Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo

Goldstein, Jay L.; Eisen, Glenn M.; Lewis, Blair S.; Gralnek, Ian M.; Zlotnick, Steve; Fort, John G.

doi:10.1016/s1542-3565(04)00619-6

Cited by 630 publications

(443 citation statements)

References 33 publications

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“…A randomized, controlled trial revealed more mucosal breaks in a group of patients who used NSAIDs plus omeprazole compared with a group of patients who used COX-2 inhibitors. This study suggests relative protection of the COX-2 inhibitors compared with non-selective NSAIDs plus omeprazole against small bowel injury [43] . By contrast a non-randomized cohort study found similar rates and types of small bowel injury with long-term use of COX-2 selective agents versus NSAIDs [44] .…”

Section: Nsaids Related Intestinal Iniurymentioning

confidence: 72%

Gastrointestinal lesions associated with spondyloarthropathies

Orlando

Renna²,

Perricone³

et al. 2009

WJG

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Subclinical gut inflammation has been described in up to two-thirds of patients with spondyloarthropathies (S pA). Ar t hr i t is represents an extra-intestinal manifestation of several gastrointestinal diseases, including inflammatory bowel disease (IBD), Whipple's disease, Behcet's disease, celiac disease, intestinal bypass surgery, parasitic infections of the gut and pseudomembranous colitis. Moreover about twothirds of nonsteroidal anti-inflammatory drug users demonstrate intestinal inflammation. Arthritis may manifest as a peripheral or axial arthritis. The spondyloarthropathy family consists of the following entities: ankylosing spondylitis, undifferentiated s p o n d y l o a r t h r i t i s , r e a c t i ve a r t h r i t i s , p s o r i a t i c arthritis, spondyloarthritis associated with IBD, juvenile onset spondyloarthritis. This topic reviews the major gastrointestinal manifestations that can occur in patients with SpA and in nonsteroidal antiinflammatory drugs users.

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Section: Nsaids Related Intestinal Iniurymentioning

confidence: 72%

Gastrointestinal lesions associated with spondyloarthropathies

Orlando

Renna²,

Perricone³

et al. 2009

WJG

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“…Characteristic diaphragm-like strictures are said to be a result of chronic ulcers caused by NSAID, and in this regard it has been reported that 17% of patients with NSAID-induced small bowel ulcers can develop such stenoses [17]. On the other hand, the rate of non-excretion was zero in healthy asymptomatic volunteers [18].…”

Section: Discussionmentioning

confidence: 99%

Is the use of AGILE patency capsule prior to videocapsule endoscopy useful in all patients with spondyloarthritis?

Gheorghe

Zahiu

Voiosu

et al. 2017

Romanian Journal of Internal Medicine

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Background and aims. As already known, spondyloarthritis patients present a striking resemblance in intestinal inflammation with early Crohn's disease. Moreover, the frequent use of nonsteroidal anti-inflammatory drugs is an important part of their treatment. Both conditions could lead to intestinal stenoses. Therefore we proposed to investigate the usefulness of the patency capsule test in patients with spondyloarthritis.Material and methods. 64 consecutive patients (33 males; mean age 38 ± 11 years) that fulfilled the AMOR criteria for seronegative spondyloarthropathy (59.4% ankylosing spondylitis) lacking symptoms or signs of intestinal stenosis were enrolled and submitted to an AGILE™ capsule patency test followed by a video capsule endoscopy (PillCam SB2™), as part of a protocol investigating the presence of intestinal inflammatory lesions. After reviewing the VCE recordings, the Lewis score (of small bowel inflammatory involvement) was computed.Results. In only 5 patients (7.8%) of the study group, the luminal patency test was negative. However, there was no retention of the videocapsule in any of the patients. From the 59 patients with a positive patency test, 3 patients presented single small bowel stenoses (two with ulcerated overlying inflamed mucosa, one cicatricial), all being traversed by the videocapsule along the length of the recording. None of the patients with a negative test had bowel stenoses. There was no correlation between the patency test and the Lewis score, the C reactive protein value, diagnosis of inflammatory bowel disease, or the family history of spondyloarthritis, psoriasis or inflammatory bowel disease.Conclusion. The AGILE patency capsule does not seem to be a useful tool for all patients with spondyloarthritis prior to small bowel videocapsule endoscopy (ClinicalTrial.gov ID NCT 00768950).

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“…In patients with obstructive symptoms or one of the aforementioned risk factors, crosssectional imaging should be performed before VCE; however, absence of strictures on cross-sectional imaging does not preclude capsule retention [57] . The rate of capsule retention depends on the indication for performance of VCE [58] : 0% in healthy controls [59] , 1.4% in obscure gastrointestinal bleeding [60][61][62] , 1.48% in suspected CD [63][64][65] , 5%-13% in known CD [40,66] and 21% in suspected small bowel obstruction [67] . Slow transit of the capsule, with delayed excretion of the capsule is very common, seen in up to 20% of the cases [56] .…”

Section: Contraindications and Risksmentioning

confidence: 99%

Role of capsule endoscopy in inflammatory bowel disease

Leighton

Legnani

Seidman

2007

Inflammatory Bowel Diseases

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Videocapsule endoscopy (VCE) has revolutionized our ability to visualize the small bowel mucosa. This modality is a valuable tool for the diagnosis of obscure small bowel Crohn's disease (CD), and can also be used for monitoring of disease activity in patients with established small-bowel CD, detection of complications such as obscure bleeding and neoplasms, evaluation of response to anti-inflammatory treatment and postoperative recurrence following small bowel resection. VCE could also be an important tool in the management of patients with unclassified inflammatory bowel disease, potentially resulting in reclassification of these patients as having CD. Reports on postoperative monitoring and evaluation of patients with ileal pouch-anal anastomosis who have developed pouchitis have recenty been published. Monitoring of colonic inflammatory activity in patients with ulcerative colitis using the recently developed colonic capsule has also been reported. Capsule endoscopy is associated with an excellent safety profile. Although retention risk is increased in patients with small bowel CD, this risk can be significanty decreased by a routine utilization of a dissolvable patency capsule preceding the ingestion of the diagnostic capsule. This paper contains an overview of the current and future WJG 20 th Anniversary Special Issues (3): Inflammatory bowel disease TOPIC HIGHLIGHTclinical applications of capsule endoscopy in inflammatory bowel disease.

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Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo

Cited by 630 publications

References 33 publications

Gastrointestinal lesions associated with spondyloarthropathies

Gastrointestinal lesions associated with spondyloarthropathies

Is the use of AGILE patency capsule prior to videocapsule endoscopy useful in all patients with spondyloarthritis?

Role of capsule endoscopy in inflammatory bowel disease

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