Vichy volcanic mineralizing water has unique properties to strengthen the skin barrier and skin defenses against exposome aggressions

Abstract

Exposome aggressions are known to weaken certain skin functions, such as skin barrier and skin defense functions. Vichy volcanic mineralizing water (VVMW) percolates through volcanic and magmatic rocks in the Auvergne region in France to create a pure, highly mineralized water containing 15 minerals for a total mineral concentration of 5.2 g/L. Here, we provide an overview of the main results of in vitro and ex vivo studies (keratinocyte cultures, 3D reconstructed skin model, skin explants) and clinical studies to evaluate the effect of VVMW on key skin functions to help elucidate how it counteracts exposome aggressions on the skin. Properties to strengthen the skin barrier: VVMW stimulated the synthesis of tight junction proteins and keratinocyte differentiation markers in vitro. In clinical studies, VVMW accelerated cell turnover and improved skin hydration. Properties to strengthen skin antioxidant defense: VVMW stimulated the expression of antioxidant defense markers and had a higher stimulatory effect than a competitor thermal water on the expression of superoxide dismutase, catalase, and glutathione peroxidase in keratinocytes in vitro. In vivo, VVMW restored endogenous catalase activity after exposure to UVA radiation. Anti‐inflammatory action: VVMW reduced substance P‐induced inflammation ex vivo and lactic acid‐induced stinging in vivo. Topical application of VVMW in subjects with sensitive skin showed soothing and decongestant effects by reducing skin dryness and erythema. After sodium lauryl sulfate ‐induced skin barrier disruption, recovery from redness and erythema was faster following application of VVMW compared to a competitor water or untreated skin. These studies illustrate that VVMW has unique properties to repair and regenerate the skin barrier, as well as to strengthen antioxidant and immune defenses, which help protect the skin against exposome aggressions.

Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

“…Therefore, this study supports that adding a 1.5% HA‐containing cosmeceutical along with BoNTA improves signs of aging and skin quality compared to BoNTA alone and is well tolerated, even when used around eye contours. Indeed, while using sunscreen was required as key to a daily skin care routine, added benefits of an HA‐containing cosmeceutical were observed in this study which may be partly due to the effects of the HA‐filler serum's ingredients (notably Vitamin Cg, peptides, and volcanic mineralizing water) 12,13 . Additionally, this HA‐filler serum appears to prolong the duration of effect of BoNTA injections in reducing wrinkles.…”

“…A prospective, single‐blind, 24‐week RCT investigated the additional benefit of using a HA epidermic filler (Liftactiv HA epidermic filler [HA‐filler serum], Vichy, Paris, France) combined with BoNTA in the treatment of facial skin aging 12 . The HA‐filler serum, with 1.5% multimolecular weight HA, contains ingredients including Vitamin C glucoside (Cg), peptides, and volcanic mineralizing water that are intended to provide antioxidant and anti‐aging effects as well as strengthen the skin barrier 12–13 . Subjects were randomized to two groups: HA‐filler serum starting 24 h after the botulinum toxin injection followed by twice daily, or the control group, which received BoNTA.…”

“… 12 The HA‐filler serum, with 1.5% multimolecular weight HA, contains ingredients including Vitamin C glucoside (Cg), peptides, and volcanic mineralizing water that are intended to provide antioxidant and anti‐aging effects as well as strengthen the skin barrier. 12 , 13 Subjects were randomized to two groups: HA‐filler serum starting 24 h after the botulinum toxin injection followed by twice daily, or the control group, which received BoNTA. Both treatment groups received SPF 50+ sunscreen for use throughout the study.…”

A Randomized, Controlled Clinical Trial of a Dermocosmetic Containing Vichy Volcanic Mineralizing Water and Probiotic Fractions in Subjects with Rosacea Associated with Erythema and Sensitive Skin and Wearing Protective Masks

“…These minerals reinforce the natural defences of the skin by restoring the natural skin barrier, stimulating antioxidant activity and reducing inflammation, commonly observed in subjects with rosacea. 22 , 25 , 26 Probiotic fractions have been reported to play a potential role in the management of inflammatory skin diseases. 27 , 28 M89PF contains VfeV in a medium containing VVMW and cultured by a fermentation process to obtain an extract.…”

“…Recently, two investigations confirmed the benefit of M89PF in the management of acute stressed skin. 21 , 22 …”