presented series, Rondonotti et al [19] reported on 43 consecutive patients with signs and/or symptoms suggestive of celiac disease and positive serological markers who underwent upper GI endoscopy and video capsule endoscopy. 87.5% of patients who had characteristic histological changes were diagnosed with celiac disease by capsule endoscopy.…”

Section: Capsule Endoscopymentioning

confidence: 99%

“…Preliminary reports suggest that capsule endoscopy could represent an attractive and non-invasive diagnostic tool in patients with suspected celiac disease [15][16][17][18][19] . It can also be used in patients with known celiac disease for monitoring small bowel healing; in patients with alarming symptoms despite a closely followed gluten-free diet and in long-term surveillance to detect malignancies [20] .…”

Section: Capsule Endoscopymentioning

confidence: 99%

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Capsule endoscopy in celiac disease

Spada¹,

Riccioni²,

Urgesi³

et al. 2008

WJG

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Video capsule endoscopy is an attractive and patientfriendly tool that provides high quality images of the small bowel. Obscure gastrointestinal bleeding is the primary and most evaluated indication to capsule endoscopy; however, indications are expanding and a small number of preliminary reports have been presented concerning the role of video capsule endoscopy in the diagnosis of celiac disease. The purpose of this review is to update the current knowledge and to hypothesize on future perspectives of the use of video capsule endoscopy in patients with celiac disease.

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Section: Capsule Endoscopysupporting

confidence: 82%

Section: Capsule Endoscopymentioning

confidence: 99%

Section: Capsule Endoscopymentioning

confidence: 99%

Section: Capsule Endoscopymentioning

confidence: 99%

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Capsule endoscopy in celiac disease

Spada¹,

Riccioni²,

Urgesi³

et al. 2008

WJG

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“…However, it must be stressed that CD mucosal lesions might be patchy [4], and that we had no way of measuring the extent of the lesions throughout the small bowel in our patients. The area of involved mucosa may be another major determinant of the clinical expression of CD and should be assessed by video capsule endoscopy studies [34].…”

Section: Discussionmentioning

confidence: 99%

Serology in adults with celiac disease: limited accuracy in patients with mild histological lesions

et al. 2011

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Celiac disease (CD) is a gluten-triggered enteropathy, presenting with insidious clinical patterns. It can occasionally be diagnosed in asymptomatic subjects. Our aim was to define the relationship among symptoms at diagnosis, serological markers [tissue transglutaminase antibodies (tTGA), anti-endomysium antibodies (EMA) anti-actin antibodies (AAA)] and degree of mucosal damage. A total of 68 consecutive adult patients with CD were enrolled. Intestinal biopsies were scored according to the Marsh classification modified by Oberhuber: I-II minimal lesions or absent villous atrophy; IIIA partial villous atrophy; IIIB-C total villous atrophy (TVA). HLA-typing was done for all patients. No association between clinical presentation and severity of mucosal damage was found. Presence of EMA or tTGA was significantly associated with more severe mucosal damage (P \ 0.001). Of 12 patients, 11 with AAA were also positive for TVA. The severity of mucosal damage is the main factor governing the detectability of serological markers of CD. The sensitivity of serological testing is questionable in patients with minimal lesions.

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